Association of placental perfusion, as assessed by magnetic resonance imaging and uterine artery Doppler ultrasound, and its relationship to pregnancy outcome

Derwig, Iris; Lythgoe, David J.; Barker, Gareth J.; Poon, Liona C.; Gowland, Penny; Yeung, Roseanne O.; Zelaya, Fernando; Nicolaides, Kypros H.

doi:10.1016/j.placenta.2013.07.006

Cited by 94 publications

(121 citation statements)

References 29 publications

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“…To our knowledge, only one study, that of Derwig et al ., has investigated possible correlations between placental perfusion fraction and Doppler blood flow in the uterine artery and infant birth weight17. Their results are in accordance with ours, with correlations between the placental perfusion fraction and infant birth‐weight percentile ( R = 0.40) and the mean uterine artery PI ( R = 0.48).…”

Section: Discussionsupporting

confidence: 83%

“…However, MRI can also provide physiological information such as the perfusion fraction, an in‐vivo estimate of the volume fraction of perfused tissue13, 14, 15, the examination for which can be performed within minutes. Previous studies have investigated the placental perfusion fraction in vivo 16, 17, 18, 19. One study showed that a small placental perfusion fraction in the second trimester was strongly associated with delivering a small‐for‐gestational age (SGA) neonate17.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have investigated the placental perfusion fraction in vivo 16, 17, 18, 19. One study showed that a small placental perfusion fraction in the second trimester was strongly associated with delivering a small‐for‐gestational age (SGA) neonate17. The aim of this study was to investigate the placental perfusion fraction as a potential marker for placental function.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Sohlberg

Mulic‐Lutvica

Olovsson

et al. 2015

Ultrasound in Obstet & Gyne

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ObjectiveTo evaluate in‐vivo placental perfusion fraction, estimated by magnetic resonance imaging (MRI), as a marker of placental function.MethodsA study population of 35 pregnant women, of whom 13 had pre‐eclampsia (PE), were examined at 22–40 weeks' gestation. Within a 24‐h period, each woman underwent an MRI diffusion‐weighted sequence (from which we calculated the placental perfusion fraction), venous blood sampling and an ultrasound examination including estimation of fetal weight, amniotic fluid index and Doppler velocity measurements. The perfusion fractions in pregnancies with and without fetal growth restriction were compared and correlations between the perfusion fraction and ultrasound estimates and plasma markers were estimated using linear regression. The associations between the placental perfusion fraction and ultrasound estimates were modified by the presence of PE (P < 0.05) and therefore we included an interaction term between PE and covariates in the models.ResultsThe median placental perfusion fractions in pregnancies with and without fetal growth restriction were 21% and 32%, respectively (P = 0.005). The correlations between placental perfusion fraction and ultrasound estimates and plasma markers were highly significant (P = 0.002 and P = 0.0001, respectively). The highest coefficient of determination (R 2 = 0.56) for placental perfusion fraction was found for a model that included pulsatility index in the ductus venosus, plasma level of soluble fms‐like tyrosine kinase‐1, estimated fetal weight and presence of PE.ConclusionThe placental perfusion fraction has the potential to contribute to the clinical assessment of cases with placental insufficiency. © 2015 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Sohlberg

Mulic‐Lutvica

Olovsson

et al. 2015

Ultrasound in Obstet & Gyne

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“…68 36,38 The perfusion map showed more areas of low perfusion in relation to a decrease in placental perfusion in IUGR pregnancies (923 vs 2359 arbitrary units; P ¼ .003) 38 ; a correlation with the uterine artery pulsatility index was established later (Table 2). 77 Limitations Although ASL MRI can yield a quantitative estimate of placental perfusion without using an exogenous contrast agent, only a few studies have been published since the seminal publications in 1998. 36,38 The limitations of this technique are a poor signal-to-noise ratio (SNR) with most methods, owing to small measurable differences between tagged and untagged images and an important sensitivity to motion, transit delay, and resonance offset artifacts.…”

Section: Ajogorgmentioning

confidence: 99%

“…99,100 Normal f values range from 26e36% for the whole placenta and decrease with gestational age. 34,45,77,101 The f value also varies, depending on the location within the placenta: it is higher in the basal plate than in the chorionic plate. 34,45,77,101 In IUGR placentas, ADC and f appear significantly decreased compared with normal pregnancies.…”

Section: Basic Conceptsmentioning

confidence: 99%

Functional imaging of the human placenta with magnetic resonance

Siauve

Chalouhi

Deloison

et al. 2015

American Journal of Obstetrics and Gynecology

117

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Placental location and obstetrical‐neonatal outcomes: A retrospective study

Doctory

Romano

Navon

et al. 2022

Intl J Gynecology & Obste

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Objective To explore the potential association of lateral placentation with pregnancy outcome. Methods The database of a tertiary medical center was searched for women who gave birth to a singleton neonate from 2012 to 2020 for whom placental location was documented during antepartum sonographic examination. Clinical data were compared between patients with a central (anterior/posterior/fundal) or lateral placenta using standard statistics. The primary outcome measure was neonatal birthweight, and secondary outcome measures were pregnancy complications and mode of delivery. Results The cohort included 12 306 women: 11 608 (94%) with a central placenta and 698 (5.6%) with a lateral placenta. The lateral placenta group had higher rates (P < 0.05) of prior and current cesarean delivery, assisted delivery, and preterm birth. On multivariate regression analyses, placental location (adjusted odds ratio [aOR], 1.36; 95% confidence interval [CI], 1.11–1.66) and maternal age (aOR, 1.02; 95% CI, 1.01–1.03) were associated with risk of preterm birth. Lateral placenta (aOR, 1.22; 95% CI, 1.02–1.47), maternal age (aOR, 1.07; 95% CI, 1.06–1.08), parity (aOR, 0.32; 95% CI, 0.28–0.35), and prior cesarean delivery (aOR, 12.00; 95% CI, 10.60–13.60) were associated with risk of current cesarean delivery. Conclusion The findings suggest that lateral placentation may pose a risk of preterm birth and cesarean delivery compared with central placentation.

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Association of placental perfusion, as assessed by magnetic resonance imaging and uterine artery Doppler ultrasound, and its relationship to pregnancy outcome

Cited by 94 publications

References 29 publications

Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

Functional imaging of the human placenta with magnetic resonance

Placental location and obstetrical‐neonatal outcomes: A retrospective study

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