Association of prediabetes, defined by fasting glucose, HbA1c only, or combined criteria, with the risk of cardiovascular disease in Koreans

Kim, Hong‐Kyu; Lee, Jung Bok; Kim, Seon Ha; Jo, Min‐Woo; Kim, Eun Hee; Hwang, Jenie Yoonoo; Bae, Sung Jin; Jung, Chang Hee; Lee, Woo Je; Park, Joong‐Yeol; Park, Gyung‐Min; Kim, Young‐Hak; Choe, Jaewon

doi:10.1111/1753-0407.12343

Cited by 16 publications

(18 citation statements)

References 48 publications

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“…However, there is evidence to suggest that hyperinsulinism is the first metabolic abnormality seen in obese pediatric patients, and impaired fasting glucose occurs at a much later stage in the progression toward type 2 diabetes mellitus . Further, in adults, HbA 1c and FBG are also differentially associated with cardiovascular risk profiles, with HbA 1c being more strongly associated with increased risk of cardiovascular events than FBG . While the findings from the current study cannot corroborate the previous findings in adults, both the adiposity (HbA 1c ) and vascular (FBG) factors were significantly worse for overweight‐obese children compared with normal‐weight children.…”

Section: Discussioncontrasting

confidence: 87%

“…Findings in adults suggest that HbA 1c and FBG have different patterns of association with cardiovascular risk profiles . For example, HbA 1c is more strongly associated with increased risk of cardiovascular events than FBG . We could identify no studies that explored whether HbA 1c and FBG are differentially associated with cardiovascular risk profiles in children.…”

Section: Introductionmentioning

confidence: 97%

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Cardiometabolic Risk Variables in Preadolescent Children: A Factor Analysis

Stoner

Weatherall

Skidmore

et al. 2017

JAHA

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BackgroundAtherosclerosis begins during preadolescence and is occurring at an accelerated rate. This acceleration has been linked to poor lifestyle behaviors and subsequent cardiometabolic complications. Although the clustering of cardiometabolic risk factors has been recognized for over 2 decades, previous studies in children have predominantly examined the relationships between atherosclerosis and individual cardiometabolic risk factors or have grouped together preadolescent and adolescent children. Further, no known studies have included glycated hemoglobin or central hemodynamic measures such as central systolic blood pressure and augmentation index.Methods and ResultsPrincipal component analysis was performed on a cross‐sectional sample of 392 children (aged 9.5 years, 50% girls) from 3 representative sample sites across New Zealand. Four factors explained 60% of the variance in the measured variables. In order of variance explained, the factors were: blood pressure (central systolic blood pressure and peripheral systolic and diastolic blood pressure), adiposity (waist circumference, body mass index, and glycated hemoglobin), lipids (total cholesterol, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol), and vascular (augmentation index, heart rate, and fasting blood glucose).ConclusionsIn accordance with previous findings in adults and adolescents, one common factor is unlikely to define cardiometabolic health in preadolescent children. Each of the factors, except vascular, which was predominantly explained by augmentation index, are in agreement with previous findings in adolescents. An additional novel finding was that glycated hemoglobin and fasting blood glucose loaded onto different factors, supporting previous work suggesting that fasting blood glucose indicates short‐term glycemic control, whereas glycated hemoglobin reflects chronic glycemic control.Clinical Trial Registration URL: www.anzctr.org.au/. ID: ACTRN12614000433606.

