Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China

Pan, Yan-Fei; Zhang, Jiyu; Qiu, Hui-Min; Yu, Pengpeng; Liu, Zhenzhen; Liu, Bao-Peng; Jia, Cun-Xian

doi:10.1097/ypg.0000000000000221

Cited by 6 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study has demonstrated that the rs1800532 minor allele has a protective role for men younger than 35 years and women older than 50 years, whereas it tends to be a risk factor in older men (≥50 years) [62]. In a study conducted in China, no statistically significant relationship was found in terms of rs1800532 polymorphism between suicidal and non-suicidal individuals, similar to the results of our study [63]. In studies investigating the relationship of rs1800532 polymorphism genotypes of the TPH-1 gene with suicide, it was observed that variable results were obtained across different populations.…”

Section: Discussionsupporting

confidence: 89%

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

Kilicaslan,

Cumaogullari,

Emiral

et al. 2022

J. Mens. Health

View full text Add to dashboard Cite

Background and objective: Serotonin plays an important role in the pathophysiology of aggressive behavior. Low serotonin levels and altered functions of serotonin receptors affect suicidal behavior.TPH-1, TPH-2 and SLC6A4 genes have important roles in serotonin production and degradation pathways. In this study, polymorphic variants of the TPH-1, TPH-2 and SLC6A4 genes, rs1800532, rs7305115, rs6355 and rs1386494, were investigated in 100 completed suicides and 100 healthy individuals. Materials and methods:After DNA isolation, a new polymerase chain reaction technology KASP TM (Competitive allele-specific polymerase chain reaction method), was used in the genotyping of the selected gene variants.Results: No statistically significant difference was found for the genotype and individual allele frequencies of the polymorphic variants between suicide and control groups, as well as between men and women in suicide cases. However, we observed non-significant tendencies of increased minor alleles in suicidal men for all TPH SNPs. Conclusions:More molecular genetic research studies are needed to understand the pathophysiology of suicide and to reveal its relationship with gender.

show abstract

Section: Discussionsupporting

confidence: 89%

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

Kilicaslan,

Cumaogullari,

Emiral

et al. 2022

J. Mens. Health

View full text Add to dashboard Cite

show abstract

“…Genetic analyses have indicated potential associations between variants in the TPH2 gene and neuropsychiatric disorders such as depression (Gao et al, 2012), bipolar disorder (Khanzada et al, 2017), suicidal behaviour (Pompili et al, 2017), autism (Egawa et al, 2013) and attention-deficit/hyperactivity disorder (Ottenhof et al, 2018). However, other studies in different cohorts report a lack of association with these disorders (Geissler et al, 2017;Pan et al, 2019). Discrepancies in such studies are difficult to reconcile, but not unexpected given the different cohorts used, the requirement for large sample numbers and limitations in diagnostic criteria.…”

Section: Tryptophan Hydroxylase-2mentioning

confidence: 99%

Alternative splicing in serotonergic system: Implications in neuropsychiatric disorders

2019

View full text Add to dashboard Cite

Background: The serotonergic system is a key component of physiological brain function and is essential for proper neurological activity. Numerous neuropsychiatric disorders are associated with deregulation of the serotonergic system. Accordingly, many pharmacological treatments are focused on modulation of this system. While providing a promising line of therapeutic moderation, these approaches may be complicated due to the presence of alternative splicing events for key genes in this pathway. Alternative splicing is a co-transcriptional process by which different mRNA transcripts can be produced from the same gene. These different isoforms may have diverse activities and functions, and their relative balance is often critical for the maintenance of homeostasis. Alternative splicing greatly increases the production of proteins, augmenting cell plasticity, and provides an important control point for regulation of gene expression. Aim: The objective of this narrative review is to discuss the potential impact of alternative splicing of different components of the serotonergic system and speculate on their involvement in several neuropsychiatric disorders. Conclusions: The specific role of each isoform in disease and their relative activities in the signalling pathways involved are yet to be determined. We need to gain a better understanding of the basis of alternative isoforms of the serotonergic system in order to fully understand their impact and be able to develop new effective pharmacological isoform-specific targets.

show abstract

“…The human TPH1 gene has been cloned and mapped to chromosome 11p15.3-14 (Gene ID: 7166); it has 11 exons [19,24] and consists of 444 amino acids [18].Single-nucleotide polymorphisms (SNPs) have been described in genes coding for type one and type two tryptophan hydroxylases in association with psychiatric disorders and suicidal behaviour [26][27][28][29]. There are also a few studies investigating the role of the rs211105 polymorphism in diarrhoea-predominant irritable bowel syndrome, and the digestive system [18, 21,22].…”

Section: Introductionmentioning

confidence: 99%

TPH1 gene polymorphism rs211105 influences serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

Snarska

Fiedorowicz

Rozmus

et al. 2021

Preprint

View full text Add to dashboard Cite

Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results Our data showed an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95% CI: 0.94-6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotypes in the control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs=-0.415, p=0.0018; GT: Rs=-0,457, p=0.0066), while for the AP group the highest levels of TPH among the TT genotype were associated with lower levels of serotonin (TT: Rs=-0.749, p<0.0001, and in the GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs=-0.738, p=0.037). Conclusions Here, a new insight in the potential role of a selected genetic factor in pancreatitis development was shown. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important points in acute pancreatitis.

show abstract

Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China

Cited by 6 publications

References 41 publications

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

Investigation of polymorphic variants of SLC6A4, TPH-1, and TPH-2 genes in cases of completed suicide

Alternative splicing in serotonergic system: Implications in neuropsychiatric disorders

TPH1 gene polymorphism rs211105 influences serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

Contact Info

Product

Resources

About