Association of Pregnancy with Stone Formation among Women in the United States: A NHANES Analysis 2007 to 2012

Reinstatler, Lael; Khaleel, Sari; Pais, Vernon M.

doi:10.1016/j.juro.2017.02.3233

Cited by 29 publications

(17 citation statements)

References 11 publications

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“…However, as shown in Fig. , young women (aged 20–35 years) had a higher incidence compared to men, which is consistent with the high UL risk around pregnancy .…”

Section: Discussionsupporting

confidence: 78%

Familial risks in urolithiasis in the population of Sweden

Hemminki

Försti

et al. 2018

BJU International

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“…However, as shown in Fig. , young women (aged 20–35 years) had a higher incidence compared to men, which is consistent with the high UL risk around pregnancy .…”

Section: Discussionsupporting

confidence: 78%

Familial risks in urolithiasis in the population of Sweden

Hemminki

Försti

et al. 2018

BJU International

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“…This difference may be more attributable to differences in endogenous oxalate production than to dietary intake. As reported recently, analysis of the 2007–2012 NHANES data indicated strong association of kidney stones in women younger than 50 years with prior pregnancies 23 . Women of reproductive age who had been pregnant had more than twice the odds of developing stones, compared with women who had never been pregnant.…”

Section: Discussionmentioning

confidence: 60%

A Twin Study of Genetic Influences on Nephrolithiasis in Women and Men

Goldfarb

Avery

Beara-Lasić

et al. 2019

Kidney International Reports

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Background Nephrolithiasis is a complex phenotype influenced by both genetic and environmental factors. Previously we found a genetic component to stone disease using a sample of male twin pairs. We now report on the genetic contribution to stones in a sample of female and male twin pairs. Methods We conducted a classic twin study of kidney stones using the Washington State Twin Registry. Data were collected by questionnaire to obtain self-reported history of kidney stones. Univariate structural equation modeling was used to determine the relative contributions of additive genetics, common environment, and unique environment. Results There were 7053 same-sex pairs with kidney stone data. The mean age of the sample was 39 years, similar in women and men. The prevalence of stones was 4.9% of women and 6.2% of men. We found significant contributions from genetics and the unique environment ( P < 0.05 for both) for the risk for stone disease in women and men. There was no significant contribution of the common environment for either sex. After adjusting for age, heritability was 46% (95% confidence interval 0.36–0.56) in women and 57% (0.46–0.68) in men, which was significantly different ( P < 0.05). Conclusions Nephrolithiasis in women has a heritable component less than that we again demonstrate in men. This finding may in part explain why more stone formers are men than women. Women twins demonstrated a greater effect of the unique environment on stone prevalence. The specific environmental risk factors that account for this effect are not currently known.

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“…Obesity is a an established risk factor for kidney stones 12 that may increase the risk of recurrence via hypercalciuria 13 or via insulin resistance with lower urine pH and hypocitraturia. 14 Pregnancy has recently been identified as a risk factor for kidney stones, 15 possibly due to hypercalciuria during pregnancy. 16 We also added more granular radiographic predictors compared to the original ROKS model.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Symptomatic Kidney Stone Recurrence After the First and Subsequent Episodes

Vaughan

Enders

Lieske

et al. 2019

Mayo Clinic Proceedings

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Objective: To predict symptomatic recurrence among community stone formers with one or more prior stone episode. Patients and Methods: A random sample of incident symptomatic kidney stone formers in Olmsted County, Minnesota were followed for all symptomatic stone episodes resulting in clinical care from 1/1/1984 to 1/31/2017. Clinical and radiographic characteristics at each stone episode predictive of subsequent episodes were identified. Results: There were 3,364 incident kidney stone formers with 4,951 episodes. The stone recurrence rates per 100 person-years were 3.4 (95% CI, 3.2-3.7) after the first episode, 7.1 (95% CI, 6.4-7.9) after the second episode, 12.1 (95% CI, 10.3-13.9) after the third episode, and 17.6 (95% CI, 15.1-20.0) after the fourth or higher episode (P<.001 for trend). A parsimonious model identified the following independent risk factors for recurrence: younger age, male sex, higher body mass index, family history of stones, pregnancy, incident asymptomatic stone on imaging before the first episode; suspected stone episode before the first episode; history of a brushite, struvite, or uric acid stone; no history of calcium oxalate monohydrate stones, kidney pelvic or

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Association of Pregnancy with Stone Formation among Women in the United States: A NHANES Analysis 2007 to 2012

Cited by 29 publications

References 11 publications

Familial risks in urolithiasis in the population of Sweden

Familial risks in urolithiasis in the population of Sweden

A Twin Study of Genetic Influences on Nephrolithiasis in Women and Men

Predictors of Symptomatic Kidney Stone Recurrence After the First and Subsequent Episodes

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