Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients

Increased Phospholipid Transfer Protein Activity Associated with the Impaired Cellular Cholesterol Efflux in Type 2 Diabetic Subjects with Coronary Artery Disease

“…We have shown that cholesteryl ester transfer protein (CETP) activity was increased in both D+C-and D+C+ patients as compared to controls (Chaaba et al 2005b), but, no association of CETP with cellular cholesterol efflux level nor with PLTP activity was revealed, in keeping with previous data (Speijer et al 1991;Francone et al 1996;Syvänne et al 1996).…”

Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus

“…The relationship between the TaqIB genotype and the risk of CAD in diabetes has been investigated in some population-based studies, albeit without consistent results [26][27][28]. Two previous studies [26,27] revealed CETP TaqIB gene polymorphism to be associated with macrovascular complications of diabetes.…”

“…Two previous studies [26,27] revealed CETP TaqIB gene polymorphism to be associated with macrovascular complications of diabetes. However, Chaaba et al [28] reported that there was no association between CETP TaqIB gene polymorphism and CAD in type 2 diabetes mellitus. Recently, a meta-analysis study [29] reported that the CETP TaqIB variant was associated with the risk of CAD, and this association was substantially attenuated on adjustment for HDL-C levels.…”

“…Recently, Chaaba et al [28] found that CETP TaqIB polymorphism was associated with CAD only in men with type 2 diabetes mellitus. In our study, diabetic patients with the B1B1 genotype were found to be at risk for CAD, provided they were female.…”

Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes

“…It is associated with dyslipidemia and high incidence of cardiovascular disease and complications. 13 Previous studies about cholesteryl ester transfer protein and ApoA-V polymorphism effect on lipid parameters and CAD have been conducted in Tunisian type 2 diabetic patients, 14,15 with no data on ApoE polymorphism. Only one study interested in ApoE polymorphism was conducted in healthy Tunisian subjects.…”