Association of polymorphic variants of  IL-1β  and  IL-1RN  genes in the development of Graves’ disease in Kashmiri population (North India)

Shehjar, Faheem; Afroze, Dil; Misgar, Raiz Ahmad; Malik, Sajad Ahmad; Laway, Bashir Ahmad

doi:10.1016/j.humimm.2018.02.006

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Studies have shown that IL-1 can play an important role in autoimmune diseases, especially in the onset of Hashimoto's thyroiditis. 19,20 However, the results of this study show that the difference between the study group and control group in the level of IL-1 was not statistically significant, suggesting that the influence of vitamin D deficiency on thyroid function and immune status may have nothing to do with IL-1.…”

Section: Discussioncontrasting

confidence: 60%

Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Zhou

Wang

et al. 2020

Pak J Med Sci

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Objective: To investigate the effect of vitamin D deficiency on the levels of thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPO-Ab), interleukin-1 (IL-1) and high-sensitivity C-reactive protein (hs-CRP) in pregnant women with early pregnancy complicated by subclinical hypothyroidism. Methods: A total of 172 pregnant women with subclinical hypothyroidism in the first trimester diagnosed and treated in a given hospital from August 2014 to May 2018 were selected, and their levels of vitamin D were determined. Depending on the abnormality of their vitamin D levels, the study participants were divided into two groups: the study group (vitamin D≤20 ng/L) and the control group (vitamin D>20 ng/L). The levels of TSH, TPO-Ab, IL-1 and hsCRP in the two groups were measured. Results: The levels of TSH, hsCRP and TPO-Ab in the study group were significantly higher than those in the control group (P < 0.05). The comparison between the two groups in terms of IL-1 showed no statistically significant difference. Conclusion: Vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. The mechanism may be associated with the impact of vitamin D deficiency on hs-CRP and other body inflammation indicators, as well as on thyroid autoantibodies and other immune indicators, but has no effect on IL-1 levels. doi: https://doi.org/10.12669/pjms.36.6.1982 How to cite this:Zhou X, Li B, Wang C, Li Z. Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.1982 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 60%

Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Zhou

Wang

et al. 2020

Pak J Med Sci

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“…Thyroid gland autoimmune disorders also appear informative. (i) A recent large-scale study found an association with the IL-1 RN (gene encoding the IL-1Ra) receptor antagonist variable number of tandem repeats (VNTR) polymorphism in Hashimoto Thyroiditis (HT) patients (45); (ii) increased percentages of circulating Tfh cells have been found in patients with autoimmune thyroid disorders, with a positive correlation between the percentages of circulating Tfh cells and the serum concentrations of anti-TSH receptor-Ab/thyroperoxidase-Ab/thyroglobulin-Ab (46); (iii) a study suggested that both promoter and exon polymorphisms of IL-1β gene have a significant role in the risk of developing Graves' disease (GD) (47); (iv) although no significant differences in IL-1β levels were found between serum from patients with HT or GD and normal controls. IL-1β mRNA and protein levels in peripheral blood mononuclear cells of HT patients were found to be significantly higher than those of patients with GD, which were in turn higher than the level in normal controls; (v) IL-1β mRNA was also increased in thyroid gland tissue from patients with HT compared to those with GD, and this was accompanied by increased local infiltration of monocytes into thyroid tissues; correlation analysis validated the association of high IL-1β levels with the pathogenesis of HT and led to the suggestion that IL-1β may be an active etiologic factor in the pathogenesis of HT and thus represent a new target for novel diagnostics and treatment (48).…”

Section: Il-1 and The Pathophysiology Of Humoral Responsesmentioning

confidence: 99%

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells

Ritvo

Klatzmann

2019

Front. Immunol.

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The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving interleukin-1 receptors (IL-1R1 and IL-1R2) and receptor antagonists (IL-1Ra). Here, we revisit the literature on this topic and conclude that targeting the interleukin-1 pathway should be a valuable therapeutic approach in many diseases involving excessive production of (auto)antibodies, such as autoimmune diseases or allergy.

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“…Genetic variations in the promoter region of genes encoding cytokines were shown to correlate with individual differences in the expression of respective cytokines which may influence the intensity of the inflammatory response and susceptibility to many diseases [31][32][33][34][35]. IL-1B gene has two allelic variants (CT; dbSNP: rs16944) and (TC; dbSNP: rs1143627) which are located at positions − 511 and − 31, respectively, in the promoter region.…”

Section: Introductionmentioning

confidence: 99%

First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach

Idris

Idris²,

Ataelmanan

et al. 2021

BMC Microbiol

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Background Helicobacter pylori (H. pylori) infects nearly half of the world’s population with a variation in incidence among different geographic regions. Genetic variants in the promoter regions of the IL1B gene can affect cytokine expression and creates a condition of hypoacidity which favors the survival and colonization of H. pylori. Therefore, the aim of this study was to characterize the polymorphic sites in the 5′- region [−687_ + 297] of IL1B in H. pylori infection using in silico tools. Results A total of five nucleotide variations were detected in the 5′-regulatory region [−687_ + 297] of IL1B which led to the addition or alteration of transcription factor binding sites (TFBSs) or composite regulatory elements (CEs). Genotyping of IL1B − 31 C > T revealed a significant association between -31 T and susceptibility to H. pylori infection in the studied population (P = 0.0363). Comparative analysis showed conservation rates of IL1B upstream [−368_ + 10] region above 70% in chimpanzee, rhesus monkey, a domesticated dog, cow and rat. Conclusions In H. pylori-infected patients, three detected SNPs (− 338, − 155 and − 31) located in the IL1B promoter were predicted to alter TFBSs and CE, which might affect the gene expression. These in silico predictions provide insight for further experimental in vitro and in vivo studies of the regulation of IL1B expression and its relationship to H. pylori infection. However, the recognition of regulatory motifs by computer algorithms is fundamental for understanding gene expression patterns.

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Association of polymorphic variants of IL-1β and IL-1RN genes in the development of Graves’ disease in Kashmiri population (North India)

Cited by 9 publications

References 22 publications

Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells

First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach

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