Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation

Abstract

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) is one of the adipokines associated with obesity, diabetes, and coronary heart disease. The association between plasma CTRP3 levels and AF is uncertain. The aim of this study was to investigate whether plasma CTRP3 concentrations were correlated with AF. Our study included 75 AF patients who underwent catheter ablation at our hospital and 47 sinus rhythm patients to determine the difference in plasma CTRP3 concentrations. Blood samples before the ablation were collected, and ELISA was used to measure the concentrations of CTRP3. Plasma CTRP3 concentrations were significantly lower in AF patients compared with control group ( 366.9 ± 105.2 ng / ml vs. 429.1 ± 100.1 ng / ml , p = 0.002 ). In subgroup studies, patients with persistent AF had lower plasma CTRP3 concentrations than those with paroxysmal AF ( 328.3 ± 83.3 ng / ml vs. 380.0 ± 109.2 ng / ml , p = 0.037 ). The concentrations of plasma CTRP3 in the recurrence group after radiofrequency catheter ablation of AF were lower than those in the nonrecurrence group ( 337.9 ± 77.3 ng / ml vs. 386.6 ± 108.1 ng / ml , p = 0.045 ). Multivariate regression analysis revealed the independent correlation between plasma CTRP3 level and AF. Plasma CTRP3 concentrations were correlated with the presence of AF and AF recurrence.

ADHD‐associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient‐derived cell lines

“…4.1 | Immunological/inflammatory genes C1QTNF3 (C1q And TNF Related 3) plays a role in cytokine production regulation and the coded protein is counted as a adipokine and might be involved in obesity, diabetes mellitus and coronary heart disease (Chen et al, 2020). Mutations in the C1QTNF3 gene have been shown…”

“…C1QTNF3 (C1q And TNF Related 3) plays a role in cytokine production regulation and the coded protein is counted as a adipokine and might be involved in obesity, diabetes mellitus and coronary heart disease (Chen et al, 2020). Mutations in the C1QTNF3 gene have been shown previously in patients with familiar schizophrenia (Bespalova et al, 2010) hinting at a role in mental disorders.…”

CTRP-3 em Pacientes com Doença Arterial Coronariana Estável e Fibrilação Atrial Paroxística: Um Novo Biomarcador Potencial nas Doenças Cardiovasculares

“…Multivariate regression analysis revealed the independent correlation between plasma CTRP-3 level and AF. 11 In the present issue, Yildirim et al 12 studied 252 patients with CAD and 50 healthy controls, who were divided into DOI: https://doi.org/10.36660/abc.20210940 groups with and without CAD and CAD patients with and without paroxysmal AF. Serum CTRP-3 levels were significantly lower in patients with CAD than in the control group.…”

“…10 In the scenario of atrial fibrillation (AF), no study has reported whether CTRP-3 may play a role in AF and concomitant atrial remodeling. Chen et al 11 studied 75 AF patients who underwent catheter ablation and 47 sinus rhythm patients and found that plasma CTRP-3 concentrations were significantly lower in AF patients compared with control group. In subgroup studies, patients with persistent AF had lower plasma CTRP-3 concentrations than those with paroxysmal AF.…”

“…12 CTRP-3 is an independent factor of AF, and to some extent, it is related to the prognosis of patients with AF after radiofrequency ablation. 11 The CTRP family plays an important role in all stages of CAD by regulating immuno-inflammation, glucose and lipid metabolism, and vascular endothelial function. CTRP-1 represents as pro-inflammatory and pro-atherosclerotic markers by contributing toward the secretion of inflammatory cytokines and adhesion molecules and promoting the formation of foam cells from macrophages.…”