Association of polymorphisms of the oestrogen receptoralpha gene with the age of menarche

Stavrou, Ioanna; Zois, Christos; Ioannidis, John P. A.; Tsatsoulis, Agathocles

doi:10.1093/humrep/17.4.1101

Cited by 111 publications

(86 citation statements)

References 27 publications

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“…Age at menarche is also influenced by genetic factors. XbaI polymorphism of estrogen receptor alpha gene was proved to be associated with combined predisposition to AIS occurrence, curve severity, and late menarche, which strongly mirrors the findings of our study [18][19][20].…”

Section: Discussionsupporting

confidence: 90%

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

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Age at menarche is closely related to scoliosis progression during adolescence. Current data concerning the timing of menarche between scoliotic and non-scoliotic girls in the literature are conflicting, with inconclusive results. The aim of this study was to investigate the distribution difference of age at menarche for adolescent idiopathic scoliosis (AIS) girls and normal control population and to subsequently elucidate the menarche age difference through literature reviewing. Moreover, menarche age of AIS girls with Cobb angle \40°, 40-60°, [60°were compared to estimate its association with curve severity. Menstrual status data were available for 6,376 healthy female adolescents and 2,196 AIS girls. We notice that less than 10% of healthy Chinese girls experienced onset of menses before 11.38 years, and approximately 90% of healthy Chinese girls were menstruating by 13.88 years, with a median age of 12.63 years. As for AIS girls, less than 10% started to menstruate before 11.27 years, and approximately 90% were menstruating by 14.38 years, with a median age of 12.83 years. Average menarche age in AIS (12.83 ± 1.22 years) was significantly later than that of normal control girls (12.63 ± 0.98 years) (p \ 0.001). Age at menarche for AIS affected girls was significantly greater than that of normal control girls at 75%, 90% of whom had attained menarche (p = 0.001, p \ 0.001). Proportion of girls starting to menstruate after 14 years was significantly higher in AIS population compared with normal controls (16.3 vs. 8.1%, p \ 0.001). In addition, AIS girls with Cobb angle [60°experienced onset of menses at an average age of 13.25 years, which was significantly later than AIS girls with Cobb angle \40°(12.81 years, p \ 0.05) and marginally significantly later than AIS girls with Cobb angle between 40 and 60°(12.86 years, p = 0.053). In conclusion, a tendency of delayed onset of menarche was observed in Chinese idiopathic scoliotic girls in this large sample study, especially for girls with Cobb angle [60°, which is supported by multiple previously established positive linkages on AIS etiology studies. Accordingly it is believed that late menarche may contribute importantly to abnormal pubertal growth and subsequently modulate curve behavior in AIS.

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Section: Discussionsupporting

confidence: 90%

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

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“…38 Therefore, the ER-a gene has been considered as a candidate gene for the onset of menarche, which was substantiated in several studies. 39,40 Another possible pleiotropic gene is beta 3-AR gene. Mutations in beta 3-AR gene may result in a diminished lipolytic response in adipose tissue and lower resting metabolic rate.…”

Section: Discussionmentioning

confidence: 99%

Genetic and environmental correlations between obesity phenotypes and age at menarche

Wang

Zhao

et al. 2006

Int J Obes

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Objective: To assess the extent that the genetic and environmental factors contribute to the phenotypic correlations between obesity traits and age at menarche (AAM), and also to examine the influence of AAM on obesity in both pre-and postmenopausal women. Methods: Five hundred and twelve pedigrees with 2667 Caucasian female subjects from two to four generations were recruited. Fat mass and lean mass (both in kg) were measured by dual-energy X-ray absorptiometry scanner. Body mass index (BMI) (kg/m 2 ) was calculated. We performed bivariate quantitative genetic analyses in the total sample containing 2667 Caucasian women. We also selected 206 unrelated premenopausal women and 140 unrelated postmenopausal women from the total sample, and computed the respective phenotypic correlation between obesity and AAM in these two subgroups. Results: For fat mass, lean mass and BMI, we detected their significant negative genetic correlations with AAM after adjustment for significant covariates, which were À0.3170 (Po0.001), À0.1721 (Po0.05) and À0.3665 (Po0.001), respectively. However, their environmental correlations with AAM were all nonsignificant (P40.05), ranging from À0.0016 to 0.0192. In the premenopausal subgroup, significant associations were observed between fat mass and AAM (r ¼ À0.231, Po0.01) as well as between BMI and AAM (r ¼ À0.257, Po0.01). In the postmenopausal subgroup, no such associations were observed. Conclusion: Our results for the first time suggested that significant phenotypic association between obesity phenotypes and AAM is mainly attributable to shared genetic rather than environmental factors, and AAM may have stronger effects on obesity phenotypes in pre-than in postmenopausal women.

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“…Specifically, correlative epidemiological studies have identified the early onset of regular ovarian cycles after menarche as a risk factor (Apter & Vihko, 1983). Moreover, two different polymorphisms of the estrogen receptor a gene, which are associated with reduced breast cancer risk, were also associated with a relative delay in menarcheal age in Greek adolescent girls (Stavrou, Zois, Ioannidis, & Tsatsoulis, 2002). From literature on adult menstrual cycle function, we know that the timing and incidence of pregnancy, lactation, and menopause all confer risk or protection from breast cancer (Hilakivi-Clarke et al, 2002;Kelsey, 1989;Pike et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden

Hermes

McClintock

2008

Developmental Psychobiology

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In this study of Norway rats, we hypothesized that lifelong psychosocial experiences, social isolation or group living, trigger different developmental trajectories in the ovarian system, contributing to predisease pathways for spontaneous mammary tumors. Epidemiological studies indicate that early puberty and delayed menopause are risk factors for breast cancer. To that end, we took a cross-sectional, prospective approach and examined the ovarian system at two developmental points, young adulthood and middle age. We assessed ovarian function at both points, as well as mammary gland development at puberty and mammary tumor burden in middle age. Social isolation dissociated two components of puberty; it accelerated maturation of ovarian function while it simultaneously delayed mammary tissue development thereby increasing the exposure of developing breast parenchyma to high levels of estrogen. By mid-life, socially isolated rats had greater tumor burden despite having entered estropause prematurely, demonstrating that isolation did not increase tumorigenesis by prolonging ovarian function. These findings are discussed in the context of facultative lifespan strategies for rats born at different times of year and those living in isolation or in a large burrow community. ß 2008 Wiley Periodicals, Inc. Dev Psychobiol 50: 353-360, 2008.

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Association of polymorphisms of the oestrogen receptoralpha gene with the age of menarche

Abstract: We document that the XbaI polymorphism, and possibly PvuII, may be genetic determinants of the age of menarche.

Cited by 111 publications

References 27 publications

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Genetic and environmental correlations between obesity phenotypes and age at menarche

Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: Implications for mammary tumor burden

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