Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function

Howe, Caitlin G.; Eckel, Sandrah P.; Habre, Rima; Girguis, Mariam S.; Gao, Lu; Lurmann, Frederick; Gilliland, Frank D.; Breton, Carrie V.

doi:10.1001/jamanetworkopen.2018.2172

Cited by 63 publications

(57 citation statements)

References 36 publications

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“…Current concentrations of PM 2.5 continue to adversely affect health, increasing risk of cardiovascular and respiratory disease, as well as neurological disorders [2,3]. Furthermore, living near heavy traffic has substantial adverse effects on lung function development, chronic bronchitis, decreased lung function, heart disease, atherosclerosis, high blood pressure, and birth outcomes [4][5][6][7][8]. Southern California (CA) faces some of the country's worst air pollution, the nation's largest port complex, large industrial polluters, and significant traffic pollution.…”

Section: Introductionmentioning

confidence: 99%

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Johnston

Juarez

Navarro³

et al. 2019

IJERPH

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Air pollution in Southern California does not impact all communities equally; communities of color are disproportionately burdened by poor air quality and more likely to live near industrial facilities and freeways. Government regulatory monitors do not have the spatial resolution to provide air quality information at the neighborhood or personal scale. We describe the A Day in the Life program, an approach to participatory air monitoring that engages youth in collecting data that they can then analyze and use to take action. Academics partnered with Los Angeles-based youth environmental justice organizations to combine personal air monitoring, participatory science, and digital storytelling to build capacity to address local air quality issues. Eighteen youth participants from four different neighborhoods wore portable personal PM2.5 (fine particles <2.5 µm in diameter) monitors for a day in each of their respective communities, documenting and mapping their exposure to PM2.5 during their daily routine. Air monitoring was coupled with photography and videos to document what they experienced over the course of their day. The PM2.5 exposure during the day for participants averaged 10.7 µg/m3, although the range stretched from <1 to 180 µg/m3. One-third of all measurements were taken <300 m from a freeway. Overall, we demonstrate a method to increase local youth-centered understanding of personal exposures, pollution sources, and vulnerability to air quality.

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Section: Introductionmentioning

confidence: 99%

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Johnston

Juarez

Navarro³

et al. 2019

IJERPH

View full text Add to dashboard Cite

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“…Based on the consideration that in the Mount Etna volcanic area residents' exposure to increased tungsten is a chronic, life-long condition starting in prenatal life because the fetus and the newborn are exposed by transplacental and breast-feeding routes (Wide et al 1986, Pitt et al 1991, we hypothesized that early exposure to increased tungsten might predispose individuals to TC risk later in life. Stem/ progenitor cells, in fact, may be more susceptible to the detrimental effect of increased toxicant and transmit the damage to their differentiated progeny, as previously observed in other human and animal models (Waalkes et al 2008, McInturf et al 2011, Xu et al 2013, Kopras et al 2014, Howe et al 2018.…”

Section: Introductionmentioning

confidence: 60%

Effect of low-dose tungsten on human thyroid stem/precursor cells and their progeny

Gianì

Pandini

Scalisi

et al. 2019

Endocrine-Related Cancer

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Thyroid cancer incidence is increased in volcanic areas where environment pollution biocontaminates residents. Tungsten (W) is the most increased heavy metal in drinking water of Mount Etna volcanic area where it exceeds the normal range in the urine of 27% inhabitants. The possible connection between increased tungsten and thyroid cancer has never been studied. We investigated in vitro the effect tungsten on both human thyrocytes in primary culture, thyrospheres (aggregates of stem/precursor thyroid cells) and thyrocytes differentiated from tungsten-exposed thyrospheres. Chronic exposure to low-dose (nanomolar range, as in the urines of volcanic area residents) soluble tungsten had major biological effects on thyroid stem/precursor cells, promoting growth with a biphasic (hormetic) dose-response and reducing apoptosis. No such effects were observed in mature thyrocytes. In addition, tungsten-exposed thyrospheres had abnormal expression of genes commonly altered also in thyroid cancer and increased activation of the DNA-repair proteins H2AX and 53BP1. Moreover, exposure to tungsten decreased thyrosphere differentiation, as indicated by the reduced expression of thyroid-specific genes in derived thyrocytes that also showed preneoplastic changes such as increased anchorage-independent growth, clonogenic growth and migration capacity. The mechanism of action of tungsten on thyroid stem/precursor cells is unclear but involves membrane G-proteins and activation of the ERK signaling pathway. These data indicate that chronic exposure to slightly increased tungsten, harmless for mature thyrocytes, importantly affects the biology of stem/precursor thyroid cells and of their progeny, inducing characteristics of preneoplastic transformation.

