Association of polymorphisms in interleukin-8 gene with cancer risk: a meta-analysis of 22 case&amp;ndash;control studies

Zhang, Meng; Fang, Tingting; Wang, Kai; Mei, Hongbing; Lv, Zhaojie; Wang, Rui; Cai, Zhiming; Liang, Chaozhao

doi:10.2147/ott.s103159

Cited by 23 publications

(16 citation statements)

References 40 publications

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“…A n a s s o c i a t i o n wa s f o u n d r e g a r d i n g t h e polymorphism in IL16 gene (rs11556218) and the risk factors hypertension and dyslipidemia. These results corroborate the data found by Chen et al, 7 with 300 patients with ACS who showed a significant association between the homozygous variant (GG) genotype and the hypertension, diabetic and smoker individuals. In addition, the study by Wu et al, 15 with 326 Chinese patients with ACS also found an association between the GG genotype and the disease in hypertensive, diabetic, smoker, obese and dyslipemic individuals.…”

Section: Discussionsupporting

confidence: 92%

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Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Silva¹,

Araújo²,

Soares³

et al. 2019

IJCS

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Background: Acute coronary syndrome (ACS) is a cardiovascular disease caused by obstruction of coronary arteries by atheromatous plaque. Susceptibility to this disease may be related to genetic variations, such as single nucleotide polymorphisms (SNPs).Objective: In this study, we evaluated the relationship between SNPs in IL8 (rs4073; -251 A/T) and IL16 (rs11556218; T/G) genes and SCA in a Brazilian population. Materials and Methods:A sample of 200 patients with ACS and 50 non-ACS patients hospitalized at the Real Hospital Português, Recife -PE, Brazil, and 220 blood donors (donors) was used. Genotyping was carried out by polymerase chain reaction, and DNA sequencing. Statistical analyzes were performed using the Williams G, Chi-square and Kruskal Wallis tests, using the BioEstat 5.0 program, and the data with a value of p < 0.05 were considered significant. Results:In the IL8 gene, the AT genotype was the most frequent (p > 0.05) in all three groups. In the IL16 gene, genotypic distributions were different between patients with ACS and the donor group (p = 0.002), with the most frequent G allele in the second group (p = 0.0052). The IL-16 cytokine was higher in donors than in patients with ACS (p = 0.04) and the G (TG + GG) allele had higher values of this cytokine (p = 0.01). Conclusions:The results demonstrate the important role of the rs11556218 SNP in IL16 gene in SCA, evidencing that the G allele may be associated with a decreased risk of the disease.

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Section: Discussionsupporting

confidence: 92%

“…5,6 This SNP has the ability to alter the transcriptional activity of the gene, contributing to the increase of IL-8 cytokine levels. [7][8][9] IL-16 is a pleiotropic and immunoregulatory proinflammatory cytokine. 10 Elevated levels of this cytokine were detected in patients with CAD.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Silva¹,

Araújo²,

Soares³

et al. 2019

IJCS

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“…This elevation in the level of IL-8 could be attributed to increases in infl ammation responses evident in newly diagnosed HIV patient. This research fi nding is consistent with the report of Robert, et al [17] and Kolacinski, et al [18]. Whose reported the there is a signifi cant increase in the level of IL-8, in the HIV infected meningitis and in the plasma of asymptomatic HIV-l infected individuals, although not in AIDS patients.…”

Section: Discussionsupporting

confidence: 92%

Determination of Serum IL-8, CD4+ and CD8+ in Patients with Human Immunodeficiency Virus

Alhassan¹,

Yeldu²,

Kabir³

et al. 2021

J Biomed Res Environ Sci

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Background: Human Immunodeficiency Virus (HIV) is associated with a decline of immunity and progression to Acquired Immunodeficiency Syndrome (AIDS). This current study was aimed at evaluating the serum level of Interleukin-8 (IL-8), CD4+ and CD8+ T-cells counts among newly diagnosed Human Immunodeficiency Virus (HIV)-positive adults in Sokoto-Nigeria. Materials and methods: A total of 60 adults were enrolled into the study, comprising of 30 newly diagnosed HIV seropositive subjects and 30 age-and sex-matched apparently healthy controls. CD4+ and CD8+ T-cells were enumerated using flow cytometry. Serum IL-8 was analyzed using ELISA kit. Data were analyzed using SPSS 20.0 statistical package. A p-value ≤ 0.05 was considered significant in all statistical comparisons. Results: The mean of CD4+ (632.63 ± 34.83 cells/μl), CD8+ (579.98 ± 30.74 cells/μl) and CD4+/CD8+ ratio (1.10 ± 0.03 cells/μl) were significantly higher (p < 0.05) in controls compared to newly diagnosed HIV patients (160.60 ± 29.47 cells/μl, 521.10 ± 46.34cells/μl and 0.32 ± 0.52 respectively. The mean of IL-8 (6.56 ± 0.09 pg/ml) was significantly (p < 0.05) lower in controls compared to newly diagnosed patient IL-8 (6.60 ± 0.07 pg/ml). There were insignificant negative correlation between IL-8 and CD4+ (r = -0.064, p > 0.05) as well as CD8+ (r = -0.074, p > 0.05) in controls. And conversely, an insignificant positive correlation occurred between IL-8 and CD4+ (r = 0.025, p > 0.05) as well as CD8+ (r = 0.016, p > 0.05) in newly diagnosed HIV patients. Moreover, it has also shown a statistically insignificant positive correlation between IL-8 and CD4+/CD8+ ratio (r = 0.039, p > 0.05) in controls compared to newly diagnosed HIV patients where it shows a statistically insignificant negative correlation between the IL-8 and CD4+/CD8+ ratio (r = -0.076, p > 0.05). Conclusion: It could be concluded that, both CD4+, CD4+/ CD8+ ratio in newly diagnosed HIV patients are significantly decrease compared to controls (p < 0.05), while serum IL-8 was significantly increased, the serum levels of IL-8 did not correlate with CD4+ T-cells and CD8+ T-cells population, as well as CD4+/CD8+ ratio.

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“…In partial agreement with our results, a meta-analysis has explored the roles of IL-8 rs2227306 SNP and cancer risk in 22 case-control studies; they identified a significant decrease of hepatocellular carcinoma risk with IL-8 rs2227306T/C polymorphism (OR � 0.72, 95% CI � 0.56-0.91, p � 0.007 * ) [28]. is indicates the protective effect of T allele.…”

Section: Discussionsupporting

confidence: 89%

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

Ghazy

Alenzi

2021

Prostate Cancer

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The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer.

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Association of polymorphisms in interleukin-8 gene with cancer risk: a meta-analysis of 22 case–control studies

Cited by 23 publications

References 40 publications

Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Evaluation of Polymorphisms in IL8 and IL16 Genes in Patients with Acute Coronary Syndrome

Determination of Serum IL-8, CD4+ and CD8+ in Patients with Human Immunodeficiency Virus

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

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