Association of Plasma Interleukin-18 Levels with Emotion Regulation and μ-Opioid Neurotransmitter Function in Major Depression and Healthy Volunteers

Prossin, Alan R.; Koch, Alisa E.; Campbell, Phillip L.; McInnis, Melvin G.; Zalcman, Steven S.; Zubieta, Jon Kar

doi:10.1016/j.biopsych.2010.10.014

Cited by 66 publications

(54 citation statements)

References 20 publications

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“…The concentrations of other cytokines (e.g., EGF; 100-400 pg/mL) are lower than that of NRG1 (7.21 ± 1.11 ng/mL) [26]. Although Tanaka et al reported a specific reduction of plasma IL-16 in patients with schizophrenia [27], subsequent research found a significant decrease in the plasma IL-16 levels of patients with major depressive disorder [28]. In the present study, NRG1␤1 exhibited a specific decrease in the participants with first-episode schizophrenia and chronic schizophrenia compared with the healthy controls, but no significant changes were detected in the participants with bipolar disorder or major depressive disorder compared with the healthy controls.…”

Section: Discussionmentioning

confidence: 91%

Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia

Wang

et al. 2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 91%

Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia

Wang

et al. 2015

Neuroscience Letters

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“…The T1ρ within these three specific brain regions was hypothesized a priori to be correlated with specific inflammatory protein concentrations based on the extant literature identifying dysregulated processing of emotionally salient and stressful events as well as hypothesized sensitivity to cytokine-induced depression (Dantzer et al, 2008) and human evidence of neuro-immune interactions (Prossin et al, 2011; Prossin et al, 2015). Exploratory analyses assessed correlations between other inflammatory proteins and these regions as well as two other specific regions of interest component to (or with significant projections to) cortico-limbic circuitry, the anterior cingulate and middle frontal gyrus.…”

Section: Methodsmentioning

confidence: 99%

Peripheral inflammation during abnormal mood states in bipolar I disorder

Fiedorowicz

Prossin

Johnson

et al. 2015

Journal of Affective Disorders

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Background Bipolar disorder carries a substantive morbidity and mortality burden, particularly related to cardiovascular disease. Abnormalities in peripheral inflammatory markers, which have been commonly reported in case-control studies, potentially link these co-morbidities. However, it is not clear whether inflammatory markers change episodically in response to mood states or are indicative of chronic pro-inflammatory activity, regardless of mood, in bipolar disorder. Methods Investigations focused on comparing concentrations of specific inflammatory cytokines associated with immune activation status (primary outcome = tumor necrosis factor alpha (TNF-α)) in 37 participants with bipolar disorder across 3 mood states (mania N=15, depression N=9, normal mood N=13) and 29 controls without a psychiatric disorder (total N=66). Cytokine levels were also compared to T1ρ, a potential neuroimaging marker for inflammation, in select brain regions in a subsample (N=39). Results Participants with bipolar disorder and healthy controls did not differ significantly in inflammatory cytokine concentrations. However, compared to cases with normal mood, cases with abnormal mood states (mania and depression) had significantly elevated levels of TNF-α, its soluble receptors (sTNFR1/sTNFR2), other macrophage-derived cytokines (interleukin 1β (IL-1β), IL-6, IL-10, IL-18) in addition to IL-4, interferon-γ, monocyte chemotactic protein-1, fibroblast growth factor β, and vascular endothelial growth factor. Cytokine levels were not correlated with signals from T1ρ imaging in selected structures (amygdalae, hippocampi, hypothalamus, anterior cingulate gyrus, middle frontal gyrus). Limitations Participants were not followed prospectively across mood states. Conclusion Activation of inflammatory markers was found in abnormal mood states of bipolar disorder. Longitudinal study of individuals with mood disorders is needed to confirm these findings and to elucidate the time course of any such changes.

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“…IL-18 is a proinflammatory cytokine and a new member of the IL-1 family that has been found elevated in depressed patients 18,19 and also in depression after stroke. 34 In a study by Prossin et al, 35 IL-18 elevation was observed in depressed patients. This finding is consistent with previous studies showing proinflammatory cytokine elevation in depressed patients.…”

Section: Discussionmentioning

confidence: 97%

Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation

Sahraei

Eshraghi

Eslami

et al. 2016

American Journal of Therapeutics

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Renal transplantation is the treatment of choice for many patients with end-stage renal disease. Because there is little information about depression after kidney transplantation, we investigated frequency and determinant factors of depression and also its association with interleukin (IL)-18. Kidney transplant recipients were investigated between January 2011 and February 2013. Depression was assessed using the Beck Depression Inventory (BDI, BDI-II). We investigated the relationship between 1-year posttransplantation depression and all-cause mortality, acute kidney injury, and serum creatinine 1, 3, and 12 months after transplantation. Furthermore, the association of depression with IL-18 biomarker was recorded 1 year after transplantation. A total of 74 patients (age: 37.06 ± 16.2 years; 59.5% male) were enrolled in this study 1 year after transplantation. Nineteen (25.6%), 2 (2.7%), and 1 (1.3%) of them experienced mild, moderate, and severe depression, respectively. IL-18 biomarker (independent variable) was significantly associated with depression 1 year after transplantation. Our data suggested that IL-18 level increased significantly in renal transplant patients with depression.

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Association of Plasma Interleukin-18 Levels with Emotion Regulation and μ-Opioid Neurotransmitter Function in Major Depression and Healthy Volunteers

Cited by 66 publications

References 20 publications

Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia

Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia

Peripheral inflammation during abnormal mood states in bipolar I disorder

Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation

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