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Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Cardiometabolic Risk Variables in Preadolescent Children: A Factor Analysis

Stoner

Weatherall

Skidmore

et al. 2017

JAHA

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“…46,47 Further, in adults, HbA 1c and FBG are also differentially associated with cardiovascular risk profiles, 18 with HbA 1c being more strongly associated with increased risk of cardiovascular events than FBG. 19,20 While the findings from the current study cannot corroborate the previous findings in adults, both the adiposity (HbA 1c ) and vascular (FBG) factors were significantly worse for overweight-obese children compared with normal-weight children.…”

Section: Comparison With Other Studiescontrasting

confidence: 99%

“…18 For example, HbA 1c is more strongly associated with increased risk of cardiovascular events than FBG. 19,20 We could identify no studies that explored whether HbA 1c and FBG are differentially associated with cardiovascular risk profiles in children. Although past research in this area has included peripheral blood pressure (BP) when examining cardiometabolic risk clustering in children, [10][11][12] this may not accurately reflect the effects of peak arterial BP on centrally located organs.…”

mentioning

confidence: 99%

Cardio-metabolic Risk Variables In Pre-adolescent Children - A Factor Analysis

Stoner

Weatherall

Castro

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Background--Atherosclerosis begins during preadolescence and is occurring at an accelerated rate. This acceleration has been linked to poor lifestyle behaviors and subsequent cardiometabolic complications. Although the clustering of cardiometabolic risk factors has been recognized for over 2 decades, previous studies in children have predominantly examined the relationships between atherosclerosis and individual cardiometabolic risk factors or have grouped together preadolescent and adolescent children. Further, no known studies have included glycated hemoglobin or central hemodynamic measures such as central systolic blood pressure and augmentation index.

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“…Other studies that also analyzed the association between different measurements of glycemia using C-IMT [1, 13, 30, 31] and found divergent results. In our study, the independent association of the HbA1C and fasting glucose with the mean and maximum C-IMT remains after the adjustment for age, sex, drug treatment and others cofounding cardiovascular factors, including the association between the above-mentioned parameters and glucose levels 2 h after a meal.…”

Section: Discussionmentioning

confidence: 99%

Association between markers of glycemia and carotid intima-media thickness: the MARK study

Gómez‐Marcos

Gómez‐Sánchez²,

Patino-Alonso

et al. 2016

BMC Cardiovasc Disord

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BackgroundCarotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients.MethodsThis study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose, 104 subjects classified as prediabetes and 92 with type 2 diabetes mellitus. Carotid ultrasound was used to measure C-IMT and the presence of plaques. Fasting plasma glucose (mg/dl) and glycated hemoglobin (%) (HbA1c) were measured using standard enzymatic automated methods. Postprandial glucose (mg/dl) was self-measured by patients at home 2 h after meals (breakfast, lunch and dinner) for 1 day.ResultsThe C-IMT shows a positive correlation with fasting plasma glucose, postprandial glucose and HbA1c. Multiple linear regression analysis showed a positive association between HbA1c and C-IMT, with a 0.016 mm and 0.019 mm increase in mean and maximum C-IMT per 1 % increase in HbA1c. In addition, an association between fasting plasma glucose and C-IMT was found with an increase of 0.004 and 0.005 mm in mean and maximum C-IMT per 10 mg/dl in fasting plasma glucose. We also observed a graded association between fasting plasma glucose, postprandial glucose and HbA1c and the presence of carotid target organ damage (TOD), with an odds ratio of 1.013, 1.010 and 1.425, respectively.ConclusionThe results of this study suggest that the fasting plasma glucose and HbA1c, but not postprandial glucose, are associated with C-IMT media and maximum. The patients who present with a metabolic glucose alteration have more risk of developing carotid TOD.Trial registrationClinicalTrials.gov; Identifier: NCT01428934.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0380-6) contains supplementary material, which is available to authorized users.

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Association of prediabetes, defined by fasting glucose, HbA1c only, or combined criteria, with the risk of cardiovascular disease in Koreans

Abstract: Adding an HbA1c criterion when defining prediabetes in Koreans can help identify individuals with an increased risk of CVD.

Cited by 16 publications

References 48 publications

Cardiometabolic Risk Variables in Preadolescent Children: A Factor Analysis

Cardiometabolic Risk Variables in Preadolescent Children: A Factor Analysis

Cardio-metabolic Risk Variables In Pre-adolescent Children - A Factor Analysis

Association between markers of glycemia and carotid intima-media thickness: the MARK study

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