Association of Photodynamic Therapy and Photobiomodulation As a Promising Treatment of Herpes Labialis: A Systematic Review

Khalil, Marwa M; Hamadah, Omar

doi:10.1089/photob.2021.0186

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…Topical methylene blue solutions have been used to treat different tegument pain syndromes, such as anal fissures and pain from genital herpes-simplex infections [13,14]. Multiple publications describe methylene blue as a long-term inhibition of peripheral axons, an antioxidant, and anti-inflammatory [15], hence its analgesic effect [16,17].…”

Section: Topical Effect Of Methylene Bluementioning

confidence: 99%

Methylene Blue for the Treatment of Radiation-Induced Oral Mucositis during Head and Neck Cancer Treatment: An Uncontrolled Cohort

Roldan

Rosenthal

Koyyalagunta

et al. 2023

Cancers

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Pain from radiation-therapy-induced oral mucositis during head-neck cancer treatment is aggravated by concurrent chemotherapy and commonly fails traditional treatments. To explore safe and sustainable alternatives, we investigated methylene blue oral rinse to reduce radiation-therapy-related oral mucositis pain. For this, we conducted a retrospective observational cohort study in a tertiary-care academic care cancer center including 85 patients with refractory oral mucositis pain during radiation therapy for head-neck cancer. Changes in pain (scale 0–10), oral function burden (scale 0–6) and requirement for percutaneous endoscopic gastrostomy tube placement were measured. Among 58 patients, 60% received radiation therapy alone and 40% received concurrent chemotherapy-radiation therapy. Methylene blue oral rinse (MBOR) significantly decreased oral mucositis pain for at least 6.2 h (median + SD 8 ± 1.68 before vs. 2 ± 2.20 after; p < 0.0001) and oral function burden (3.5 ± 1.33 before vs. 0 ± 0.86 after; p < 0.0001). Eleven patients (19%) had percutaneous endoscopic gastrostomy tubes placed before using methylene blue oral rinse; subsequently, four (36%) resumed oral alimentation after methylene blue oral rinse. Two patients (3%) required percutaneous endoscopic gastrostomy tubes despite methylene blue oral rinse. Minimal adverse events were reported (n = 9, 15%). Our study showed that methylene blue oral rinse was an effective and safe topical treatment for opioid-refractory oral pain from oral mucositis associated with radiation therapy for head-neck cancer.

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Section: Topical Effect Of Methylene Bluementioning

confidence: 99%

Methylene Blue for the Treatment of Radiation-Induced Oral Mucositis during Head and Neck Cancer Treatment: An Uncontrolled Cohort

Roldan

Rosenthal

Koyyalagunta

et al. 2023

Cancers

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“…For example, the most common photosensitizer for the treatment of Herpes simplex infection is methylene blue at concentrations between 0.1% and 1%, activated by lights with a wavelength of 660 nm. In another in vitro study, indocyanine green also showed good results when activated by wavelengths of 810 nm[ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of photodynamic therapy in the management of infectious oral diseases

Casu,

Orrù

2024

World J Exp Med

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Photodynamic therapy (PDT) can take place in the presence of three elements: Light with an appropriate wavelength; a photosensitizer; and the presence of oxygen. This type of treatment is very effective overall against bacterial, viral and mycotic cells. In the last 10 years many papers have been published on PDT with different types of photosensitizers (e.g. , methylene blue, toluidine blue, indocyanine green, curcumin-based photosensitizers), different wavelengths (e.g. , 460 nm, 630 nm, 660 nm, 810 nm) and various parameters (e.g. , power of the light, time of illumination, number of sessions). In the scientific literature all types of PDT seem very effective, even if it is difficult to find a standard protocol for each oral pathology. PDT could be an interesting way to treat some dangerous oral infections refractory to common pharmacological therapies, such as candidiasis from multidrug-resistant Candida spp .

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“…The photodynamic potential of MB in combination with visible light is successfully used in plasma decontamination with the THERAFLEX MB-Plasma (Macopharma) system [26]. Photodynamic therapy with MB shows positive effects in the treatment of plane warts [27] and herpes lesions [28,29].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Methylene Blue with Severe Acute Respiratory Syndrome Coronavirus 2 Envelope Revealed by Molecular Modeling

Kovalenko,

Kholina,

Fedorov

et al. 2023

IJMS

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Methylene blue has multiple antiviral properties against Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2). The ability of methylene blue to inhibit different stages of the virus life cycle, both in light-independent and photodynamic processes, is used in clinical practice. At the same time, the molecular aspects of the interactions of methylene blue with molecular components of coronaviruses are not fully understood. Here, we use Brownian dynamics to identify methylene blue binding sites on the SARS-CoV-2 envelope. The local lipid and protein composition of the coronavirus envelope plays a crucial role in the binding of this cationic dye. Viral structures targeted by methylene blue include the S and E proteins and negatively charged lipids. We compare the obtained results with known experimental data on the antiviral effects of methylene blue to elucidate the molecular basis of its activity against coronaviruses.

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Association of Photodynamic Therapy and Photobiomodulation As a Promising Treatment of Herpes Labialis: A Systematic Review

Cited by 10 publications

References 37 publications

Methylene Blue for the Treatment of Radiation-Induced Oral Mucositis during Head and Neck Cancer Treatment: An Uncontrolled Cohort

Methylene Blue for the Treatment of Radiation-Induced Oral Mucositis during Head and Neck Cancer Treatment: An Uncontrolled Cohort

Potential of photodynamic therapy in the management of infectious oral diseases

Interaction of Methylene Blue with Severe Acute Respiratory Syndrome Coronavirus 2 Envelope Revealed by Molecular Modeling

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