1994
DOI: 10.1006/bbrc.1994.2213
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Association of Plakoglobin with APC, a Tumor-Suppressor Gene Product, and Its Regulation by Tyrosine Phosphorylation

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Cited by 75 publications
(41 citation statements)
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“…Thus, it is logical that this cell -cell zipper would disappear concomitant with increased cellular invasion (Shibata et al, 1994). This disappearance of E-cadherin and/or any of the major adhesion components affiliated with it is noted in most advanced carcinoma cells (Takeichi, 1977;Hazan and Norton, 1998;Takeda et al, 1999).…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…Thus, it is logical that this cell -cell zipper would disappear concomitant with increased cellular invasion (Shibata et al, 1994). This disappearance of E-cadherin and/or any of the major adhesion components affiliated with it is noted in most advanced carcinoma cells (Takeichi, 1977;Hazan and Norton, 1998;Takeda et al, 1999).…”
Section: Discussionmentioning
confidence: 98%
“…These molecules not only play structural roles but also alter cell responses and phenotypes. b-Catenin is also found to immunoprecipitate with the APC tumour suppressor protein (Su et al, 1993;Hulsken et al, 1994;Shibata et al, 1994), and has been recently identified as an oncogene (Kim et al, 2002;Minamoto et al, 2002;Kielhorn et al, 2003;Schneider et al, 2003). It is also central to cell signalling, as upon dissociation from E-cadherin, it transits to the nucleus to alter transcriptional profiles (Mason et al, 2002;van de Wetering et al, 2002).…”
mentioning
confidence: 99%
“…These membranes were incubated with radiolabeled fusion proteins in HBB buffer (20 mM Hepes, pH 7.5, 5.5 mM MgCl 2 , 1 mM KCl, 5 mM dithiothreitol, 10 mM glutathione) and washed with TPBS (0.2% Triton X-100 in phosphate-buffered saline) as described previously (21). After three rounds of screening, positive phages were isolated and digested with EcoRI, and the inserts were subcloned into pBSKII-SK (Stratagene) vector for sequence analysis.…”
Section: Methodsmentioning
confidence: 99%
“…All the PCR products were sequenced. Glutathione-S-transferase (GST) fusion proteins were expressed in JM109, as described by Shibata et al (15).…”
Section: Generation Of Recombinant Proteins and In Vitro Bindingmentioning
confidence: 99%