Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population

Wang, Xiujun; Zhong, Yi; Jj, Bao; Sj, Dou; Wy, Wu; Qiang, Jun

doi:10.3724/sp.j.1005.2011.00048

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…These studies were then filtered to ensure conformity with the inclusion criteria. Four studies (Foley et al, 2004;Galeeva et al, 2002;Pastorelli et al, 2001) were excluded because no diagnostic criteria was described explicitly; one study (Munafo et al, 2005) because it was investigating social 'drinkers' rather than alcohol-dependent or abusing subjects; one study (Rasmussen et al, 2009) because it investigated alcohol and cigarette consumption rather than dependence or abuse; three studies (Budde et al, 2010;Mingione et al, 2012;Thompson et al, 2010) because no matched control data were described; and two studies Hallikainen et al, 1999;Hammoumi et al, 1999;Hill et al, 2002;Ishiguro et al, 1999;Johann et al, 2003;Kohnke et al, 2006;Konishi et al, 2004;Kranzler et al, 2002;Lee et al, 2009;Lichtermann et al, 2000;Marques et al, 2006;Matsushita et al, 2001;Mokrovic et al, 2008;Namkoong et al, 2008;Nellissery et al, 2003;Parsian and Cloninger, 2001;Philibert et al, 2008;Preuss et al, 2001;Reese et al, 2010;Saiz et al, 2009;Samochowiec et al, 2006;Sander et al, 1998;Sander et al, 1997;Shin et al, 2009;Stoltenberg et al, 2002;Thompson et al, 2000;Wang et al, 2012;Wang et al, 2011b;Wu et al, 2008) investigated alcohol dependence or abuse. Among them...…”

Section: Resultsmentioning

confidence: 99%

Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder

Cao

Hudziak

2013

Neuropsychopharmacol

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A number of studies have reported associations between the serotonin transporter gene (SLC6A4) and alcohol, heroin, cocaine, or methamphetamine abuse. Other studies have yielded contrary results. There are a number of reasons for non-replication, including inadequate statistical power, population stratification, and poor phenotype definition. This study was to test the association using a meta-analytic approach across a variety of racial and ethnic populations. Using the genotype data of 55 studies (7999 cases, 8264 controls, and 676 families or parent-offspring trios) published in the past 15 years, we have conducted comprehensive meta-analyses to examine the associations of the 5-HTTLPR and STin2 polymorphisms with substance use disorder. The meta-analyses support the associations of 5-HTTLPR with alcohol, heroin, cocaine, and methamphetamine dependence and abuse (eg, the smallest P-values were 0.0058 with odds ratio (OR) ¼ 0.54 (0.35, 0.84); 0.0024 with OR ¼ 0.77 (0.66, 0.91); 0.018 with OR ¼ 1.38 (1.06, 1.81); and 0.028 with OR ¼ 0.46 (0.23, 0.92) for alcohol, heroin, cocaine, and methamphetamine dependence/abuse, respectively). When all the phenotypes are combined, the P-value was 0.0006 with OR ¼ 0.86 (0.78, 0.94) in the combined European, Asian, and Mexican populations and P-value was 0.0028 with OR ¼ 1.41 (1.13, 1.78) in the African populations. Evidence of significant associations was also identified in other subgroup analyses regarding differently combined substance and populations. The effect sizes of 5-HTTLPR were comparable among the European, Asian, and Mexican populations, however, the risk allele was more frequent in Asians than in Europeans and Mexicans. The opposite directions of risk allele in African population might be driven by the opposite directions of risk allele in cocaine dependence. This meta-analysis supports that the association of the SLC6A4 gene with substance use disorder varies depending on substances with different risk allele frequencies in the multi-cultural populations. Further studies using larger sample size are warranted.

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Section: Resultsmentioning

confidence: 99%

Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder

Cao

Hudziak

2013

Neuropsychopharmacol

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“…A study by[54] aimed at looking at the differences in the allele frequency amongst non-alcoholic controls and alcohol-dependent patients in the Yunnan Han population. The study found significant differences in the allele frequency in alcohol-dependent patient and non-alcoholic controls.…”

Section: Discussionmentioning

confidence: 99%

Neurotransmitters in alcoholism: A review of neurobiological and genetic studies

Banerjee¹

2014

Indian J Hum Genet

114

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Recent advances in the study of alcoholism have thrown light on the involvement of various neurotransmitters in the phenomenon of alcohol addiction. Various neurotransmitters have been implicated in alcohol addiction due to their imbalance in the brain, which could be either due to their excess activity or inhibition. This review paper aims to consolidate and to summarize some of the recent papers which have been published in this regard. The review paper will give an overview of the neurobiology of alcohol addiction, followed by detailed reviews of some of the recent papers published in the context of the genetics of alcohol addiction. Furthermore, the author hopes that the present text will be found useful to novices and experts alike in the field of neurotransmitters in alcoholism.

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“…Previous genetic studies on alcoholism suggested the existence of functional variants of selected genes that influence drinking behavior and are risk factors for alcohol dependence (Hallikainen et al, 1999, Wojnar et al, 2009, Wang et al, 2011, Bach et al, 2015, Plemenitas et al, 2015). It is known that the neurobiology of alcoholism involves alterations in neurotransmitter systems, e.g., the dopaminergic system (Gilpin and Koob, 2008, Karkhanis et al, 2015, Vasconcelos et al, 2015).…”

Section: 1 Introductionmentioning

confidence: 99%

COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients

Klimkiewicz

Mach

Jakubczyk

et al. 2017

Journal of Addiction Medicine

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Background The neurobiology of alcohol dependence (AD) involves alterations in neurotransmitters and the stress response. We hypothesized that an interaction between functional variants of dopaminergic and neurotrophic genes may influence drinking in AD. Methods The relationship between alcohol consumption and single nucleotide polymorphisms (SNPs), Val66Met in the BDNF and Val158Met in the COMT, was analyzed among 281 alcohol-dependent individuals. Results Individuals carrying both the COMT Met158Met genotype and the BDNF Val66Val genotype drank more than those with other variants of these genes (p=0.039). Those who had a family history of AD also drank more than those without a family history (p = 0.048). Patients with both Met/Met genotype in the COMT Val158Met polymorphism and Val/Val genotype in the BDNF Val66Met polymorphism suffered from more health problems than those carrying other variants (p=0.030) and had lower motivation to change drinking patterns (p = 0.031). Conclusions Patients carrying both the BDNF Val66Val and COMT Met158Met variants had higher alcohol consumption. These effects may be influenced by the effects of BDNF and COMT on dopamine responses to alcohol. Motivation-enhancing strategies might benefit the group of patients identified by genotyping in this study as well as treatment aimed at reducing alcohol consumption.

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Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population

Cited by 9 publications

References 23 publications

Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder

Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder

Neurotransmitters in alcoholism: A review of neurobiological and genetic studies

COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients

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