Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese

Abstract

Aim. Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. Material and Methods. PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing. Results. Seven SNPs were significantly associated with PsV: rs805303 ( P = 0.012 , OR = 0.85 ), rs3177928 ( P = 1.37 × 10 − 15 , OR = 2.51 ), and rs2247056 ( P = 3.73 × 10 − 4 , OR = 0.67 ) located in the HLA gene region; rs1047781 ( P = 0.012 , OR = 1.18 ), rs281379 ( P = 0.014 , OR = 1.71 ), and rs492602 ( P = 0.005 , OR = 1.86 ) located in the FUT2 region; and rs2303138 ( P = 0.014 , OR = 1.18 ) located in the LNPEP region. After stratified analysis, rs805303 ( P = 0.017 , OR = 0.74 ) and rs2303138 ( P = 0.041 , OR = 1.30 ) were associated with PsVs when HLA-C ∗ 06 : 02 was positive, and rs805303 ( P = 5.62 × 10 − 5 , OR = 0.68 ), rs3177928 ( P = 0.003 , OR = 1.75 ), rs281379 ( P = 0.034 , OR = 1.96 ), and rs492602 ( P = 0.025 , OR = 2.04 ) were associated with PsVs when HLA-C ∗ 06 : 02 was negative. Conclusion. PsV and metabolic syndrome may have overlapped susceptible genes in Chinese Han population.

A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis

“…1 . Significant genes on the Manhattan plot represent each position on chromosomes 6, 10, 15, and 18 . In the genetic additive model analysis (major homo-genotype versus hetero-genotype versus minor homo-genotype), the most significant genes associated with MetS in psoriasis in GWAS analysis were the FERM domain containing 4A ( FRMD4A ), G protein-coupled receptor 116 ( GPR116 ), and mitogen-activated protein kinase 4 ( MAPK4 ) ( p <0.0001, respectively).…”

“…Recent studies also report genetic associations between psoriasis and MetS. Liu et al 18 examined 18 SNPs previously reported to be significantly associated with MetS, and found seven which were significantly associated with psoriasis in the Han Chinese population. Abdel Hay and Rashed 19 suggested that the leptin gene ( LEP G-2548A) polymorphism could be a predictor for psoriasis and MetS among a sample of the Egyptian population, by showing that patients carrying the LEP G-2548C allele had a significantly higher prevalence of psoriasis and MetS than non-carriers.…”

A Bibliometric Analysis of Global Research Trends in Psoriasis and Metabolic Syndrome

“…There could be shared susceptibility genes for psoriasis vulgaris and MetS among the Chinese Han population. 5 Nevertheless, several studies have shown no genetic links between the two diseases. 45–48 …”

“…There could be shared susceptibility genes for psoriasis vulgaris and MetS among the Chinese Han population. 5 Nevertheless, several studies have shown no genetic links between the two diseases. [45][46][47][48] Clinical, Cosmetic and Investigational Dermatology 2024:17 https://doi.org/10.2147/CCID.S446966…”

“…In the Chinese Han population, psoriasis vulgaris and MetS might share overlapping susceptible genes. 5 The correlation between psoriasis and MetS is of significant clinical importance. Certain conventional systemic treatments should be administered with caution in psoriatic individuals with MetS due to their potential adverse effects on coexisting metabolic conditions, especially with prolonged use.…”