Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection

Segat, Ludovica; Vasconcelos, Luydson Richardson Silva; Melo, Francisco Vicente Sales; Silva, Bruna Santos; Arraes, Luiz Cláudio; Moura, Patrícia; Crovella, Sérgio

doi:10.1016/j.clim.2007.04.006

Cited by 27 publications

(43 citation statements)

References 28 publications

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“…A limited number of studies have examined the role of MBL in HCV pathogenesis (4,5,(17)(18)(19)(20)(21). In the studies conducted in Japan, relationships were found between the codon 54 mutation and low MBL levels, disease progression, and treatment response.…”

Section: Discussionmentioning

confidence: 99%

Effects of mannose-binding lectin and mannose-binding lectin polymorphisms on treatment response in patients with chronic hepatitis C

Kömür

İnal²,

Ulu³

et al. 2015

Turk J Gastroenterol

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Background/Aims: The natural course and clinical outcome of hepatitis C virus (HCV) infection is related to the interaction between HCV and the immune response of the host. Only a limited number of studies have investigated the role of mannose-binding lectin (MBL) levels in HCV infection. The aim of the present study was to explore the relationship between MBL levels and gene polymorphisms on treatment response in patients with chronic hepatitis C (CHC). Materials and Methods: Serum MBL levels from 50 CHC patients who completed treatment at least 24 weeks before the present study and 75 healthy HCV-negative controls were measured. In addition, the presence of codon 54 mutations was investigated. Correlational analyses were performed to determine relationships between MBL levels and treatment response. Results: In patients, mean serum MBL levels were lower and the rate of codon 54 mutations was higher. However, these differences were not statically significant. In both patients and controls, serum MBL levels were significantly lower in individuals with codon 54 mutations. Moreover, serum MBL levels and the rate of the codon 54 mutation were similar in patients regardless of treatment response. Conclusion: Our findings suggest that low MBL levels do not increase the susceptibility for HCV infection. Furthermore, MBL levels were not found to have a significant effect on the course of the disease or treatment response.

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Section: Discussionmentioning

confidence: 99%

Effects of mannose-binding lectin and mannose-binding lectin polymorphisms on treatment response in patients with chronic hepatitis C

Kömür

İnal²,

Ulu³

et al. 2015

Turk J Gastroenterol

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show abstract

“…The MBL2 polymorphism has been associated with HCV infection susceptibility in some clinical investigations [15,16]. By contrast, the association of MBL2 variant alleles with fibrosis has shown conflicting results.…”

Section: Introductionmentioning

confidence: 95%

Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population

Halla¹,

Carmo²,

Vasconcelos³

et al. 2010

Human Immunology

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“…The frequency of MBL levels <100 ng/mL in the control group was, however, very low (2%) compared to the genotypic frequency of MBL polymorphisms (6%) reported for a group of individuals with the same ethnic background (14). This may be explained by the fact that the monoclonal antibody used in the present study recognized both high-and low-molecular weight variants of MBL, making the amount of MBL in circulation less dependent on the presence of structural variant alleles detected by genotyping (11,14).…”

Section: Discussionmentioning

confidence: 90%

“…The immunoreactive ELISA utilized in the present study suggests a new approach to the determination of high-and low-molecular weight forms of circulating MBL with a monoclonal antibody, while the commercial kits for MBL determination recognize only the high-molecular weight forms. Since our population has shown a high frequency of heterozygous individuals (30%) for MBL (14), the monoclonal ELISA employed had the advantage that it could detect either low-or high-molecular weight forms of MBL.…”

Section: Discussionmentioning

confidence: 99%

High levels of serum mannose-binding lectin are associated with the severity of clinical signs of leptospirosis

Miranda

Vasconcelos

Coelho

et al. 2009

Braz J Med Biol Res

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The clinical heterogeneity observed in leptospirosis may be associated with host factors or bacteria virulence. Human serum mannose-binding lectin (MBL) recognizes many pathogens, and low levels of this lectin are associated with susceptibility to infection. MBL is also implicated in the modulation of the inflammatory process. We determined the levels of serum MBL during leptospirosis infection. A double-antibody sandwich ELISA was used to detect the immunoreactive serum MBL. The ELISA plates were coated with monoclonal antibody to MBL and bound MBL or recombinant human MBL were detected by rabbit antihuman MBL serum. HRPO-conjugated goat anti-rabbit antibody was used for detection of the reaction. Two groups of patients seen at referral hospitals in Recife, PE, Brazil, were divided according to the year of infection, 2001 (N = 61) or 2002 (N = 57) and compared in terms of disease severity and levels of serum MBL. A group of healthy volunteers (N = 97) matched by age, gender, and ethnic background was used as control. Patients infected in 2001 had more severe outcomes than those infected in 2002, including jaundice, hemorrhage, respiratory alteration, and renal complication (P = 0.0009; chi-square test). The frequency of patients producing serum MBL >1000 ng/mL was higher in the 2001 group than in the 2002 and control groups (P < 0.01), suggesting an association of MBL level with disease severity. The involvement of MBL and genetic variation of the MBL2 gene should be further evaluated to establish the role of this lectin in the pathogenesis of leptospirosis.

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Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection

Cited by 27 publications

References 28 publications

Effects of mannose-binding lectin and mannose-binding lectin polymorphisms on treatment response in patients with chronic hepatitis C

Effects of mannose-binding lectin and mannose-binding lectin polymorphisms on treatment response in patients with chronic hepatitis C

Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population

High levels of serum mannose-binding lectin are associated with the severity of clinical signs of leptospirosis

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