Association of proinflammatory cytokine tumor necrosis factor-α gene promoter -308 and -238 polymorphism with psoriasis in North Indian population

Wani, Aadil; Ganai, Bashir Ahmad; Akhtar, Tahseena; Narang, Tarun; Kaur, Rajinder

doi:10.4103/ejdv.ejdv_23_17

Cited by 2 publications

(5 citation statements)

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“…The present study shows that the mean serum value of TNF-α was significantly higher in psoriatic patients as compared to matched controls. This finding was consistent with a previously reported studies ( case-control studies with study population range of 30-200 subjects) from different geographical areas [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. However, two studies reported that TNF-α serum levels was not with significant differences between controls and psoriatic patients [56,92].…”

Section: Discussionsupporting

confidence: 92%

“…The serum TNF-α levels in psoriatic patients were highly significantly correlated with PASI and this finding was in agreement with that reported by others [33,37,40,41,43,45,48]. However, other studies did not confirm a significant correlation between PASI and TNF-α serum levels [31,34,38,39,47].…”

Section: Discussionsupporting

confidence: 91%

“…Tumor necrosis factor-α is a proinflammatory mediators that was over expressed in psoriasis [40]. Many cells produced TNF-α which include mast cells, antigen presenting cells in the skin, keratinocytes, monocytes and lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

“…Previous casecontrol studies and systematic review and metaanalysis all reported that plasma/serum TNF-α level was increased in psoriatic patients compared to controls [31-48, 56,72]. However, there was a conflicting findings regarding the correlation between psoriasis severity and serum/plasma levels of 33,34,[37][38][39][40][41]43,45,47,48] Interleukin-18 stimulate T-cells, natural killer (NK) cells, innate immunity enhancement and driven the immune response toward Th1 activity [78]. IL-18 produced by monocytes, keratinocytes, and macrophages [79].…”

Section: Introductionmentioning

confidence: 99%

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Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

Alobaidi

Alsamarai

2022

Egypt. J. Chem.

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To clarify the role of tumor necrosis factor-α (TNF-α), interleukin-18 (IL-18), osteopontin, lipoprotein (a) and paraoxonase in psoriasis in Iraqi community this study was conducted. Cross-sectional study included 94 subjects with psoriasis vulgaris, with a mean age of 37.5 ± 11.6 year. Serum osteopontin, IL-18 and TNF-α were determined using Enzyme linked immunosorbent assay kits. The mean serum levels of TNF-α, IL-18, osteopontin (OPN), and lipoprotein (a) (LP (a)) were significantly higher in individuals with psoriasis as compared to controls. In contrast, PON 1 mean serum value was significantly lower in psoriasis compared to controls. Odd ratio indicated a significant association between increase in TNF-α, IL-18, OPN and Lp(a) and the decrease in PON1 in our cohort study. Disease severity significantly correlated with serum levels of TNF-α, IL-18 and Lp (a), while inversely correlated with serum levels of PON 1. TNF-α was with high predictivity in monitoring psoriasis severity and response to treatment. The elevation of serum IL-18, OPN, LP(a) and reduction of PON1 indicated that these biomarkers may play a role in psoriasis pathogenesis. The significant correlation of serum levels of TNF-α, IL-18 and LP (a) with PASI and inverse correlation of PON1 with PASI are useful biomarkers for monitoring of disease severity and treatment

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

Alobaidi

Alsamarai

2022

Egypt. J. Chem.

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“…Regarding clinical picture of the patients, PASI score, our results were in accordance with that found by Elfarargy et al, 2014 who showed a positive significant correlation among the TNF-α serum levels and disease severity. This, also in consistent with Aadil et al, 2018 as revealed significant correlation among the TNF-α serum level and disease severity [11].…”

Section: Discussionsupporting

confidence: 92%

Progranulin/Tumor Necrosis Factor-\(\alpha\) ratio in Psoriasis Vulgaris

Sheir¹,

Badr

Hodeib

et al. 2022

JAMMR

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Background and Aim: In psoriasis, the proteins Tumor Necrosis Factor (TNF) and interleukin-6 (IL-6) are overexpressed and play important roles in the disease's progression. For treating psoriasis, biological drugs that target TNF signaling are quite successful. Embryogenesis, tissue repair, cancer, neuronal survival, host defense, and inflammation are all dependent on progranulin (PGRN). By competing with TNF binding to TNFR1/2, PGRN inhibits TNF-mediated signaling pathways and has anti-inflammatory properties in inflammatory arthritis models. The current research seeks to study the relationship between serum PGRN / TNF - \(\alpha\)and psoriasis vulgaris activity. Subjects & Methods: This study’s subjects were categorized into 2 groups: group 1 with 35 patients with psoriasis vulgaris, and group 2 of 30 healthy subjects with matched age and sex. Results: We discovered a significant increase in PGRN and TNF-\(\alpha\)in cases versus control. And we have found a significant decrease in PGRN/TNF-\(\alpha\)ratio in cases versus control. We also detected significant differences between the Psoriasis Area Severity Index (PASI) degree and the levels of PGRN and TNF-\(\alpha\), as well as the PGRN/TNF-\(\alpha\)ratio. We discovered a negative significant correlation between PASI and PGRN/TNF-\(\alpha\)ratio. Conclusion: Atsttrin exhibited potent anti-inflammatory properties due to its three modified granulin motifs and their associated linker regions. In the treatment of rheumatoid arthritis and contact dermatitis, PGRN and its derivative Atsttrin may be a potential therapeutic drug.

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Association of proinflammatory cytokine tumor necrosis factor-α gene promoter -308 and -238 polymorphism with psoriasis in North Indian population

Cited by 2 publications

References 0 publications

Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

Progranulin/Tumor Necrosis Factor-\(\alpha\) ratio in Psoriasis Vulgaris

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