Association of polymorphisms in MALAT1 with risk of coronary atherosclerotic heart disease in a Chinese population

Abstract

BackgroundMetastasis associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in vascular remodeling. Down-regulation of MALAT1 can inhibit the proliferation of vascular endothelial cells and vascular smooth muscle cells, reduce cardiomyocyte apoptosis and improve left ventricular function, which is closely linked to numerous pathological processes such as coronary atherosclerotic heart disease (CAD). The aim of this study was to investigate whether polymorphisms in MALAT1 were associated with the susceptibility to CAD.MethodsA total of 508 CAD patients and 562 age-, gender-, and ethnicity-matched controls were enrolled in this study. Four polymorphisms in MALAT1 (i.e., rs11227209, rs619586, rs664589, and rs3200401) were genotyped using a TaqMan allelic discrimination assay.ResultsThe rs619586 AG/GG genotypes and G allele were associated with a reduced risk of CAD (AG/GG vs. AA: adjusted OR = 0.66, 95% CI: 0.48–0.91; G vs. A: adjusted OR = 0.68, 95% CI: 0.51–0.90). Stratification analyses showed that CAD patients with rs11227209 CG/GG, rs619586 AG/GG, and rs3200401 CT/TT genotypes exhibited lower levels of TCH (P = 0.02, 0.04, and 0.02, respectively). Moreover, CGCC haplotype was associated with a decreased risk of CAD (OR = 0.28, 95% CI: 0.16–0.48). Multivariate logistic regression analysis identified some independent risk factors for CAD, including rs619586 and rs664589. Subsequent combined analysis showed that the combined genotypes of rs619586AG/GG and rs664589CC were associated with a reduced risk of CAD (OR = 0.29; 95%CI, 0.16–0.53).ConclusionsThese findings indicate that rs619586AG/GG genotypes in MALAT1 may protect against the occurrence of CAD.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0728-2) contains supplementary material, which is available to authorized users.

The role of lncRNA MALAT1 in cardiovascular disease

“…38 The SNPs in MALAT1 were associated with CVD risk in a Chinese population. 39 MALAT1 was also found up-regulated in patients with unstable angina and high-fat food fed ApoE −/− mice, indicating MALAT1 participated in development of atherosclerosis. 35,40 Knockdown of MALAT1 caused increased plaque size and infiltration of inflammatory CD45 + cells partly via regulation of miR-503.…”

“…Atherosclerosis is the main cause of CVD . The SNPs in MALAT1 were associated with CVD risk in a Chinese population . MALAT1 was also found up‐regulated in patients with unstable angina and high‐fat food fed ApoE −/− mice, indicating MALAT1 participated in development of atherosclerosis .…”

Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women

“…In recent years, increasing evidence has indicated that lncRNAs play 24 or coronary atherosclerotic heart disease. 25 We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with increased endometrial cancer risk.…”

Correlation Between Single Nucleotide Polymorphisms of the rs664589 Locus in the Long-Chain Noncoding RNA Lung Adenocarcinoma Metastasis-Associated Gene 1, Hypertension, and Its Mechanism

“…For example, Wu et al (2019) showed that SNPs of the MALAT1 rs664589 polymorphism inhibit the binding of miR-194-5p, leading to the increased risk of colorectal cancer. Wang et al (2018) found that rs619586 locus of the MALAT1 is associated with the risk of coronary atherosclerotic heart disease. In this study, we found that the SBP and DBP of the G allele carriers of the rs664589 locus of the MALAT1 gene were significantly higher than those of the C allele carriers, and the G allele gene was susceptible for hypertension.…”