Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014

Abstract

IMPORTANCE Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx). OBJECTIVE To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence. DESIGN, SETTING, AND PARTICIPANTSA total of 18 060 patients who underwent PNx between 2007 and 2014 were selected from Truven Health MarketScan Research Databases. We selected those patients who underwent PNx as an inpatient from 2007 and set the surgery date as the index date. Overall, a total of 21 445 patients with International Classification of Diseases, Ninth Revision, Clinical Modification code of 55.4 were identified from 2007 to 2015.MAIN OUTCOMES AND MEASURES The annual trend of benign pathologic findings was described as an actual number and as a proportion. Univariate and multiple analyses were performed to investigate factors predictive of a benign final pathologic diagnosis, including type of preoperative imaging modality or performance of a renal mass biopsy. RESULTSAmong the 18 060 patients, mean (SD) age was 57 (12) years, and there were 10637 (58.9%) men and 7423 (41.1%) women. The overall prevalence of benign pathologic findings was 30.9% and the annual trends demonstrated a prevalence of over 30% for nearly every year of the study period. On univariate analysis, the performance of magnetic resonance imaging (MRI) and renal mass biopsy was associated with benign pathologic findings (P = .02 and P < .001, respectively). On multivariable analysis, female sex (odds ratio [OR], 0.62; 95% CI, 0.58-0.66; P < .001), older age (>65 years) (OR, 0.99; 95% CI, 0.99-0.99; P < .001), and computed tomography (CT) only preoperative imaging (OR, 1.16; 95% CI, 1.05-1.28; P = .004) were associated with benign pathologic findings after PNx. CONCLUSIONS AND RELEVANCEWe found that the overall prevalence of benign pathologic findings after PNx was higher than the literature suggests, with consistent year-over-year rates exceeding 30%. Female sex, older age (>65 years), and CT only preoperative imaging were predictive of a benign tumor. Further elucidation concerning covariates associated with a benign diagnosis should be the focus of future investigations to identify a cohort of patients who could potentially avoid unnecessary surgical intervention.

Gender-Related Approach to Kidney Cancer Management: Moving Forward

“…This implies that women are submitted to NSS for benign lesions more often than men, which could therefore have been avoided. In a large cohort study on 18,060 patients submitted to NSS (58.9% males, 41.1% females) [16], 5588 (30.9%) had a benign histological diagnosis at final pathology. In this group of benign lesions, female gender was prominent, as compared with the malignant tumor group (48.9% vs. 37.6%, respectively), with women having a 0.62-fold increased risk of benign histological diagnosis than men (OR: 0.62, 95% CI: 0.58-0.66; p < 0.001).…”

Automated differentiation of benign renal oncocytoma and chromophobe renal cell carcinoma on computed tomography using deep learning

“…Surgery is the primary treatment for clinically localized kidney tumours. Seventy percent of resected renal cell tumours are diagnosed as RCC, while the remaining tumours are benign ; therefore, 30% of patients are unnecessarily subjected to surgical resection, which is associated with a 30% risk of complications, including an ~15% rate of high grade complications . In addition, resection of benign tumours is estimated to incur a significant healthcare costs, approaching $100 m on an annual basis in the USA .…”

Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: a multicenter study

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