Association of Progressive Systemic Sclerosis with Pulmonary Sarcoidosis. Just a Chance Occurrence?

Takahashi, Toru; Munakata, Mitsuru; Homma, Yukihiko; Kawakami, Yoshikazu

doi:10.2169/internalmedicine.36.435

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…The coexistence of sarcoidosis and systemic sclerosis is a rare phenomenon. Some authors regard this as a chance occurrence as the two diseases may run independent clinical courses 1 . We report a case of a young female who presented initially with symptoms suggestive of limited cutaneous systemic sclerosis and gradually developed cutaneous lesions and pulmonary involvement suggestive of sarcoidosis.…”

mentioning

confidence: 87%

Sarcoidosis associated systemic sclerosis: More than chance occurrence

Mahajan

Jindal

Kanwar

2012

The Journal of Dermatology

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confidence: 87%

Sarcoidosis associated systemic sclerosis: More than chance occurrence

Mahajan

Jindal

Kanwar

2012

The Journal of Dermatology

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“…Radiographically, 18 cases had ILD. Bilateral hilar lymphadenopathy (BHL) was found in 9 cases [2][3][4][5][6][7][8][9][10][11][12]. In our case, making the diagnosis of systemic sclerosis coincided with that of sarcoidosis, showing diffuse type of systemic sclerosis, elevation of serum ACE, and ILD without hilar adenopathy.…”

Section: Discussionmentioning

confidence: 72%

“…The association between systemic sclerosis and sarcoidosis has not been fully understood, but at least 24 cases Abbreviations are as follows: ACA anti-centromere antibody, ACE angiotensine converting enzyme, BHL bilateral hilar adenopathy, ILD interstitial lung disease suffering from both systemic sclerosis and sarcoidosis were found by review of literature [2][3][4][5][6][7][8][9][10][11][12]. The characteristics of the twenty-five cases including our case are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

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A case of sarcoidosis developing as sarcoid myopathy concomitant with systemic sclerosis and review of the literature

et al. 2011

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A 65-year-old man was diagnosed with systemic sclerosis on the basis of skin thickening and positivity of anti-Scl-70 antibodies. Because myogenic enzymes, such as creatinine phosphokinase and aldorase, were also elevated, myopathy or myositis associated with systemic sclerosis was considered. Muscle magnetic resonance imaging and gallium scintigraphy did not show abnormalities. Findings of muscle biopsy demonstrated presence of noncaseating granulomas with multinucleated giant cells. In addition, serum angiotensin-converting enzyme and lysozyme were elevated, and therefore a diagnosis of sarcoid myopathy was made. Further, renal sarcoidosis was revealed with renal biopsy. Prednisolone (40 mg/day) improved both the myopathy and nephritis. Sarcoid myopathy is a rare condition, but it should be considered when myogenic enzymes are elevated in the patient with systemic sclerosis. Further, muscle biopsy may be essential to make an accurate diagnosis in such condition.

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“…[2] Co-existence of these two diseases has been reported, but is rare. [3–5] Here, we describe the case of a 68-year-old Japanese woman who developed sarcoidosis 15 years after diagnosis of limited cutaneous systemic sclerosis (lcSSc).…”

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confidence: 99%