Association of periodontitis with tinnitus: A population‐based cohort study in Taiwan

Su, Suzanne Ying‐Shan; Chien, Wu‐Chien; Chung, Chi‐Hsiang; Su, Wan‐Fu; Fu, Earl

doi:10.1111/jcpe.13670

Cited by 6 publications

(2 citation statements)

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“…The experimental group (periodontitis) was defined as “chronic periodontitis” patients with diagnostic code K053 (based on the International Classification of Diseases, ICD, 10th revision) assigned at least once in the period 2008–2010 (Su et al, 2022). The exclusion criteria were as follows: (1) patients diagnosed with periodontitis between 2011 and 2019; (2) those diagnosed with SFB or IFS before periodontitis; and (3) those under 20 years of age.…”

Section: Methodsmentioning

confidence: 99%

Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

Kim

Kang

Lee

et al. 2022

J Clinic Periodontology

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Aim The incidence of fungal sinusitis is increasing; however, its pathophysiology has not been investigated previously. We investigate the effect of periodontitis on the incidence of fungal sinusitis over a 12‐year follow‐up period using nationwide population‐based data. Materials and Methods The periodontitis group was randomly selected from the National Health Insurance Service database. The non‐periodontitis group was obtained by propensity score matching considering several variables. The primary end point was the diagnosis of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS). Results The periodontitis and non‐periodontitis groups included 12,442 and 12,442 individuals, respectively. The overall adjusted hazard ratio (aHR) for SFBs in the periodontitis group was 1.46 (p = .002). In subgroup analysis, the aHR for SFBs was 1.59 (p = 0.008) for those with underlying chronic kidney disease (CKD), 1.58 (p = .022) for those with underlying atopic dermatitis, 1.48 (p = .019) for those with chronic obstructive pulmonary disease (COPD), and 1.36 (p = .030) for those with diabetes mellitus (DM), but these values are applicable only when considering the relationship between periodontitis and SFB. The aHR for IFS in the periodontitis group was higher than in the non‐periodontitis group (2.80; p = .004). Conclusions The risk of SFBs and IFS increased after diagnosis of periodontitis. This trend is often more severe in patients with DM, COPD, or CKD, but this association with underlying diseases is applicable only when considering the association between periodontitis and fungal sinusitis.

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Section: Methodsmentioning

confidence: 99%

Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

Kim

Kang

Lee

et al. 2022

J Clinic Periodontology

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“…The periodontitis patients were then categorized into the mild and severe periodontitis groups as described previously [18][19][20][21] . The patients who had NHI order code for sub-gingival curettage/root planning (91006-91008C) or periodontal ap operation (91009B-91010B) were categorized into the severe periodontitis group, whereas those without these treatment codes were categorized into the mild periodontitis group 22 . The exclusion criteria for the study were as follows: the patients with periodontitis from January 1, 1998, to December 31, 1999; the patients with T2DM from 1998 to 1999 or before their rst visit during which periodontitis was diagnosed; the subjects aged <40 years; and those who had insu cient medical information or withdrawal from the NHI program throughout the 15-year study period (Fig.…”

Section: Study Design and Sampled Participantsmentioning

confidence: 99%

Diabetes and periodontitis: Bi-directional association in population-based 15-year retrospective cohorts

Chien

Chung

et al. 2022

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Two-way relationship between periodontitis and diabetes was advocated; however, bidirectional observation in general population is still inconclusive. Using the Taiwan Health Insurance Database (covering over 99% of the entire population),11,011 patients with severe periodontitis were recruited from 2000 to 2015.After matching by age, sex, and index date, 11,011 patients with mild periodontitis and 11,011 non-periodontitis controls were registered. The outcome of T2DM was traced. Conversely, the development of periodontitis was traced in 157,798 patients with T2DM, and 157,798 non-diabetic controls enrolled. The risks of T2DM significantly increased in groups with severe and mild periodontitis, with the adjusted hazard ratio (aHR) and 95% confidence interval (CI) being 1.94 (1.49–2.63, p < 0.01) and 1.72 (1.24–2.52, p < 0.01), respectively. Patients with severe periodontitis had a high risk of having diabetes compared to those with mild periodontitis [aHR, 1.17 (95% CI 1.04–1.26, p < 0.001)]. Conversely, the risk of periodontitis increased significantly in patients with T2DM [1.99 (1.42–2.48, p < 0.01)]. However, the high risk was not observed for the outcome of mild periodontitis [0.97 (0.38–1.57, p = 0.462)]. We, therefore, suggested the bi-direction is between diabetes and severe periodontitis, but not in mild type.

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Advances in acupuncture treatment for tinnitus

Yu,

Wu,

Sun

et al. 2024

American Journal of Otolaryngology

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Association of periodontitis with tinnitus: A population‐based cohort study in Taiwan

Abstract: Aim: Tinnitus, ringing in the ears, is speculated to be driven by inflammation. This study examined whether periodontitis is a risk factor for tinnitus using Taiwan's

Cited by 6 publications

References 52 publications

Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

Periodontitis is associated with the development of fungal sinusitis: A nationwide 12‐year follow‐up study

Diabetes and periodontitis: Bi-directional association in population-based 15-year retrospective cohorts

Advances in acupuncture treatment for tinnitus

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