Association of Plasma Levels of F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) With Human Atherosclerosis

Abstract

Plasma F11R is independently associated with the presence and severity of angiographically defined CAD. By virtue of its strong correlation to plasma TNF-alpha, F11R may be an important mediator of the effects of inflammation on the vessel wall. Strategies that block F11R may represent a novel approach to the treatment of human atherosclerosis.

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

“…Indeed, recent ELISA measurements demonstrated elevated JAM-A concentrations in serum samples of patients with atherosclerotic disease, and these increased levels of JAM-A correlated with high serum levels of TNF-␣, suggesting a common mechanism for the release of these molecules. 35 As we demonstrate here, systemic TNF-␣ and IFN-␥ induce release of soluble JAM-A in mice. Although the serum levels are relatively low (in the nanomolar range), JAM-A may occur at higher local concentrations within the inflamed blood vessel wall at sites of JAM-A expression and cleavage.…”

Elevated Plasma Level of Soluble F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) in Hypertension

“…8 Plasma sF11R levels were also elevated in CAD patients. 9 Since the activity of F11R in initiating plaque formation leading to atherosclerosis…”

‘Outside the box’ genes, transcriptions and translations in Rheumatoid arthritis

“…It is implicated in transendothelial migration of leukocytes after cytokine stimulation, hence assumes significance in inflammatory disorders and atherosclerosis. 4 The study by Tzu-Jung Fang et al from Taiwan have examined the association of F11R promoter polymorphism and development of RA. It is a novel association not previously explored in RA.…”