1995
DOI: 10.1159/000168856
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Association of Post-Renal Transplant Erythrocytosis and Microalbuminuna: Response to Angiotensin-Converting Enzyme Inhibition

Abstract: Angiotensin-converting enzyme (ACE) inhibitor therapy has recently been shown to be effective in the treatment of post-renal transplant erythrocytosis (PTE). In an attempt to assess the effect of drug treatment on serum erythropoietin level, glomerular filtration rate, and urinary protein excretion, we prospectively evaluated 8 consecutive cadaveric renal transplant recipients with PTE treated with ACE inhibitor therapy for 3 months. In response to ACE inhibition, the mean hematocrit (HCT) value decreased from… Show more

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Cited by 13 publications
(5 citation statements)
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“…A total of 61 studies underwent full-length article review; 22 were excluded, as they did not include controls or report the outcome of interest. A total of 39 observational studies [4,6,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47], including 7,099 patients, finally met our inclusion criteria and were included in the meta-analysis. Figure 1 outlines our search methodology and selection process; the baseline characteristics of the included studies are summarized in Table 1.…”
Section: Resultsmentioning
confidence: 99%
“…A total of 61 studies underwent full-length article review; 22 were excluded, as they did not include controls or report the outcome of interest. A total of 39 observational studies [4,6,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47], including 7,099 patients, finally met our inclusion criteria and were included in the meta-analysis. Figure 1 outlines our search methodology and selection process; the baseline characteristics of the included studies are summarized in Table 1.…”
Section: Resultsmentioning
confidence: 99%
“…The ability of ACE inhibitors to reduce the elevated Hct has been demonstrated in patients with high or normal EPO levels, although EPO levels may or may not change [9,14,16,17,27]. In addition, ACE inhibitors are effective even when EPO levels are nondetectable, possibly by inhibiting proliferation of burst and colony-forming erythroid units which have an increased sensitivity to the effects of EPO in this patient population [12].…”
Section: Discussionmentioning
confidence: 99%
“…The failure to detect a change may have been due to small sample size and the large variability of EPO levels. ACE inhibitor therapy has also been reported to induce reversible anemia in renal transplant patients with or without posttransplant erythrocytosis [10,16].…”
Section: Discussionmentioning
confidence: 99%
“…There are a number of small RCTs of fair quality and case series demonstrating the use of ACE‐Is or ARBs to reduce hematocrit by an absolute value of between 4% and 15% (785–797). Given the small sample sizes and the lack of data on critical clinical outcomes, there is only a low level of evidence (see Evidence Profile and accompanying evidence in Supporting Tables 56–58).…”
Section: Rationalementioning
confidence: 99%