Association of plasma concentrations of salicylic acid and high on ASA platelet reactivity in type 2 diabetes patients

Postuła, Marek; Janicki, Piotr K.; Rosiak, Marek; Przybyłkowski, Adam; Kapłon‐Cieślicka, Agnieszka; Grygorowicz, Tomasz; Trzepla, Ewa; Filipiak‬, Krzysztof J.; Członkowski, Andrzej; Opolski, Grzegorz

doi:10.5603/cj.2013.0030

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…While ASA concentrations are more important for antiplatelet effects, in clinical studies SA levels are often measured because of the rapid breakdown of ASA to SA. However, SA levels have been shown to correlate with platelet function assays making it a useful surrogate measure [ 12 ]. In this study, ASA concentrations over 1,000 ng/mL were achieved within 5 minutes with the soluble formulation in both the fasting and fed states, however, this level was not achieved with the chewed tablet until 7 minutes in the fasting state, and was further delayed (10 minutes) in the fed state.…”

Section: Discussionmentioning

confidence: 99%

Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet

Atar¹,

Sarkar²,

Kolev³

et al. 2022

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Objectives: The primary objective of this study was to assess the pharmacokinetic profiles of acetylsalicylic acid (ASA) and salicylic acid (SA) after administration of two different formulations of aspirin under fasting and fed conditions. Materials and methods: The study was a randomized, open-label, parallel-group, 2-arm crossover study conducted at a single center. Healthy subjects were randomized to receive 300 mg of aspirin in either a 15-mL oral solution (pre-packaged vial containing powder and solvent that are combined at the time of administration) or a single solid tablet to be chewed and swallowed with 150 mL of water. Treatment visits were separated by a 10-day wash-out period. Results: At 3 minutes, ASA concentrations for the oral solution fed state and fasting state arms exceeded those for the chewed tablet (fed 299 vs. 139 ng/mL; fasting 356 vs. 204 ng/mL). Compared to the chewed tablet, the mean plasma ASA concentration was 74% greater with the oral solution under fasting conditions, and 115% greater under fed conditions. Similarly, at 3 minutes, the mean SA plasma concentration with the oral solution under fed and fasting conditions exceeded those for the chewed tablet (fed 310 vs. 160 ng/mL; fasting 330 vs. 185 ng/mL). Under fasting conditions, the mean plasma ASA AUC 0-last , with the oral solutions was 168,076.8 min.ng/mL compared to 163,726.3 min.ng/mL with the chewed tablet. Under fed conditions, the mean plasma ASA AUC 0-last , with the oral solutions was 179,116.7 min.ng/mL compared to 164,704.3 min.ng/mL with the chewed tablet. Conclusion: This phase 1 study showed that use of an aspirin oral solution provided more rapid exposure to higher plasma concentration levels of ASA and SA than chewing a solid tablet.

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Section: Discussionmentioning

confidence: 99%

Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet

Atar¹,

Sarkar²,

Kolev³

et al. 2022

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“…Different letters given in the upper index indicate the occurrence of statistical differences in the values of a given parameter between the three groups (Kruskal-Wallis ANOVA, p < 0.05); CRP -C-reactive protein; GFR -glomerular filtration rate; HDL-C -high density lipoprotein cholesterol; LDL-C -low density lipoprotein cholesterol Beata Krasińska et al, The effect of ASA dosed at bedtime on the anti-aggregation effect It should be remembered that physiologically, at all the times, new and uninhibited plates are released into the blood, which constitute about 10% of the total number. The release of new platelets may be greater in people with vascular disease [34][35][36]. It has been shown that in up to 25% of patients, inhibition of platelets by ASA decreases gradually within 24 h after its administration [18,37].…”

Section: Discussionmentioning

confidence: 99%

The effect of acetylsalicylic acid dosed at bedtime on the anti-aggregation effect in patients with coronary heart disease and arterial hypertension: A randomized, controlled trial

et al. 2020

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Background: Acetylsalicylic acid (ASA) is one of the basic drugs used in the secondary prevention of coronary artery disease (CAD), and in most cases it is taken in the morning in one daily dose. It is suggested that the morning peak of platelet aggregation is responsible for the occurrence of myocardial infarctions and strokes. Hence, the aim of the study was to observe the effect of ASA (morning vs. evening) dosing on the anti-aggregative effect of platelets in patients with CAD and arterial hypertension (AH). Methods: The study involved 175 patients with CAD and AH. Patients were randomly assigned to one of two study groups, taking ASA in the morning or in the evening. The patients had two visits, one baseline and another after 3 months from changing the time of ASA dosage. The platelet aggregation was determined using the VerifyNow analyzer. Results: In the ASA evening group, a significant reduction in platelet aggregation was obtained. In the ASA morning group, a significant difference in response to ASA was observed, depending on sex. In men, the reactivity of platelets decreased, but in women it increased. Conclusions: In the group of patients with CAD and AH, bedtime ASA dosing is associated with a significant reduction in platelet aggregation. The response to ASA may differ between sexes. The benefit gained by changing the drug administration from the morning to the evening is greater in women.

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“…Cao et al (2012) reported that salicylic acid pharmacokinetic study in diabetic rats achieved lower blood concentrations of salicylic acid than normal rats with a higher apparent clearance (CL/F) possibly due to incomplete (47%) bioavailability. Salicylic acid pharmacokinetic mechanisms might contribute to lower plasma salicylic acid levels, and subsequently incomplete inhibition of thromboxane A 2 synthesis as measured with S-TxB 2 concentrations and increased platelet reactivity in DM patients (Postula et al, 2013).…”

Section: Salicylic Acidmentioning

confidence: 99%

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

2015

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Diabetes mellitus (DM) has become a major public health threat across the globe. Current antidiabetic therapies are based on synthetic drugs that very often have side effects. It has been widely acknowledged that diet plays an important role in the management of diabetes. Phenolic acids are widely found in daily foods such as fruits, vegetables, cereals, legumes, and wine and they provide biological, medicinal, and health properties. Simple phenolic acids have been shown to increase glucose uptake and glycogen synthesis, improve glucose and lipid profiles of certain diseases (obesity, cardiovascular diseases, DM, and its complication). The current review is an attempt to list out the antidiabetic effects of simple phenolic acids from medicinal plants and botanical foods.

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Association of plasma concentrations of salicylic acid and high on ASA platelet reactivity in type 2 diabetes patients

Cited by 8 publications

References 27 publications

Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet

Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet

The effect of acetylsalicylic acid dosed at bedtime on the anti-aggregation effect in patients with coronary heart disease and arterial hypertension: A randomized, controlled trial

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

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