Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population

Yuan, Jun; Zhang, Yan; Yan, Fu-tang; Zheng, Xiao

doi:10.1016/j.bjid.2016.08.003

Cited by 4 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the variation frequency of rs13361707 in healthy subjects was 72.88%, which was similar to the 71.8% reported by previous research (Li et al, 2020). Otherwise, it was different from the Yuan et al (2016). In our study, the variation frequency of rs3792822 was similar to previous reports (Yuan et al, 2016).…”

Section: Discussionsupporting

confidence: 90%

“…Otherwise, it was different from the 80.86% reported by Yuan et al (2016) . In our study, the variation frequency of rs3792822 was similar to previous reports ( Yuan et al, 2016 ). The variation frequency of rs10074991 was 72.88% in our study, which differed from the 80.2% reported by Kim et al (2014) .…”

Section: Discussioncontrasting

confidence: 81%

“…Previous studies have found that gene polymorphisms are closely related to drug metabolism and disease occurrence ( Wang et al, 2013 ; Mei et al, 2015 ; Guo et al, 2021 ). However, there are few studies on the correlation between AMPK gene polymorphisms and gastric cancer, rectal cancer, diabetes mellitus and Hepatitis B virus infection ( Lee et al, 2014 ; Yuan et al, 2016 ; Chen et al, 2018 ; Jiang et al, 2018 ; Li et al, 2020 ). Our previous study identified that the PRKAA2 gene polymorphism had a significant effect on PHN susceptibility ( Mei et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Yang

Chen

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a pivotal regulatory protein in energy metabolism. In a pilot study, we found that AMPK-associated energy metabolism imbalance in neurons contributes to the occurrence and maintenance of neuropathic pain (NeP). This study aimed to explore the relationship between genetic polymorphisms of AMPK gene (Rs13361707, rs3792822, and rs10074991) in PRKAA1 and postherpetic neuralgia (PHN) in Chinese individuals. Hundred and thirty two patients with PHN and 118 control individuals were enrolled in this study. All blood samples were shuffled and blinded to the person performing the haplotype analysis. Rs13361707, rs3792822, and rs10074991 PRKAA1 genotypes were identified in all participants. Dominant and recessive models were used for evaluating the association between these nucleotide polymorphisms and PHN susceptibility. A haplotype analysis of PHN patients and healthy controls was performed. Clinical characteristics between the two groups were not significantly different (p > 0.05) except that the ages in control subjects were younger than the PHN patients (p < 0.05). Genotypes and allele frequencies are significantly different between the PHN patients and control subjects for the rs13361707 and rs10074991 polymorphisms (p < 0.05), but not for rs3792822 (p > 0.05). In addition, the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence, but TCA was positively correlated with PHN (p < 0.05). Our results indicate that PRKAA1 gene polymorphisms rs13361707 and rs10074991 were associated with a risk of PHN, and that the CCG haplotype of rs13361707-rs3792822-rs10074991 correlated negatively with PHN occurrence in haplotype analysis. TCA was positively associated with PHN in Chinese individuals.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Yang

Chen

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…CXCR2P1 is the pseudogene of the IL-8 receptor and is mainly involved in neutrophil migration (51). Protein kinase PRKAA1, the catalytic subunit of AMPK, is expressed principally in macrophages and lymphocytes and plays a pivotal role in inducing proinflammatory signals through TAK1 and NFkB activation (52). AMPK promotes inflammation, innate immunity, and antiviral defenses through modulation of the host protein, a stimulator of IFN gene signaling (STING) (53).…”

Section: Discussionmentioning

confidence: 99%

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Gonçalves¹,

Bonduelle²,

Soria³

et al. 2019

Journal of Clinical Investigation

View full text Add to dashboard Cite

METHODS. This randomized phase I/II clinical study (n = 60 healthy subjects aged 18-45 years old) used transcriptomic analysis to discover early biomarkers of immune response quality after transcutaneous (t.c.), intradermal (i.d.), and intramuscular (i.m.) administration of a trivalent influenza vaccine (TIV, season 2012-2013, 1:1:1 ratio). Safety and immunogenicity (hemagglutinin inhibition [HI], microneutralization [MN] antibodies, and CD4+ and CD8+ effector T cells) were measured at baseline day 0 (d0) and at d21. Blood transcriptome was analyzed at d0 and d1. RESULTS. TIV-specific CD8+ granzyme B+ (GRZ) T cells appeared in more individuals immunized by the t.c. and i.d. routes, whereas immunization by the i.d. and i.m. routes prompted high levels of HI antibody titers and MN against A/H1N1 and A/H3N2 influenza viral strains. The early innate gene signature anticipated immunological outcome by discriminating 2 clusters of individuals with either distinct humoral or CD8 cytotoxic responses. Several pathways explained this dichotomy and confirmed that 9 genes and the serum level of CXCL10 were correlated with either TIV-specific cytotoxic CD8+GRZ+ T cell or antibody responses. A logistic regression analysis demonstrated that these 9 genes and the serum levels of CXCL10 at d1/d0 best predicted TIV-specific CD8+GRZ+ T cell and antibody responses at d21. CONCLUSION. This study provides new insight into the impact of immunization routes and innate signature in the quality of adaptive immune responses. TRIAL REGISTRATION. This study has been registered at ClinicalTrials.gov (NCT01707602).

show abstract

“…AMPK was a key enzyme widely expressed in cells that regulated various physiological functions such as cell proliferation and autophagy, tumorigenesis, and energy homeostasis (102). And it played an important role in innate immune and inflammation responses (103). As a subunit of AMPK, PRKAA1 played a similar role as AMPK.…”

Section: Hub Genes Functional Analysismentioning

confidence: 99%

Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling

et al. 2022

View full text Add to dashboard Cite

Sepia esculenta is a popular economic cephalopod with high yield, delicious meat, and rich nutrition. With the rapid development of heavy industry and medical industry, a large amount of waste has been released into the ocean recklessly in recent years, inducing a significant increase in the content of heavy metals, especially cadmium (Cd) and copper (Cu), in the ocean. This phenomenon significantly affects the growth and development of S. esculenta, causing a serious blow to its artificial breeding. In this study, transcriptome analysis is used to initially explore immune response mechanisms of Cd and Cu co-exposed juvenile S. esculenta. The results show that 1,088 differentially expressed genes (DEGs) are identified. And DEGs functional enrichment analysis results suggests that co-exposure may promote inflammatory and innate immune responses in juvenile S. esculenta. Fifteen key genes that might regulate the immunity of S. esculenta are identified using protein-protein interaction (PPI) network and KEGG enrichment analyses, of which the three genes with the highest number of interactions or involve in more KEGG pathways are identified as hub genes that might significantly affect the immune response processes. Comprehensive analysis of PPI network and KEGG signaling pathway is used for the first time to explore co-exposed S. esculenta juvenile immune response processes. Our results preliminarily reveal immune response mechanisms of cephalopods exposed to heavy metals and provide a valuable resource for further understanding of mollusk immunity.

show abstract

Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population

Cited by 4 publications

References 30 publications

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling

Contact Info

Product

Resources

About