Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components

Li, Wenzhen; Chen, Dajie; Peng, Ying; Lu, Zuxun; Wang, Dongming

doi:10.1002/oby.23691

Cited by 19 publications

(5 citation statements)

References 42 publications

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“…Overall, we observed associations between 1-hydroxynaphthalene, mono-3-carboxypropyl phthalate and differential placenta methylation, which could lead to alterations in fatty acid metabolism, genetic information processing and organismal systems. Similar results have been presented in the literature, suggesting associations between PAH metabolites and metabolic syndrome, cardiovascular conditions, and systemic inflammation [ 62 , 63 ]. Additionally, a mice-based study suggested prenatal exposure to PAHs and their associated multi-generational (offspring and grand-offspring) epigenetic effects [ 64 ].…”

Section: Discussionsupporting

confidence: 90%

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

Puvvula,

Braun,

DeFranco

et al. 2024

Epigenetics Commun.

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Background Exposure to environmental chemicals such as phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs) during pregnancy can increase the risk of adverse newborn outcomes. We explored the associations between maternal exposure to select environmental chemicals and DNA methylation in cord blood mononuclear cells (CBMC) and placental tissue (maternal and fetal sides) to identify potential mechanisms underlying these associations. Method This study included 75 pregnant individuals who planned to give birth at the University of Cincinnati Hospital between 2014 and 2017. Maternal urine samples during the delivery visit were collected and analyzed for 37 biomarkers of phenols (12), phthalates (13), phthalate replacements (4), and PAHs (8). Cord blood and placenta tissue (maternal and fetal sides) were also collected to measure the DNA methylation intensities using the Infinium HumanMethylation450K BeadChip. We used linear regression, adjusting for potential confounders, to assess CpG-specific methylation changes in CBMC (n = 54) and placenta [fetal (n = 67) and maternal (n = 68) sides] associated with gestational chemical exposures (29 of 37 biomarkers measured in this study). To account for multiple testing, we used a false discovery rate q-values < 0.05 and presented results by limiting results with a genomic inflation factor of 1±0.5. Additionally, gene set enrichment analysis was conducted using the Kyoto Encyclopedia of Genes and Genomics pathways. Results Among the 29 chemical biomarkers assessed for differential methylation, maternal concentrations of PAH metabolites (1-hydroxynaphthalene, 2-hydroxyfluorene, 4-hydroxyphenanthrene, 1-hydroxypyrene), monocarboxyisononyl phthalate, mono-3-carboxypropyl phthalate, and bisphenol A were associated with altered methylation in placenta (maternal or fetal side). Among exposure biomarkers associated with epigenetic changes, 1-hydroxynaphthalene, and mono-3-carboxypropyl phthalate were consistently associated with differential CpG methylation in the placenta. Gene enrichment analysis indicated that maternal 1-hydroxynaphthalene was associated with lipid metabolism and cellular processes of the placenta. Additionally, mono-3-carboxypropyl phthalate was associated with organismal systems and genetic information processing of the placenta. Conclusion Among the 29 chemical biomarkers assessed during delivery, 1-hydroxynaphthalene and mono-3-carboxypropyl phthalate were associated with DNA methylation in the placenta.

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Section: Discussionsupporting

confidence: 90%

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

Puvvula,

Braun,

DeFranco

et al. 2024

Epigenetics Commun.

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“…An in vitro study also suggests that cadmium can induce malignant prostate tumors ( 2 , 8 , 29 ). Chronic inflammation caused by beryllium is considered a possible contributor to the carcinogenicity of beryllium to humans ( 24 , 48 ). Currently, there is no research analyzing the synergistic effects of Cd and depression on PSA, and in an era where mental health has a significant impact, further research on the mechanisms and preventive measures is warranted ( 12 , 14 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

