Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients

Lee, R.H.; Curtis, J.; Drake, M.T.; Bobo Tanner, S.; Lenert, L.; Schmader, K.; Pieper, C.; North, R.; Lyles, K.W.

doi:10.1007/s00198-023-06912-6

Osteoporos Int

2023

DOI: 10.1007/s00198-023-06912-6

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Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients

R.H. Lee,

J. Curtis,

M.T. Drake

et al.

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2024

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Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model

Ahn,

Seo,

Jung

et al. 2024

Sci Rep

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Many older patients with COVID-19 likely have co-morbid osteoporosis. We investigated the clinical outcomes of COVID-19 patients with osteoporosis. This was a retrospective cohort study using national claims data from Korea encoded in the common data model. Patients aged ≥ 50 years diagnosed with COVID-19 infection between January 2020 and April 2022 were included and stratified into two groups according to a history of osteoporosis. Clinical outcomes of COVID-19 infection were analyzed using logistic regression analysis after large-scale propensity score stratification. Of the 597,011 patients with COVID-19 included in the study, 105,172 had a history of osteoporosis. In patients with a history of osteoporosis, the odds of mortality decreased (odds ratio [OR] 0.82, P < 0.002), whereas most clinical outcomes of COVID-19 did not exhibit differences compared to those without such a history. Osteoporosis patients with a history of fractures showed increased odds of pneumonia, hospitalization, major adverse cardiac events, venous thromboembolism, and mortality, compared to patients without osteoporosis (ORs 1.34–1.58, P < 0.001 to P = 0.001). Our study suggests that patients with severe osteoporosis who have experienced fractures have an elevated risk of severe complications with COVID-19, while osteoporosis patients without fractures who have sought medical attention have a lower risk of mortality.

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Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model

Ahn,

Seo,

Jung

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients

Cited by 1 publication

References 34 publications

Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model

Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model

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