2016
DOI: 10.7717/peerj.2022
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Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus: a proteomic analysis by mass spectrometry

Abstract: Aim/hypothesis: The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in two different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic retinopathy (NPDR) and (2) with proliferative diabetic retinopathy (PDR). Type-2 diabetes mellitus without diabetic retinopathy (XDR) was designated as control.Method: In this study, 45 saliva samples were collected (15 samples from XDR control group, 15 samples from… Show more

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Cited by 27 publications
(17 citation statements)
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“…There is a case reported of a mutation in ELANE gene as the cause of chronic parvovirosis in a woman [55]. The activation of complement C3 supports local inflammatory responses against pathogens and initiates the humoral immune response, playing a central role in the activation of the complement system [56]. Increased C3 expression has also been reported in dogs with canine babesiosis [57].…”
Section: Discussionmentioning
confidence: 99%
“…There is a case reported of a mutation in ELANE gene as the cause of chronic parvovirosis in a woman [55]. The activation of complement C3 supports local inflammatory responses against pathogens and initiates the humoral immune response, playing a central role in the activation of the complement system [56]. Increased C3 expression has also been reported in dogs with canine babesiosis [57].…”
Section: Discussionmentioning
confidence: 99%
“…Natal origin of S. officinalis collected near the Strait of Gibraltar in the NEAO was predicted using direct maximum-likelihood estimates (MLE) of stock composition [ 17 , 18 ]. Mixed-stock analysis was run under bootstrap mode to obtain standard deviations around estimated proportions (error terms) with 500 simulations [ 19 ].…”
Section: Methodsmentioning
confidence: 99%
“…Future studies using nanoemulsifying drug delivery systems might help with increased bioavailability, thereby further assisting in PLE-mediated disease amelioration. Nonetheless, a recent discovery based proteomics study reported that SPARC-like protein 1 precursor (SPARCL1) levels were elevated in non-proliferative diabetic retinopathy subjects ( Chee et al 2016 ). In our study, the PLE-treated patients showed down-regulation of SPARCL1 ( Table 3 ).…”
Section: Resultsmentioning
confidence: 99%