Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China

Chen, Yuhong; Lu, Jieli; Huang, Yun; Wang, Tiange; Xu, Yu; Xu, Min; Li, Mian; Wang, Weiqing; Li, Donghui; Bi, Yufang; Ning, Guang

doi:10.1210/jc.2012-2517

Cited by 107 publications

(161 citation statements)

References 17 publications

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“…Our finding was somewhat consistent with the results of a crosssectional study conducted in Jiading, a suburb of Shanghai [8], which reported that PSI might reduce the prevalence of diabetes and metabolic syndrome. Additionally, our findings showed that PSI was negatively correlated with TG and positively correlated with HDL-C.…”

supporting

confidence: 92%

The potential long-term effect of previous schistosome infection may reduce the risk factors for cardiovascular diseases

Shen

et al. 2014

International Journal of Cardiology

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supporting

confidence: 92%

The potential long-term effect of previous schistosome infection may reduce the risk factors for cardiovascular diseases

Shen

et al. 2014

International Journal of Cardiology

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“…People in a rural area in China who have a history of Schistosoma infections compared to endemic controls who never suffered from schistosomiasis had a lower body mass index and fasting blood glucose levels, and reduced prevalence of T2D and metabolic syndrome [16]. Accordingly, prevalence of lymphatic filariasis was significantly lower in diabetic subjects than nondiabetic subjects in Chennai, India [15].…”

Section: Discussionmentioning

confidence: 99%

“…Recent cross-sectional studies in India, Indonesia, rural China, and in aborigines in Australia revealed that the prevalence of helminth infections in T2D patients is significantly lower than in nondiabetic controls, independent of socioeconomic differences in income and nutrition, suggesting that helminth infections may indeed prevent or delay the onset of T2D [15,16,17,18]. Possible helminth-mediated protective mechanisms include the downregulation of proinflammatory immune responses that are associated with T2D, the induction of type 2 immune responses, the promotion of fatty acid uptake, or a stronger expression of genes that are associated with insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

et al. 2016

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Helminths induce type 2 immune responses and establish an anti-inflammatory milieu in their hosts. This immunomodulation was previously shown to improve diet-induced insulin resistance which is linked to chronic inflammation. In the current study, we demonstrate that infection with the filarial nematode Litomosoides sigmodontis increased the eosinophil number and alternatively activated macrophage abundance within epididymal adipose tissue (EAT) and improved glucose tolerance in diet-induced obese mice in an eosinophil-dependent manner. L. sigmodontis antigen (LsAg) administration neither altered the body weight of animals nor adipose tissue mass or adipocyte size, but it triggered type 2 immune responses, eosinophils, alternatively activated macrophages, and type 2 innate lymphoid cells in EAT. Improvement in glucose tolerance by LsAg treatment remained even in the absence of Foxp3+ regulatory T cells. Furthermore, PCR array results revealed that LsAg treatment reduced inflammatory immune responses and increased the expression of genes related to insulin signaling (Glut4, Pde3b, Pik3r1, and Hk2) and fatty acid uptake (Fabp4 and Lpl). Our investigation demonstrates that L. sigmodontis infection and LsAg administration reduce diet-induced EAT inflammation and improve glucose tolerance. Helminth-derived products may, therefore, offer new options to improve insulin sensitivity, while loss of helminth infections in developing and developed countries may contribute to the recent increase in the prevalence of type 2 diabetes.

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“…The measurements of triglycerides, total cholesterol, low‐density lipoprotein cholesterol and high‐density lipoprotein cholesterol were carried out using an enzymatic colorimetric method (LX‐20; Beckman, Brea, CA, USA) by the Shanghai Institute of Endocrinology and Metabolism; and the measurement of HbA1c was carried out by a high‐performance liquid chromatography method (Bio‐Rad Laboratories, Hercules, CA, USA)22.…”

Section: Methodsmentioning

confidence: 99%

Ideal glycated hemoglobin cut‐off points for screening diabetes and prediabetes in a Chinese population

Liu

Xiao

Sun

et al. 2016

J of Diabetes Invest

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Aims/IntroductionThe aims of the present study were to evaluate the diagnostic value of fasting plasma glucose, 2‐h postload plasma glucose and glycosylated hemoglobin (HbA1c) measurements in the screening of diabetes and prediabetes, and to determine the cut‐off point of HbA1c in the diagnosis of diabetes and prediabetes in a Chinese population.Materials and MethodsA total of 7,611 individuals aged 40 years or older, who did not have a prior history of diabetes, were randomly selected in the Changchun area. For each participant, a questionnaire was completed, and a physical examination and an oral glucose tolerance test were carried out. The values of fasting plasma glucose, 2‐h postload plasma glucose and HbA1c were compared by area under the receiver operating characteristic curves. The Youden index was used to identify the optimal cut‐off point of HbA1c in the diagnosis of diabetes and prediabetes.ResultsThe prevalence of newly diagnosed diabetes and prediabetes was 12.71% and 29.39%, respectively. In participants with newly diagnosed diabetes, the area under the receiver operating characteristic curve was 0.8368 for fasting plasma glucose, 0.9330 for 2‐h postload plasma glucose and 0.8064 for HbA1c; whereas for prediabetes, these values were 0.8022, 0.9288 and 0.6895, respectively. In addition, an HbA1c threshold of 6.3% showed the highest Youden index (0.4799) for detecting diabetes; furthermore, an HbA1c threshold of 5.8% showed the highest Youden index (0.2866) for detecting prediabetes.ConclusionsHbA1c ≥6.3% (45 mmol/mol) and between 5.8% and 6.2% (40–44 mmol/mol) were the optimal cut‐off values for the diagnosis of diabetes and prediabetes, respectively, in a Chinese population.

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Association of Previous Schistosome Infection With Diabetes and Metabolic Syndrome: A Cross-Sectional Study in Rural China

Cited by 107 publications

References 17 publications

The potential long-term effect of previous schistosome infection may reduce the risk factors for cardiovascular diseases

The potential long-term effect of previous schistosome infection may reduce the risk factors for cardiovascular diseases

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice

Ideal glycated hemoglobin cut‐off points for screening diabetes and prediabetes in a Chinese population

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