Association of Plasma Homocysteine Level and Arterial Stiffness in Subjects with Type 2 Diabetes Mellitus

Hwang, Jenie Yoonoo; Jung, Chang Hee; Lee, Min Jung; Kang, Yu Mi; Lee, Woo Je; Park, Joong Yeol

doi:10.12997/jla.2013.2.1.27

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…The statistical positive significant correlation between Hcy and MDA levels that obtained in study is agreed with some previous studies [6][7][8][9][10][11] that shows positive correlation between Hcy and MDA levels (p<0.05). The exact mechanism of toxicity by Hcy is still unknown well, but it's believed that homocysteine or compounds liberated from its metabolize enhancing atherosclerosis by several mechanisms for example the hydrogen peroxide generated by auto oxidation of homocysteine which affect toxically on endothelial cells [11][12][13] .…”

Section: Discussionsupporting

confidence: 92%

“…The results of many clinical and epidemiological studies have been showed a positive correlation between pathogenesis of CAD and increasing homocysteine levels. Few studies have been carried out to established correlation between homocysteine and oxidative stress in diabetic patients with and without CAD [6][7][8][9][10] . Therefore the study has been current to establish the correlation of hyperhomocysteinemia with oxidative stress as one of the risk factors for coronary artery disease in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Relation of Homocysteine With Malondialdehyde and Dyslipidemia in Type 2 Diabetic Patients with Coronary Artery Diseases

2020

IJFMT

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Diabetes mellitus(DM) is one of the most common chronic disorder widely prevalent throughout the world. DM is characterized by elevation of blood glucose (hyperglycemia). Hyperglycemia, with time, led to several serious macro and mircovascular complications.The purpose of study was to investigate the relation of Homocysteine(Hcy) with oxidative stress (malondialdehyde"MDA") and dyslipidemia in type 2 diabetic patients with coronary artery diseases in comparison to patients of coronary artery diseases(CAD) without DM.Methods: The present study included 60 patients of coronary artery disease. Patients divided into two groups: group1 = 30 coronary artery disease patients without diabetic and group2 = 30 coronary artery disease patients with type2 diabetes. Homocysteine was estimated by competitive ELISA test using commercially available kit. MDA was estimated by colorimetric method. Lipid profiles were determined by using commercial available kits.Results: Plasma levels of Hcy and MDA in group1 and group2 were significantly higher (p<0.05) than controls. In group1 Hcy shows significant (P<0.05) positive correlation with MDA and Total Cholesterol (TC). Hcy shows no significant (p>0.05) positive correlation with very low density lipoprotein (VLDL), low density lipoprotein (LDL),and Triglyceride(TG). Hcy shows negative significant (p<0.05)correlation with high density lipoprotein( HDL). While in group2 Hcy shows significant (P<0.05) positive correlation with MDA, TC, VLDL, LDL and TG. Hcy shows negative significant (p<0.05)correlation with HDL. Hcy, MDA, TC, TG, LDL and VLDL were higher without significant in CAD diabetic patients than non-diabetic CAD patients. HDL was lower in diabetic coronary artery disease patients than non-diabetic coronary artery disease patients but without significant importance. Conclusion:In this study Hcy and MDA levels obtained were found to be positively correlated with dyslipidemia in patients in both groups. Hcy may be one of the cause for development and progress of macro-and microvascular disease. Hcy, MDA and dyslipidemia were higher in CAD with DM than CAD without DM this shows that hyperglycemia may be is another factor to increase atherosclerotic process.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Relation of Homocysteine With Malondialdehyde and Dyslipidemia in Type 2 Diabetic Patients with Coronary Artery Diseases

2020

IJFMT

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“…In addition, Kinouchi et al 39 mentioned that HbA1c level was associated with an increased baPWV. Furthermore, many studies reported a positive correlation between HbA1c and artificial stiffness [40][41][42] . Therefore, we can use an invasive index, such as baPWV, as a cardiovascular risk factor.…”

Section: Discussionmentioning

confidence: 99%

Independent association between glycated hemoglobin and arterial stiffness in healthy men

