Association of physical activity and nutrition with telomere length, a marker of cellular aging: A comprehensive review

Güneşliol, Bartu Eren; Karaca, Erkin; Ağagündüz, Duygu; Acar, Zeynep Alanur

doi:10.1080/10408398.2021.1952402

Cited by 13 publications

(5 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comprehensive review of several human and animal model studies suggests that exercise can alleviate telomere shortening. Individuals engaging in physical exercise have longer telomeres compared to non-participants ( 53 ). Even daily leisure activities contribute to reducing telomere attrition ( 54 ).…”

Section: Resultsmentioning

confidence: 99%

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Du,

Fan,

Kong

2024

Front. Med.

View full text Add to dashboard Cite

BackgroundKnee osteoarthritis (KOA) is a disease that significantly affects the quality of life of patients, with a complex pathophysiology that includes degeneration of cartilage and subchondral bone, synovitis, and associations with mechanical load, inflammation, metabolic factors, hormonal changes, and aging.ObjectiveThis article aims to comprehensively review the biological mechanisms and clinical effects of general exercise training and traditional Chinese exercises (such as Tai Chi and Qigong) on the treatment of KOA, providing references for the development of clinical exercise prescriptions.MethodsA systematic search of databases including PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure (CNKI) was conducted, reviewing studies including randomized controlled trials (RCTs), observational studies, systematic reviews, and meta-analyses. Keywords included “knee osteoarthritis,” “exercise therapy,” “physical activity,” and “traditional Chinese exercise.”Results and conclusionGeneral exercise training positively affects KOA by mechanisms such as promoting blood circulation, improving the metabolism of inflammatory factors, enhancing the expression of anti-inflammatory cytokines, and reducing cartilage cell aging. Traditional Chinese exercises, like Tai Chi and Qigong, benefit the improvement of KOA symptoms and tissue repair by regulating immune function and alleviating joint inflammation. Clinical studies have shown that both types of exercise can improve physical function, quality of life, and pain relief in patients with KOA. Both general exercise training and traditional Chinese exercises are non-pharmacological treatment options for KOA that can effectively improve patients’ physiological function and quality of life. Future research should further explore the long-term effects and biological mechanisms of these exercise interventions and develop personalized exercise programs based on the specific needs of patients.

show abstract

Section: Resultsmentioning

confidence: 99%

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Du,

Fan,

Kong

2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…In this brief report, we found a significant shortening of telomere length in the liver of patients with AH and AC. Telomere length homeostasis is important for cell survival as short telomeres initiate DNA damage, induce senescence and apoptosis,8 a possible mechanism underlying alcohol-induced liver injury. An increase in the expression of genes regulating telomere binding protein is likely in response to telomere shortening, especially in patients with AC; a previous study has shown that TRF1 is involved in the negative feedback mechanism to stabilize the length of telomeres 23.…”

Section: Discussionmentioning

confidence: 99%

“…7 Dysregulation in this process may lead to telomere shortening which has downstream effects, causing cellular senescence, chromosomal instability, and impaired cellular homeostasis. 8 Telomere shortening has been reported in patients with chronic hepatitis, notably hepatitis C, non-alcoholic fatty liver disease, cirrhosis, and hepatocellular carcinoma. [9][10][11] The telomere length has not been systemically studied in patients with alcohol-associated liver disease (ALD), the disease with a spectrum of histopathological changes from steatosis, alcohol-associated hepatitis (AH), and alcohol-associated cirrhosis (AC).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Telomere Length in Patients with Alcohol-Associated Liver Disease: A Brief Report

Huda

Kusumanchi

Perez

et al. 2022

Journal of Investigative Medicine

View full text Add to dashboard Cite

The intact telomere structure is essential for the prevention of the chromosome end-to-end fusions and maintaining genomic integrity. The maintenance of telomere length is critical for cellular homeostasis. The shortening of telomeres has been reported in patients with chronic liver diseases. The telomere length has not been systemically studied in patients with alcohol-associated liver disease (ALD) at different stages, such as alcoholic hepatitis and alcoholic cirrhosis. In this brief report, we observed evidence of telomere shortening without changes in the telomerase activity in the liver of patients with alcoholic hepatitis and alcoholic cirrhosis when compared with controls. The alterations in the genes associated with telomere binding proteins were only observed in patients with alcoholic cirrhosis. Future studies are required to determine the mechanism of how alcohol affects the length of the telomere and if the shortening impacts the disease progression in ALD.

show abstract

“…A probable association exists between the length of telomeres and lifestyle factors, such as levels of physical activity and dietary patterns. The implementation of regular physical activity and a healthy diet have been postulated to potentially mitigate the process of telomere shortening, hence exhibiting potential anti-aging properties (Güneşliol et al, 2023).…”

Section: Nutrition and Telomere Lengthmentioning

confidence: 99%

The Relationship Between Vitamin B12 and Telomere Length: A Systematic Review

Yıldırım,

Ekici

2023

Turkish JAF Sci.Tech.

View full text Add to dashboard Cite

Telomeres are natural nucleoprotein structures that cover the ends of chromosomes. The phenomenon of telomere shortening, which plays a crucial role in maintaining the stability of the genome, occurs gradually over time when cells undergo division due to the end replication issue. Multiple studies have demonstrated a correlation between telomere shortening and a range of illnesses, including diabetes, dyslipidemia, cardiovascular disease, cancer, and mortality. Diet and lifestyle can affect telomere length. There exists a beneficial association between telomere length and the Mediterranean diet, particularly with regards to the consumption of dietary fiber derived from whole grains and vegetables. Micronutrients such as vitamins and trace elements also play a role in cell metabolism. Some micronutrients, such as vitamin D, folate, and vitamin B12, are associated with telomere biology and cellular aging. Vitamin B12 is essential for DNA synthesis and epigenetic methylation processes. The present systematic review examines the results from clinical trials conducted in humans evaluating the role of vitamin B12 on telomere length. Cellular senescence is a state characterized by inflammation, altered cellular metabolism, genomic instability, and telomere dysfunction, which can be induced by changes in methylation patterns and oxidative stress. Vitamin B12 maintains antioxidative defense. Through these pathways, sufficient amounts of vitamin B12 may potentially play a role in the restoration of DNA damage. Most of the evidence is based on very few randomized clinical trials. Therefore, more extensive prospective cohort studies and better-designed randomized clinical trials are required to validate the correlations outlined in this review.

show abstract

Association of physical activity and nutrition with telomere length, a marker of cellular aging: A comprehensive review

Cited by 13 publications

References 122 publications

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Telomere Length in Patients with Alcohol-Associated Liver Disease: A Brief Report

The Relationship Between Vitamin B12 and Telomere Length: A Systematic Review

Contact Info

Product

Resources

About