Ren,

Zhang,

2024

Front. Public Health

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ObjectiveThis study aims to investigate the impact of depression and urinary metals on Prostate-Specific Antigen (PSA).MethodsAnalysis was conducted on 1901 samples collected from the National Health and Nutrition Examination Survey (NHANES) database between 2001 and 2010. Analytical methods included stepwise multiple linear regression (MLR) analysis of the overall population’s urinary metals and PSA relationship, analysis of urinary metals and PSA relationship in older adults and BMI subgroups, analysis of urinary metals and PSA relationship in the depressed population, and restricted cubic spline (RCS) analysis. A significance level of p < 0.05 was considered statistically significant.ResultsIn the stepwise multiple linear regression, beryllium (Be) showed a dose–response association with PSA (third quartile: β = 0.05, 95%CI (0.02, 0.09); fourth quartile: β = 0.07, 95%CI (0.02, 0.12), p trend = 0.048). Subgroup analysis indicated that in individuals aged >60, Be at Q4 level [β = 0.09, 95%CI (0.05, 0.21)] exhibited a dose–response correlation with PSA. In the population with 25 ≤ BMI < 30, Be might more significantly elevate PSA, with Q4 level having a pronounced impact on PSA levels [β = 0.03, 95%CI (0.02, 1.27)]. In the depressed population, urinary cadmium (Cd) levels showed a significant positive dose–response relationship, with Q4 level of Cd having the maximum impact on PSA [β = 0.3, 95%CI (0.09, 0.49)].ConclusionIndividuals exposed to beryllium (Be), especially the older adults and overweight, should monitor their PSA levels. In depressed patients, cadmium (Cd) levels may further elevate PSA levels, necessitating increased monitoring of PSA levels among males.

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“…Similar findings were observed among drinkers, which may be due to the higher concentration of metals according to our results. Besides, the ORs of total mercury and LTBI in adults and blood manganese with LTBI in adolescents were different in sociodemographic characteristics, which implied more concerns should be given to certain population (29,37,38).…”

Section: Discussionmentioning

confidence: 99%

The association of blood metals with latent tuberculosis infection among adults and adolescents

Wu,

Wang,

Tao

et al. 2023

Front. Nutr.

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ObjectiveWe aimed to investigate the relationship of metal exposure and latent tuberculosis infection (LTBI) among US adults and adolescents.MethodsParticipants from the National Health and Nutrition Examination Surveys (NHANES 2011 ~ 2012) were included. Multiple logistic regression models were used to explore the associations between metal exposure and LTBI. A total of 5,248 adults and 1,860 adolescents were included in the present analysis.ResultsFor adults, we only found a positive association between total mercury and LTBI (OR: 1.411; 95% CI: 1.164 ~ 1.710) when used as a continuous variable. Compared with Q1, Q4 increased the prevalence of LTBI (2.303; 1.455 ~ 3.644) when used as a quartile. The OR of total mercury and LTBI was higher among females (1.517; 1.009 ~ 2.279), individuals aged 45 ~ 64 (1.457; 1.060 ~ 2.002), and non-Hispanic White individuals (1.773; 1.316 ~ 2.388). A relationship was observed among only participants with obesity (1.553; 1.040 ~ 2.319) or underweight (1.380; 1.076 ~ 1.771), with college or above (1.645; 1.184 ~ 2.286), with PIR > 3.0 (1.701; 1.217 ~ 2.376), reported smoking (1.535; 1.235 ~ 1.907) and drinking (1.464; 1.232 ~ 1.739). For adolescents, blood manganese was positively associated with LTBI. The OR and 95% CIs for each one-unit increase in the log-transformed level of blood manganese with LTBI were 9.954 (1.389 ~ 71.344).ConclusionSignificant associations were observed in girls, aged ≥12 years and in the non-Hispanic white population. In conclusion, total mercury is associated with an increased prevalence of LTBI among adults and positive association between blood manganese and LTBI was observed among adolescents. Further studies should be conducted to verify the results and explore potential biological mechanisms.

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Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components

Cited by 19 publications

References 42 publications

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

Association between urinary metals and prostate-specific antigen in aging population with depression: a cross-sectional study

The association of blood metals with latent tuberculosis infection among adults and adolescents

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