Association of prepubertal obesity with pubertal development in Chinese girls and boys: A longitudinal study

Li, Wenyan; Liu, Qin; Deng, Xu; Chen, Yiwen; Yang, Bo; Huang, Xin; Østbye, Truls

doi:10.1002/ajhb.23195

Cited by 32 publications

(30 citation statements)

References 37 publications

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“…According to results from studies reported in Table , girls with obesity enter puberty earlier compared with girls with normal weight . An explanation for the early onset of puberty in these girls might be found in the secretion of adipokines.…”

Section: The Onset Of Puberty In Girlsmentioning

confidence: 97%

“…The association between obesity and puberty onset in boys is rather controversial compared with findings in girls. Most studies reported an early onset of puberty in boys associated with increased BMI, while others reported no associations at all or a delayed onset of puberty (Table ) . The presence of excessive adipose tissue can be involved in puberty onset in boys as the secretion of adipokines can modulate both adrenarche and gonadarche.…”

Section: The Onset Of Puberty In Boysmentioning

confidence: 99%

“…leptin. Thereby, differences in puberty measurements could explain variations in the age of puberty onset between boys and girls within different studies or across continents, countries, and ethnicities (Figure ) . In addition, the inclusion of a proper age range (8‐16 years) is important when assessing the onset of puberty .…”

Section: Limitations and Future Research Directionsmentioning

confidence: 99%

“…Additionally, it is important that all studies use the same anthropometric standards and sex‐specific cut‐offs . Specifically in children, BMI is often dependent on age and growth spurts . Thereby, BMI is a less accurate measurement in case of growth spurts .…”

Section: Limitations and Future Research Directionsmentioning

confidence: 99%

“…they develop sexual characteristics and obtain reproductive functions . Although many studies have shown associations between obesity and puberty, the biological mechanisms underlying obesity and puberty onset remain unclear. Hereafter, we review in detail the role of adipokines in the onset of puberty in childhood obesity.…”

Section: Introductionmentioning

confidence: 99%

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Adipokines: A gear shift in puberty

et al. 2020

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In this review, we discuss the role of adipokines in the onset of puberty in children with obesity during adrenarche and gonadarche and provide a clear and detailed overview of the biological processes of two major players, leptin and adiponectin. Adipokines, especially leptin and adiponectin, seem to induce an early onset of puberty in girls and boys with obesity by affecting the hypothalamic-pituitarygonadal (HPG) axis. Moreover, adipokines and their receptors are expressed in the gonads, suggesting a role in sexual maturation and reproduction. All in all, adipokines may be a clue in understanding mechanisms underlying the onset of puberty in childhood obesity and puberty onset variability. K E Y W O R D S adipokines, obesity, puberty

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Section: The Onset Of Puberty In Girlsmentioning

confidence: 97%

Section: The Onset Of Puberty In Boysmentioning

confidence: 99%

Section: Limitations and Future Research Directionsmentioning

confidence: 99%

Section: Limitations and Future Research Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adipokines: A gear shift in puberty

et al. 2020

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Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls

et al. 2020

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IMPORTANCEThe initial clinical sign of pubertal onset in girls is breast gland development (thelarche). Although numerous studies have used recalled age at menarche (first menstruation) to assess secular trends of pubertal timing, no systematic review has been conducted of secular trends of thelarche.OBJECTIVES To systematically evaluate published data on pubertal timing based on age at thelarche and evaluate the change in pubertal onset in healthy girls around the world.DATA SOURCES A systematic literature search was performed in PubMed and Embase of all original peer-reviewed articles published in English before June 20, 2019.STUDY SELECTION Included studies used clinical assessment of breast development in healthy girls and used adequate statistical methods, including the reporting of SEs or CIs. The quality of the articles was evaluated by assessing study design, potential sources of bias, main characteristics of the study population, and methods of statistical analysis. DATA EXTRACTION AND SYNTHESISIn accordance with PRISMA guidelines, all articles were assessed for eligibility independently by 2 authors. Weighted regression analysis was performed using a random-effects model. MAIN OUTCOMES AND MEASURESStudies examining age at thelarche (development of Tanner breast stage 2) in healthy girls. RESULTSThe literature search resulted in a total of 3602 studies, of which 30 studies fulfilled the eligibility criteria. There was a secular trend in ages at thelarche according to race/ethnicity and geography. Overall, the age at thelarche decreased 0.24 years (95% CI, −0.44 to −0.04) (almost 3 months) per decade from 1977 to 2013 (P = .02). CONCLUSIONS AND RELEVANCEThe age at thelarche has decreased a mean of almost 3 months per decade from 1977 to 2013. A younger age at pubertal onset may change current diagnostic decision-making. The medical community needs current and relevant data to redefine "precocious puberty," because the traditional definition may be outdated, at least in some regions of the world.

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Assessment of the median ages at sexual maturation stages of Brazilian schoolchildren according to overweight status and type of school over a 5‐year period: 2007–2012/2013

Matsuo

Adami

Silva

et al. 2021

American J Hum Biol

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Objectives A secular trend of earlier puberty has been observed in girls, and, although more uncertain in boys, is associated with an increasing trend in the prevalence of overweight and obesity. We aimed to compare the median ages of sexual maturation stages in schoolchildren from a city in southern Brazil over a 5‐year period, according to weight status and type of school. Methods Two cross‐sectional studies were performed in 2007 and 2012/2013, including 2215 and 1614 schoolchildren, respectively. Body mass index z‐scores were calculated and categorized as either nonoverweight or overweight (including obesity). The type of school was categorized as either public or private. Sexual maturation was self‐assessed according to the Tanner stages. Mann–Whitney and Kruskal–Wallis tests were performed to compare the median ages of sexual maturation stages. Results The median age decreased for almost all stages over the 5‐year period in both sexes. In boys, the decrease ranged from 0.3 to 1.0 years (stages 2, 3, 4, and 5 for genitalia, and stages 2 and 4 for pubic hair), and from 0.3 to 0.7 years (stages 2, 3, and 4 for breast, and stages 3, 4, and 5 for pubic hair). In 2012, overweight students had lower median ages for most stages compared to those in 2007, especially in girls. Differences by type of school were balanced across years. Conclusions The median age of Tanner's stages after 5 years was reduced in both sexes. In overweight girls, the reduction was more pronounced. The results by type of school were inconsistent.

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Association of prepubertal obesity with pubertal development in Chinese girls and boys: A longitudinal study

Cited by 32 publications

References 37 publications

Adipokines: A gear shift in puberty

Adipokines: A gear shift in puberty

Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls

Assessment of the median ages at sexual maturation stages of Brazilian schoolchildren according to overweight status and type of school over a 5‐year period: 2007–2012/2013

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