“…4,27 Two functional missense SNPs (Single Nucleotide Polymorphism) in the coding sequence of TLR4 gene are rs4986790 (A + 896G, Asp299Gly) and rs4986791 (C + 1196T, Thr399Ile), with linkage disequilibrium, modify the extracellular domain of the corresponding protein and lead to a different LPS responsiveness. 28 The recent meta-analysis studies have suggested the effects of TLR4 polymorphisms on susceptibility to various diseases such as Open Angle Glaucoma (rs1927911, rs2149356, rs4986791, rs7037117, and rs10759930), 29 cancers (rs4986790 and rs4986791), 30,31 Pneumonia (rs4986790), 32 Asthma (rs4986791), 33 Crohn's disease (rs4986791), 34 and Atopic Dermatitis (rs4986790). 35 IL-8 as an important chemotactic cytokines has a high level of productions in the nAMD patient's PBMCs and RPE cells.…”