Association of phthalates with nasal patency and small airway dysfunction in first‐grade elementary school children

Kim, Mi Ae; Yon, Dong Keon; Jee, Hye Mi; Kim, Ju Hee; Park, Jisoo; Lee, Seung Won; Sung, Myongsoon; Sheen, Youn Ho; Han, Man Yong

doi:10.1111/all.14423

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…A study in first-grade elementary school children found correlations between urinary phthalate metabolite concentrations and nasal patency and lower small airway dysfunction. 40 The pathophysiological mechanisms by which air pollution mediates allergic disease are poorly understood; however, oxidative stress, enhanced sensitization to allergens, inflammatory and immunological responses, and epigenetic modifications have been suggested as possible mechanisms. [41][42][43] Exposure of human nasal epithelium cells to PM 2.5 was found to decrease loss of barrier function, as determined by measures of transepithelial resistance, permeability, decreased expression of tight junction proteins, and production of proinflammatory cytokines, such as thymic stromal lymphopoietin (TSLP).…”

Section: Many Of the Factors That Have Been Implicated In Allergic DImentioning

confidence: 99%

“…Children are more likely to have exposure to phthalates than adults through ingestion of dietary sources or inhalation of dust from phthalate containing products. A study in first‐grade elementary school children found correlations between urinary phthalate metabolite concentrations and nasal patency and lower small airway dysfunction 40 …”

Section: Factors Modulating Allergic Diseasementioning

confidence: 99%

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Advances and novel developments in environmental influences on the development of atopic diseases

Alkotob

Cannedy

Harter

et al. 2020

Allergy

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Both genes and the environment shape human health and disease. Although IgE-mediated allergic diseases (atopic diseases) have a genetic component and are more prevalent in individuals with a family history of allergic disease, the observed rapid increases in allergic diseases suggest that environmental factors are the predominant driving forces behind these increases rather than genetic alterations. 1,2 Common atopic diseases include atopic dermatitis, food allergy, allergic rhinitis, and allergic asthma. Human diets and lifestyle have undergone major alterations. The exposome, which is the sum total of all the exposures of an individual in a lifetime, has undergone major shifts in the last few decades, affecting human health and disease. A number of environmental factors have been implicated in the increased prevalence of allergic diseases. Predominant among them are increased exposure to pollutants and decreased exposure to microbes and parasitic infections. Air pollution has increased significantly in the last few decades. The hygiene hypothesis suggests that increased hygiene and lack of exposure to microbes and parasitic infections at an early age prevents the necessary stimulus to train the immune system to develop tolerogenic responses. Lifestyle factors,

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Section: Many Of the Factors That Have Been Implicated In Allergic DImentioning

confidence: 99%

Section: Factors Modulating Allergic Diseasementioning

confidence: 99%

Advances and novel developments in environmental influences on the development of atopic diseases

Alkotob

Cannedy

Harter

et al. 2020

Allergy

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show abstract

“…Epidemiological studies reported positive associations between indicators of phthalate exposure and risk of asthma, and allergic diseases 4,5 . Other studies reported that phthalates also adversely affect pulmonary functions 6,7 . Experimental studies demonstrated that exposure to phthalates increased the levels of T helper 2 (Th2) cells and cytokines, and also increased airway inflammation 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Other studies reported that phthalates also adversely affect pulmonary functions. 6,7 Experimental studies demonstrated that exposure to phthalates…”

mentioning

confidence: 99%

Association of phthalate exposure and airway dysfunction with mediation by serum periostin

Baek

Won

Kim

et al. 2021

Pediatric Allergy Immunology

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Previous studies reported that exposures to environmental pollutants are responsible for the increasing prevalence of allergic diseases. 1,2 Here, we focused on phthalates, a group of chemicals commonly used as plasticizers that commonly have higher concentrations in children than adults. 3 Phthalates can have adverse effects on the respiratory and immunological systems. Epidemiological studies reported positive associations between indicators of phthalate exposure and risk of asthma, and allergic diseases. 4,5 Other studies reported that phthalates also adversely affect pulmonary functions. 6,7 Experimental studies demonstrated that exposure to phthalates

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“…4,5 Other studies reported that phthalates also adversely affect pulmonary functions. 6,7 Experimental studies demonstrated that exposure to phthalates increased the levels of T helper 2 (Th2) cells and cytokines, and also increased airway inflammation. 8,9 Several clinical studies found an association between phthalate exposure and fractional exhaled nitric oxide (FeNO).…”

Section: Introductionmentioning

confidence: 99%

Association of phthalate exposure and airway dysfunction, with mediation by serum periostin

Baek

Won

Kim

et al. 2020

Preprint

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Association of phthalates with nasal patency and small airway dysfunction in first‐grade elementary school children

Cited by 9 publications

References 9 publications

Advances and novel developments in environmental influences on the development of atopic diseases

Advances and novel developments in environmental influences on the development of atopic diseases

Association of phthalate exposure and airway dysfunction with mediation by serum periostin

Association of phthalate exposure and airway dysfunction, with mediation by serum periostin

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