Association of prenatal exposure to bisphenols and birth size in Zhuang ethnic newborns

Liang, Jun; Liu, Shun; Liu, Tao; Chun, Yang; Wu, Yanan; Tan, Hui; Wei, Bincai; Ma, Xiaoyun; Feng, Bao-Ying; Jiang, Qunjiao; Huang, Dongping; Qiu, Xiaoqiang

doi:10.1016/j.chemosphere.2020.126422

Cited by 59 publications

(36 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, due to the high percentage of concentrations below the LOD, we were not able to study the associations for third trimester BPS. Two studies investigating maternal BPF urine concentrations during pregnancy showed an inverse relationship with birth weight [29,30]. Three studies showed no association of BPF with birth weight, as in our study [9,11,31].…”

Section: Discussionsupporting

confidence: 60%

“…Previous studies assessing the associations of maternal BPS urine concentrations with fetal growth measures during pregnancy and at birth showed inconsistent results [9,11,12,[29][30][31]. In two prospective cohort Values are odds ratios (95% confidence intervals) from binary logistic regression models that reflect the risk of preterm birth and small size for gestational age at birth for detected bisphenol concentrations, as compared to the reference group (undetected concentrations).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

et al. 2021

View full text Add to dashboard Cite

Background Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

show abstract

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The participants were selected from the Guangxi Zhuang Birth Cohort (GZBC) between June 2015 and May 2017. Details on the ongoing cohort have been described in our previous study (Liang et al 2020). In the present study, the mothers met the following enrollment criteria: (1) singleton pregnancy and gestational age < 13 weeks at enrollment; (2) intend to deliver at the study hospitals; (3) agreed to provide blood samples and birth tissues at delivery.…”

Section: Study Population and Sample Collectionmentioning

confidence: 99%

“…Bisphenol levels in maternal serum were measured via ultra-high performance liquid chromatographytandem mass spectrometry (UPLC-MS; Waters Xevo TQD) as previously described (Liang et al 2020).…”

Section: Maternal Serum Bisphenols Measurementmentioning

confidence: 99%

Effect of Prenatal Exposure to Bisphenols on Newborn Leucocyte Telomere Length: A Prospective Birth Cohort Study in China

Liang

Shao

Huang

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Telomere length (TL) at birth is related to future diseases and long-term health. Bisphenols exhibit toxic effects and can cross the placenta barrier. However, the effect of prenatal exposure to bisphenols on newborn TL remains unknown. We aimed to explore the effects of prenatal exposure to bisphenols (i.e., bisphenol A (BPA), bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and tetrabromobisphenol A (TBBPA)) on relative TL in newborns. A total of 801 mother–infant pairs were extracted from the Guangxi Zhuang Birth Cohort (GZBC). The relationships between bisphenol levels in maternal serum and relative TL in cord blood were examined by generalized linear models and restricted cubic spline (RCS) models. After adjusting for confounders, we observed a 3.19% (95% CI: -6.08%, -0.21%) reduction in relative cord blood TL among mothers ≥ 28 years with each 1-fold increase of BPS. However, each 1-fold increase of TBBPA, a 3.31% (95% CI: 0.67%, 6.01%) increased in relative cord blood TL among mothers < 28 years. The adjusted RCS models also revealed similar results (P overall < 0.05, P non-linear > 0.05). This is the first study to show a positive association between serum TBBPA levels and newborn relative TL among younger mothers. However, BPS levels were inversely correlated with TL in fetus born to older mothers. The results suggest fetuses of older pregnant women are more sensitivity to BPS exposure and accelerated aging or BPS-related diseases in later life may stem from early-life exposure.

show abstract

“…Data between June 2015 and May 2018 for this study were extracted from the GZBC. Details on the ongoing GZBC have been introduced in our previous study [18]. In the present study, a total of 1239 mothers were extracted out for TL detection.…”

Section: Study Population and Data Collectionmentioning

confidence: 99%

Maternal Overweight but Not Paternal Overweight Before Pregnancy is Associated With Shorter Newborn Telomere Length: Evidence From Guangxi Zhuang Birth Cohort in China

Wei¹,

Shao²,

Liang³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Telomere length (TL) is variable at birth and is inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results in adverse offspring health outcomes, especially shorter newborn TL. However, a newborn’s genetic endowment is equally derived from both parents, the association between parental pre-pregnancy BMI and newborn TL has been rarely discussed. We aimed to determine the association between parental pre-pregnancy BMI and newborn TL. Methods: A total of 1082 parent-newborn pairs were recruited from the Guangxi Zhuang Birth Cohort (GZBC). TL in cord blood was measured using quantitative real-time polymerase chain reaction (qPCR) and expressed as the ratio of telomere copy number to single-copy gene number (T/S). A series of linear regressions were performed to assess the associations between parental pre-pregnancy BMI and newborn TL.Results: Mothers who were overweight before pregnancy had significantly shorter cord blood telomere length in their newborns than those who were normal weight before pregnancy [percentage change: −8.17% (95% CI: −14.69 to −0.92%; P=0.028)]. Further analysis of the combined effects of parental weight status on newborn TL showed that TL was significantly shortened among newborns whose mothers were overweight and fathers were of healthy weight when compared with those whose mothers and fathers were both of normal weight [percentage change: −8.59% (95% CI: −15.47 to −1.14%; P=0.025)]. Subgroup analysis indicated these effects were more pronounced among male newborns and those whose paternal age <31 years or maternal age ≥28 years at delivery. Conclusions: Maternal pre-pregnancy overweight, but not paternal pre-pregnancy overweight is associated with shorter newborn TL. Weight control in reproductive women and effective eugenics intervention programs may be of particular benefit for improving longevity and life quality of offspring.

show abstract

Association of prenatal exposure to bisphenols and birth size in Zhuang ethnic newborns

Cited by 59 publications

References 73 publications

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Effect of Prenatal Exposure to Bisphenols on Newborn Leucocyte Telomere Length: A Prospective Birth Cohort Study in China

Maternal Overweight but Not Paternal Overweight Before Pregnancy is Associated With Shorter Newborn Telomere Length: Evidence From Guangxi Zhuang Birth Cohort in China

Contact Info

Product

Resources

About