Association of pro‐ and anti‐inflammatory cytokines in preeclampsia

Aggarwal, Ruby; Jain, Arun K.; Mittal, Pratima; Kohli, Monika; Jawanjal, Poonam; Rath, Goutam

doi:10.1002/jcla.22834

Cited by 171 publications

(137 citation statements)

References 35 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…Obesity-induced metabolic dysfunction and pregnancy complications share mechanistic similarities. Specifically, proinflammatory factors such as HMGB1 [112][113][114][115], TNF-α [116,117], and IL-1β [118][119][120] play critical roles in the inflammation underlying both obesity and preeclampsia. These key inflammatory mediators when upregulated in obesity [102] may potentiate aberrant maternal inflammation that in turn contribute to the development of pregnancy disorders [121].…”

Section: Maternal Obesitymentioning

confidence: 99%

Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation

St-Germain

Castellana

Baltayeva

et al. 2020

IJMS

View full text Add to dashboard Cite

Inflammation is often equated to the physiological response to injury or infection. Inflammatory responses defined by cytokine storms control cellular mechanisms that can either resolve quickly (i.e., acute inflammation) or remain prolonged and unabated (i.e., chronic inflammation). Perhaps less well-appreciated is the importance of inflammatory processes central to healthy pregnancy, including implantation, early stages of placentation, and parturition. Pregnancy juxtaposed with disease can lead to the perpetuation of aberrant inflammation that likely contributes to or potentiates maternal morbidity and poor fetal outcome. Maternal obesity, a prevalent condition within women of reproductive age, associates with increased risk of developing multiple pregnancy disorders. Importantly, chronic low-grade inflammation is thought to underlie the development of obesity-related obstetric and perinatal complications. While diverse subsets of uterine immune cells play central roles in initiating and maintaining healthy pregnancy, uterine leukocyte dysfunction as a result of maternal obesity may underpin the development of pregnancy disorders. In this review we discuss the current knowledge related to the impact of maternal obesity and obesity-associated inflammation on uterine immune cell function, utero-placental establishment, and pregnancy health.

show abstract

Section: Maternal Obesitymentioning

confidence: 99%

Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation

St-Germain

Castellana

Baltayeva

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…The shift in the balance of M2/M1 macrophages towards M1 is explained by high levels of pro-inflammatory cytokines and low levels of anti-inflammatory cytokines within the preeclamptic placenta [107,108]. In addition to the altered cytokine production, there is also a cellular axis in the process of polarization.…”

Section: Monocyte–macrophage System During Pregnancymentioning

confidence: 99%

Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia

Vishnyakova

Elchaninov

Fatkhudinov

et al. 2019

IJMS

View full text Add to dashboard Cite

The proper functioning of the monocyte–macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte–macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte–macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.

show abstract

“…Excessive TNF- α causes thrombosis and TNF- α can activate immunocompetent cells in the decidual stroma, induce immune-mediated destruction and immune rejection, hinder the maintenance of pregnancy and embryo implantation, disrupt the homeostasis of the maternal uterine environment, and cause spontaneous abortion [ 16 , 18 , 19 ]. IL-6, which is produced by extravillous trophoblasts and cytotrophoblasts, plays an important role in the normal placental development and pregnancy success by regulating placental cell migration and invasion and trophoblast differentiation and proliferation [ 20 , 21 ]. However, the role of IL-6 in ACA-positive spontaneous abortion is controversial, as Krause et al [ 22 ] showed that the serum IL-6 was increased in ACA-positive pregnant mice, while Karakantza et al [ 23 ] reported the opposite result.…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Differentially Expressed Proteins in the Placenta of Anticardiolipin Antibody‐ (ACA‐) Positive Pregnant Mice after Anzi Heji Treatment

Xie

2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Anzi Heji (AZHJ) has been used to treat anticardiolipin antibody- (ACA-) positive pregnant women at risk of spontaneous abortion for many years. The aim of this study was to investigate the protective mechanism of AZHJ in a mouse model of ACA-positive pregnancy at risk of spontaneous abortion using label-free quantitative proteomics. Mice were divided into three groups: normal pregnant mice (control group), ACA-positive pregnant mice administered normal saline (model group), and ACA-positive pregnant mice administered AZHJ (AZHJ group). The model was established by injecting β 2 -glycoprotein I (GPI) into mice for 18 days. The DEPs and their functions were analyzed by label-free quantitative proteomic and bioinformatic analyses. The levels of IL-6, IL-10, ACA, and TNF- α in the serum and placentas of the mice were measured by enzyme-linked immunosorbent assays (ELISAs). Proteomic data were validated by western blot analysis. The abnormal serum and placental levels of IL-6, ACA, and TNF- α in the model group were reversed by AZHJ. There were 39 upregulated and 10 downregulated DEPs in the AZHJ group relative to the model group. Bioinformatic analysis revealed that the DEPs were mainly involved in nucleic acid binding, signal conduction, and posttranslational modification. The placental levels of T-cell immunoglobulin mucin 3 (Tim-3) and Toll-like receptor 4 (TLR4) expression and AKT phosphorylation in the three groups were consistent with the proteomic findings. Tim-3/AKT signaling is involved in maternal-fetal immune tolerance, while TLR4 is associated with inflammatory responses. Collectively, these results indicate that AZHJ may exert its protective effect in ACA-positive pregnant mice by regulating the maternal-fetal immune tolerance and inflammatory response.

show abstract

Association of pro‐ and anti‐inflammatory cytokines in preeclampsia

Cited by 171 publications

References 35 publications

Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation

Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation

Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia

Proteomic Analysis of Differentially Expressed Proteins in the Placenta of Anticardiolipin Antibody‐ (ACA‐) Positive Pregnant Mice after Anzi Heji Treatment

Contact Info

Product

Resources

About