Noh

Kim

Seo

et al. 2015

J of Diabetes Invest

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Aims/IntroductionMany studies have reported that high levels of glycated hemoglobin (HbA1c) are strongly associated with an increased risk of cardiovascular disease. Many researchers have not studied the association of HbA1c with various subclinical atherosclerosis phenotypes. We evaluated the impact of HbA1c on arterial stiffness and atherosclerosis in healthy Korean healthy men.Materials and MethodsThe study population included healthy adult men who participated in health check‐ups. All participants fasted for at least 8 h before taking the blood sample for fasting blood glucose, HbA1c, total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol and triglyceride. Arterial stiffness was measured using brachial‐ankle pulse wave velocity. Hierarchical regression analysis allowed us to determine the relationship between brachial‐ankle pulse wave velocity (baPWV) and potential risk factors for cardiovascular disease.ResultsAge and HbA1c were significantly related to baPWV, in model 1. In model 2, blood pressure was added to model 1. Systolic blood pressure was a more significant variable, which was more affected on baPWV than diastolic blood pressure. In the case of model 3, we included all variables regarding arterial stiffness. According to model 3, the most explainable variable was age, and then systolic blood pressure, body mass index and triglyceride, respectively.ConclusionsWe analyzed the associations between HbA1c, which is one of the risk factors, and arterial stiffness independently. An arterial stiffness measurement using baPWV can show the level of severity of the arteriosclerosis. When the level of stiffness has been increased, we could assume that the risk of arteriosclerosis would be increased. It can also be related to the increase of the risk of cardiovascular disease.

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“…https://doi.org/10.21561/jor.2024.9.1.10 이 세포사멸을 유도하는 신경독소로 작용하여 황반병증 [11][12][13], 개방각녹내장 [14], 당뇨망막병증 [15]과 연관이 있다고 밝혀졌으 며, 혈청 호모시스테인의 농도 증가에 따라 망막혈관폐쇄성 질 환의 독립적 위험인자로 알려져 있다 [16][17][18][19]. 망막정맥폐쇄는 당뇨망막병증에 이어 두 번째로 흔한 망막혈 관 질환으로 폐쇄 위치에 따라 망막중심정맥폐쇄(central retinal vein occlusion)와 망막분지정맥폐쇄(branch retinal vein occlusion) 로 구분되며, 이는 임상 경과와 시력 예후에 차이를 가진다 [20,21].…”

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Associations of Peripapillary Retinal Nerve Fiber Layer and Macular Retinal Layer Thickness with Serum Homocysteine Concentration

Kim,

Lee,

Baek

2024

J Retin

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Purpose:The purpose of this study is to investigate peripapillary retinal nerve fiber layer (RNFL) and macular retinal layer thickness according to serum homocysteine concentration. Methods: Serum homocysteine levels of 120 retinal vein occlusion patients were measured. Peripapillary RNFL thickness and macular retinal layer thickness of unaffected eyes were measured by spectral domain optical coherence tomography and analyzed. Results: Average peripapillary RNFL thickness thinning (86.18 ± 19.78 µm vs. 99.61 ± 17.21 µm) (p < 0.001) and all quadrant (superior, nasal inferior, temporal) of peripapillary RNFL thickness thinning were observed in hyperhomocysteinemia patients. Average central macular thickness (CMT) (266.01 ± 29.59 µm vs. 278.71 ± 25.17 µm) was thinner in hyperhomocysteinemia patients (p = 0.029). Thinning of the macular nerve fiber layer (11.71 ± 3.46 µm vs. 14.35 ± 9.03 µm) and inner nuclear layer (25.45 ± 9.84 µm vs. 30.94 ± 13.88 µm) were also observed (p = 0.022, p = 0.041, respectively). There was a negative correlation between serum homocysteine and peripapillary RNFL thickness (r = -0.223, p = 0.015), and CMT (r = -0.230, p = 0.012), especially of the inner retinal layer. Conclusions: This study found associations of serum homocysteine with peripapillary RNFL and macular retinal layer thickness.

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Association of Plasma Homocysteine Level and Arterial Stiffness in Subjects with Type 2 Diabetes Mellitus

Cited by 3 publications

References 27 publications

Relation of Homocysteine With Malondialdehyde and Dyslipidemia in Type 2 Diabetic Patients with Coronary Artery Diseases

Relation of Homocysteine With Malondialdehyde and Dyslipidemia in Type 2 Diabetic Patients with Coronary Artery Diseases

Independent association between glycated hemoglobin and arterial stiffness in healthy men

Associations of Peripapillary Retinal Nerve Fiber Layer and Macular Retinal Layer Thickness with Serum Homocysteine Concentration

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