Association of Plasma Dehydroepiandrosterone-Sulfate Levels with Endothelial Function in Postmenopausal Women with Coronary Risk Factors

Akishita, Masahiro; Hashimoto, Masayoshi; Ohike, Yumiko; Ogawa, Sumito; Iijima, Katsuya; Eto, Masato; Ouchi, Yasuyoshi

doi:10.1291/hypres.31.69

Cited by 24 publications

(19 citation statements)

References 36 publications

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“…It has been reported that several sex hormones (i.e., testosterone, estradiol, and dehydroepiandrosterone; DHEA) have cardio protective effects and some of them have been found a significant association with vascular function [11,12,21,22,23]. In the previous study, androgen suppressive therapy was found to increases the central SBP pressure in male patients with prostate cancer [24].…”

Section: Central Blood Pressure and Brachial Blood Pressure Measurementmentioning

confidence: 96%

Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

et al. 2015

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Section: Central Blood Pressure and Brachial Blood Pressure Measurementmentioning

confidence: 96%

Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

et al. 2015

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“…Akishita et al. [14] demonstrated that plasma DHEA‐S levels were significantly related to %FMD independent of age, body mass index, blood pressure, dyslipidemia diabetes, or smoking in postmenopausal women (N = 115) with coronary risk factors. Williams et al.…”

Section: Dhea Modulates Endothelial Functionmentioning

confidence: 99%

Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME)

Traish

Kang

Saad

et al. 2011

The Journal of Sexual Medicine

205

124

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Introduction The circulation of large amounts of dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEA-S) suggests a physiological role in human physiology. In the central nervous system, DHEA is considered a neurosteroid with a wide range of functions. Aim The goal of this review is to discuss metabolism, biochemical, and physiological mechanism of DHEA action and the potential role of DHEA in aging and in ameliorating a host of pathological conditions, associated with aging. Methods We examined preclinical and clinical data reported in various studies from the available literature concerning the effects of DHEA in normal and pathological conditions. Main Outcome Measures Data reported in the literature were analyzed, reviewed, and discussed. Results DHEA mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors. These pathways include: nitric oxide synthase activation, modulation of γ-amino butyric acid receptors, N-methyl D-aspartate, receptors sigma receptors (Sigma-1), differential expression of inflammatory factors, adhesion molecules and reactive oxygen species, among others. Clinical and epidemiological studies suggested that low DHEA levels might be associated with ischemic heart disease, endothelial dysfunction, atherosclerosis, bone loss, inflammatory diseases, and sexual dysfunction. Most importantly, no significant adverse or negative side effects of DHEA were reported in clinical studies of men and women. Conclusion DHEA modulates endothelial function, reduces inflammation, improves insulin sensitivity, blood flow, cellular immunity, body composition, bone metabolism, sexual function, and physical strength in frailty and provides neuroprotection, improves cognitive function, and memory enhancement. DHEA possesses pleiotropic effects and reduced levels of DHEA and DHEA-S may be associated with a host of pathologies; however, the clinical efficacy of DHEA supplementation in ameliorating patho-physiological symptoms remains to be evaluated.

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“…DHEA-sulfate and DHEA exist in serum and are the most abundant circulating hormones secreted from the adrenal cortex. Serum levels of DHEA decline with age, and significance was suggested in the pathological progress of cardiovascular dynsfunction 43) . Similar to E2, recent studies suggest an important role for DHEA in vascular diseases.…”

Section: Pp2amentioning

confidence: 99%

Roles of Oxidative Stress and Redox Regulation in Atherosclerosis

Kondo

Hirose

Kageyama

2009

JAT

120

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Oxidative stress is believed to be a cause of aging and cardiovascular disorders. In response to inflammation or endothelial cell injury, production of reactive oxygen species (ROS) is enhanced in vascular cells. These changes contribute to the initiation of atherosclerosis. Vascular cells possess anti-oxidant systems to protect against oxidative stress, in addition to the redox system. The redox status of protein thiols is important for cellular functions. The Akt signaling pathway exerts effects on survival and apoptosis, and is regulated by the glutathione (GSH)/glutaredoxin (GRX)-dependent redox system. Sex hormones such as estrogens protect against oxidative stress by protecting the Akt signaling pathway but the physiological role of the extracellular GSH/GRX system has not been clarified, although found an increase in the levels of S-glutathionylated serum proteins in patients with atherosclerosis obliterans. The results suggested that impaired serum redox potential is a marker of the development vascular dysfunction and estrogen has a possible role in the prevention of atherosclerosis. eNOS and its level is regulated by guanosine triphosphate cyclohydrolase 1, a rate-limiting enzyme in BH4 synthesis, and the redox state of BH4. Under oxidative stress, BH4 is oxidized to form 7,8-dihydropterin (BH2) and biopterin, both incapable of eNOS catalysis. The redox regulation of BH4 and BH2 seems clinically important, although, the precise mechanism is not clear 6,7)

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Association of Plasma Dehydroepiandrosterone-Sulfate Levels with Endothelial Function in Postmenopausal Women with Coronary Risk Factors

Cited by 24 publications

References 36 publications

Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME)

Roles of Oxidative Stress and Redox Regulation in Atherosclerosis

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