Association of physical activity and IL-10 levels 20years after sulfur mustard exposure: Sardasht-Iran cohort study

Ghazanfari, Zeinab; Ghazanfari, Tooba; Kermani-Jalilvand, Arezou; Yaraee, Roya; Mahdavi, Mohammad Reza Vaez; Foroutan, Abbas; Araghizadeh, H; Faghihzadeh, Soghrat; Moaiedmohseni, Sakine; Soroush, Mohammad Reza; Naghizadeh, Mohammad Mehdi; Hassan, Zuhair Mohammad

doi:10.1016/j.intimp.2009.08.025

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…Regarding the anti inflammatory role of MCP-1 which is reported in various studies its higher expression may reflect the regulating mechanisms of immune system in order to control chronic inflammation in long term SM exposure. In support of this hypothesis our other findings showed a decrease in inflammatory cytokines [31] and an increase in anti inflammatory cytokine IL10 [32], indicating immune mechanisms for reestablishing of homeostasis. Further investigations are needed to elucidate the underlying mechanisms.…”

Section: Il-8/cxcl8supporting

confidence: 78%

Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Ghazanfari

Yaraee

Kariminia

et al. 2009

International Immunopharmacology

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Section: Il-8/cxcl8supporting

confidence: 78%

Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Ghazanfari

Yaraee

Kariminia

et al. 2009

International Immunopharmacology

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“…This increase may be contributed to other regulatory cytokines than inflammatory ones that are more important in chronic inflammation. In the other report we showed increased levels of IL-10 in the same SM exposed subjects [39]. IL-10 induces the expression of E-selectin on both human dermal microvascular endothelial cells and human umbilical vein endothelial cells, and that the levels of expression on HDMEC are comparable with that induced by IL-1β and tumor necrosis factor-α [40].…”

Section: Wbc-diffsupporting

confidence: 52%

Alterations in the serum levels of soluble L, P and E-selectin 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Yaraee

Ghazanfari

Faghihzadeh

et al. 2009

International Immunopharmacology

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“…and IL-8 [17,18]. and a significant increase in anti-inflammatory cytokines, namely MCP-1 and IL-10, in SM-exposed individuals as compared to those of the control group [19,20]. In our previous study, it was shown that salivary levels of sIgA and A1AT in SM-exposed victims, as compared to those of the unexposed control group, was higher but there was no significant increase in the salivary level of C5a in SM-exposed victims in comparison to that of the unexposed individuals [11].…”

Section: Discussionmentioning

confidence: 98%

Correlation of α1-Antitrypsin (A1AT), Complement Component C5a and Secretory Immunoglobulin A (sIgA) With Pulmonary Complications; 20 Years After Sulfur Mustard Exposure, Sardasht-Iran Cohort Study

et al. 2018

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Background: Little is known about pulmonary complications induced by Sulfur Mustard (SM), as a chemical warfare agent, especially considering its long term effects. The present study was carried out to investigate the association of α1-Antitrypsin (A1AT), Complement component C5a, and Secretory Immunoglobulin A (sIgA) with long-term pulmonary complications on SM-exposed individuals, 20 years after the exposure. Materials and Methods: Sardasht-Iran Cohort Study (SICS) is a historical cohort study on 372 SM-exposed individuals and 128 age-matched unexposed participants. The clinical evaluations and Spirometry were performed on all the participants according to American Thoracic Society Criteria. Also, we assessed the salivary levels of A1AT, C5a, and sIgA using ELISA assay. Results: The results indicated significant associations between salivary levels of A1AT, C5a, and sIgA with chronic cough in the exposed victims. Also, there were associations between C5a and sIgA with dyspnea in SM-exposed victims with chronic cough compared with those in the exposed victims without chronic cough. The salivary levels of C5a significantly decreased in severe pulmonary involvement. Moreover, a significant relationship was observed between the salivary levels of C5a and pulmonary function testes. Conclusion: According to the findings, the salivary level of C5a might reflect the severity of pulmonary involvements following SM exposure. A1AT, as a protective agent, has correlations with cough and dyspnea. Although no strong correlation was found between the salivary levels of these factors with persistence of pulmonary complications, they can be effective in the development and progression of pathological changes in the lungs of the SM-exposed victims.

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Association of physical activity and IL-10 levels 20years after sulfur mustard exposure: Sardasht-Iran cohort study

Cited by 9 publications

References 30 publications

Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Alterations in the serum levels of chemokines 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Alterations in the serum levels of soluble L, P and E-selectin 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study

Correlation of α1-Antitrypsin (A1AT), Complement Component C5a and Secretory Immunoglobulin A (sIgA) With Pulmonary Complications; 20 Years After Sulfur Mustard Exposure, Sardasht-Iran Cohort Study

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