Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study

Zhu, Cairong; Li, Guangzong; Lv, Zhiyu; Li, Jing; Wang, Xiangming; Kang, Jie; Zhan, Cheng

doi:10.1007/s10072-019-04040-w

Cited by 46 publications

(39 citation statements)

References 34 publications

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“…15 Likewise, several clinical studies also emphasize the adverse impact of TMAO on cognitive function in Alzheimer's disease and poststroke patients. 35,36 Our results are consistent with these prior findings and highlight the effect of TMAO on the overall condition of the older population by focusing on cognitive frailty because studies have shown that older adults with cognitive frailty have a worse prognosis than those with cognitive impairment only. 37 Currently, only long-term physical activity can reduce cognitive frailty, 38 and neither a biomarker nor a targeted intervention for cognitive frailty has been proposed.…”

Section: Figuresupporting

confidence: 91%

<p>Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease</p>

He¹,

Luo²,

Liu³

et al. 2020

CIA

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Objective: Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease. Patients and Methods: This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a frailty index constructed with 48 variables according to the cumulative deficits model. Physical frailty and cognitive frailty were also assessed in detail. Fasting plasma TMAO was measured by mass spectrometry. Results: The proportion of frail subjects was 29.9% (135/451). Plasma TMAO levels were significantly higher in frail patients than in nonfrail individuals (4.04 [2.84-7.01] vs 3.21 [2.13-5.03] µM; p<0.001). Elevated plasma TMAO levels were independently associated with the likelihood of frailty (OR 2.12, 95% CI 1.01-4.38, p=0.046). Dose-response analysis revealed a linear association between the TMAO concentration and the OR for frailty. A 2-unit increase in TMAO was independently correlated with physical frailty (OR 1.23, 95% CI 1.08-1.41, p for trend 0.002) and cognitive frailty (OR 1.21, 95% CI 1.01-1.45, p for trend 0.04). Conclusion: Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.

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Section: Figuresupporting

confidence: 91%

<p>Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease</p>

He¹,

Luo²,

Liu³

et al. 2020

CIA

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“…MMSE is the most commonly used cognitive screening instrument and is convenient for clinical use with its high sensitivity and specificity for dementia . Despite of its poor sensitivity for mild cognitive impairment, MMSE has been widely applied to assess the cognitive impairment in stroke patients . The MMSE has been translated into Chinese and validated for reliability and validity as a screening tool for cognitive impairment in the Chinese population.…”

Section: Methodsmentioning

confidence: 99%

“…22 Despite of its poor sensitivity for mild cognitive impairment, MMSE has been widely applied to assess the cognitive impairment in stroke patients. 23,24 The MMSE has been translated into Chinese and validated for reliability and validity as a screening tool for cognitive impairment in the Chinese population. The maximum score for the MMSE is 30.…”

Section: Assessmentmentioning

confidence: 99%

Hemoglobin, anemia, and poststroke cognitive impairment: A cohort study

Ruan

Yuan

et al. 2020

Int J Geriat Psychiatry

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Objectives Several studies have demonstrated that anemia was associated with cognitive impairment. The aim of this study was to explore the relationship between hemoglobin and cognitive impairment in patient with acute ischemic stroke. Methods In total, 326 patients with acute ischemic stroke were followed up for 1 month. The main outcome was the incidence and severity of poststroke cognitive impairment (PSCI) assessed by Mini‐Mental State Examination (MMSE). The impact of hemoglobin levels and anemia on PSCI was assessed by multiple regression models controlling for potential confounders. Results During the 1‐month follow‐up, 193 (59.2%) patients developed PSCI. Anemia was independently associated with PSCI (OR = 3.637; 95% CI, 1.216‐10.881; P = .021) after adjusting for demographics, vascular risk factors, stroke severity, and functional outcome. When the hemoglobin levels stratified into tertiles, higher hemoglobin levels were associated with better cognitive function. This result was however not significant after adjusting for the same confounders above. Conclusions Low hemoglobin levels are associated with an increased risk of PSCI. Targeted interventions in this population may reduce the incidence of PSCI and require further evaluation.

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“…We selected 21 data-based studies testing plasma, serum, or urine for review. The studies examined cardiovascular (Amin et al, 2019; Hayashi et al, 2018; Liu et al, 2018; Matsuzawa et al, 2019; Nie et al, 2018; Walejko et al, 2018; Zhai et al, 2019; Zhu et al, 2020), respiratory (Ottiger et al, 2018), and autoimmune (Bellocchi et al, 2018) disorders as well as diabetes (Li et al, 2018; Liu, Ling, et al, 2017; Tuomainen et al, 2018; Urpi-Sarda et al, 2019), obesity (Liu, Hong et al, 2017; Ottosson et al, 2018; Serena et al, 2018), and human immunodeficiency (HIV) infection (Missailidis et al, 2018; Moon et al, 2018; Shan et al, 2018; Wang et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…After a nonST-segment myocardial infarction, chronically elevated plasma TMAO levels predicted future cardiovascular events (median follow-up of 5 years; Matsuzawa et al, 2019). Serum and plasma TMAO levels were associated with the risk for stroke in hypertensive patients (Nie et al, 2018) as well as adverse outcomes following stroke, such as cognitive impairments (Zhai et al, 2019; Zhu et al, 2020). Increased plasma TMAO levels predicted all-cause mortality in patients with chronic obstructive pulmonary disease, but the association was not significant after controlling for comorbidities and age (Ottiger et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

Diallo

Lockwood

Maki

et al. 2020

Biological Research For Nursing

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The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients’ symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.

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Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study

Cited by 46 publications

References 34 publications

<p>Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease</p>

<p>Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease</p>

Hemoglobin, anemia, and poststroke cognitive impairment: A cohort study

Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

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