Association of physical activity and sedentary time with blood cell counts: National Health and Nutrition Survey 2003-2006

Willis, Erik A.; Shearer, Joseph J.; Matthews, Charles E.; Hofmann, Jonathan N.

doi:10.1371/journal.pone.0204277

Cited by 16 publications

(38 citation statements)

References 31 publications

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“…The association between genetically determined increased PA and decreased lymphocyte levels is partly in line with previous research which studied the association between PA and total leukocyte count [8]. In 4,857 individuals with a mean age of 43 ± 1 year and 43% females, participating in the National Health and Nutrition Examination Survey, the association between increased PA and a decreased leukocyte count has been observed, suggesting that active individuals might maintain a lower inflammatory state and might be less prone to future chronic disease development [8]. We did not assess the correlations between self-reported PA and circulating blood cells, and this study can therefore not be directly compared with these previous studies.…”

Section: Discussionsupporting

confidence: 87%

“…However, the exact mechanisms underlying the associations of PA the development of disease are incompletely understood. It has been suggested that systemic inflammation plays a pivotal role in the association between PA and CVD, possibly through changes in circulating (inflammatory) blood cells [8,9]. It is therefore important to investigate whether the effects of PA on CVD risk could be linked through changes in circulating blood cells.…”

Section: Introductionmentioning

confidence: 99%

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Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

Prins

Said

Vegte

et al. 2019

Genes

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Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemic inflammation, in which circulating blood cells play a pivotal role. In this study we investigated the relationship between genetically determined PA and circulating blood cells. We used 68 single nucleotide polymorphisms associated with objectively measured PA levels to perform a Mendelian randomization analysis on circulating blood cells in 222,645 participants of the UK Biobank. For inverse variance fixed effects Mendelian randomization analyses, p < 1.85 × 10−3 (Bonferroni-adjusted p-value of 0.05/27 tests) was considered statistically significant. Genetically determined increased PA was associated with decreased lymphocytes (β = –0.03, SE = 0.008, p = 1.35 × 10−3) and decreased eosinophils (β = –0.008, SE = 0.002, p = 1.36 × 10−3). Although further mechanistic studies are warranted, these findings suggest increased physical activity is associated with an improved inflammatory state with fewer lymphocytes and eosinophils.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

Prins

Said

Vegte

et al. 2019

Genes

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“…For example, a study by Willis et al concluded that higher levels of MVPA were associated with lower WBC counts among US adults from the National Health and Nutrition Survey 2003-2006. 16 Similarly, Prins et al 17 supported this hypothesis and suggested that increased genetically determined PA is associated with decreased lymphocyte and eosinophil levels. In contrast, investigations of sedentary behavior and WBC counts have produced conflicting results.…”

Section: Introductionmentioning

confidence: 93%

Cardiorespiratory fitness, physical activity, sedentary behavior, and circulating white blood cells in US youth

García-Hermoso

Ramírez‐Vélez

Alfonso-Rosa

et al. 2020

Scandinavian Med Sci Sports

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The white blood cell (WBC) count indicates the number of white blood cells (ie, neutrophils, lymphocytes, monocytes, basophils, and eosinophils) in a sample of blood. High or extremely low total WBC counts in circulation at resting conditions could be related to the presence of illness. White blood cells are made in the bone marrow and protect the body against infection and aid in the immune response. 1 Importantly, the WBC count is considered a clinical marker that reflects inflammatory processes related to cardiometabolic disorders involved in the development of cardiovascular diseases (CVD). 1 Existing research recognizes the critical role physical activity (PA) plays on the immune system of children 2 by inducing both a short-term pro-inflammatory effect and a long-term anti-inflammatory effect, a dual response that is mediated by the coordinated activation of numerous cytokines and chemokines. 3 Previous research has established that moderate-to-vigorous PA (MVPA) 4,5 and cardiorespiratory

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“…These authors also suggest that exercise may lower WBC count through its direct impact on bone marrow haematopoiesis [27]. Furthermore, various studies have shown that increased total WBC levels are related with lower physical activity, albeit most these reports focus on adult subjects [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

White Blood Cells in a Healthy Adolescent Population According to Social and Health Characteristics

Barroso

Ramos

Craveiro

et al. 2020

Preprint

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Background: The immune system constitutes a sensory system both for intrinsic and extrinsic factors. Among the extrinsic factors, social and environmental determinants of health may influence and shape the immune system from the childhood to adulthood. The aim of this study was to assess the total and differential white blood cells (WBC) according to social and environmental determinants of health in an adolescent population. Methods: As part of the population-based cohort Epidemiological Health Investigation of Teenagers in Porto (EPITeen), 1213 adolescents were evaluated at the age of 13. Total and differential WBC were evaluated through a venous blood sample. Sociodemographic, behaviour and clinical data were collected by self-administered questionnaires. Results: Total WBC levels were positively related to female gender, increased body mass index (BMI) and negatively related to private school enrollment, high parental education and practice of sports. The percentage of neutrophils was positively related to female gender, low parental education and lack of sports practice, while the percentage of eosinophils was positively related to chronic disease and medication, allergy, asthma and rhinitis. Monocytes proportion was negatively related to female gender, chronic disease and medication, allergy, asthma and increased BMI. Conclusions: The presence of disease was associated with an allergic response pattern, while the worse socioeconomic conditions and lack of sports activity were characterized by an inflammatory response pattern. Therefore, our results show that different exposures lead to distinct immune patterns of response that may last and shape the immune system.

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Association of physical activity and sedentary time with blood cell counts: National Health and Nutrition Survey 2003-2006

Cited by 16 publications

References 31 publications

Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

Cardiorespiratory fitness, physical activity, sedentary behavior, and circulating white blood cells in US youth

White Blood Cells in a Healthy Adolescent Population According to Social and Health Characteristics

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