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“…Further proposed mechanisms include metabolic dysfunction induced through alterations in the gut microbiome [42][43][44][45] and thyroid dysfunction in pregnancy and in newborns. [46][47][48] Prenatal exposures to air pollution have been associated with sex-dependent effects on infant lung function, 49 childhood asthma, 50,51 neurodevelopment, 14,52,53 and metabolic outcomes, including childhood body composition, 15 neonatal birth weight, 54 and adult eating behavior as well as weight gain in animal studies. 55,56 The mechanisms leading to sex differences in the associations of fetal exposure to PM are not well understood.…”

Section: Biological Mechanismsmentioning

confidence: 99%

Association of Prenatal and Perinatal Exposures to Particulate Matter With Changes in Hemoglobin A_1c Levels in Children Aged 4 to 6 Years

et al. 2019

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IMPORTANCE Environmental risk factors for childhood type 2 diabetes, an increasing global problem, are understudied. Air pollution exposure has been reported to be a risk factor for this condition. OBJECTIVE To examine the association between prenatal and perinatal exposures to fine particulate matter with a diameter less than 2.5 μm (PM 2.5) and changes in hemoglobin A 1c (HbA 1c), a measure of glycated hemoglobin and marker of glucose dysregulation, in children aged 4 to 7 years. DESIGN, SETTING, AND PARTICIPANTS The Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) study, a birth cohort study conducted in Mexico City, Mexico, recruited pregnant women from July 3, 2007, to February 21, 2011, through public health maternity clinics. The present analysis includes 365 mother-child pairs followed up until the child was approximately 7 years of age. This study included data from only study visits at approximately 4 to 5 years (visit 1) and 6 to 7 years (visit 2) post partum because HbA 1c levels were not measured in earlier visits. The data were analyzed from March 11, 2018, to May 3, 2019. EXPOSURES Daily PM 2.5 exposure estimates at participants' home addresses from 4 weeks prior to mothers' date of last menstrual period (LMP), a marker of the beginning of pregnancy, to 12 weeks after the due date. Exposure was estimated from satellite measurements and calibrated against ground PM 2.5 measurements, land use, and meteorological variables. MAIN OUTCOMES AND MEASURES Outcomes included HbA 1c levels at 4 to 5 years and 6 to 7 years of age, and the change in the level from the former age group to the latter. RESULTS The sample included 365 children, of whom 184 (50.4%) were girls. The mean (range) age of the children was 4.8 (4.0-6.4) years at visit 1, and 6.7 (6.0-9.7) years at visit 2. At the time of delivery, the mean (range) age of the mothers was 27.7 (18.3-44.4) years, with a mean (range) prepregnancy body mass index of 26.4 (18.5-43.5). The mean (SD) prenatal PM 2.5 exposure (22.4 μg/m 3 [2.7 μg/m 3 ]) was associated with an annual increase in HbA 1c levels of 0.25% (95% CI,

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Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function

Cited by 63 publications

References 36 publications

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Effect of low-dose tungsten on human thyroid stem/precursor cells and their progeny

Association of Prenatal and Perinatal Exposures to Particulate Matter With Changes in Hemoglobin A_1c Levels in Children Aged 4 to 6 Years

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Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function

Cited by 63 publications

References 36 publications

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities

Effect of low-dose tungsten on human thyroid stem/precursor cells and their progeny

Association of Prenatal and Perinatal Exposures to Particulate Matter With Changes in Hemoglobin A1c Levels in Children Aged 4 to 6 Years

Contact Info

Product

Resources

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Association of Prenatal and Perinatal Exposures to Particulate Matter With Changes in Hemoglobin A_1c Levels in Children Aged 4 to 6 Years