2015
DOI: 10.1371/journal.pone.0129610
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Association of Protein Translation and Extracellular Matrix Gene Sets with Breast Cancer Metastasis: Findings Uncovered on Analysis of Multiple Publicly Available Datasets Using Individual Patient Data Approach

Abstract: IntroductionMicroarray analysis has revolutionized the role of genomic prognostication in breast cancer. However, most studies are single series studies, and suffer from methodological problems. We sought to use a meta-analytic approach in combining multiple publicly available datasets, while correcting for batch effects, to reach a more robust oncogenomic analysis.AimThe aim of the present study was to find gene sets associated with distant metastasis free survival (DMFS) in systemically untreated, node-negat… Show more

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Cited by 5 publications
(6 citation statements)
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“…Indeed, GSEA analysis confirmed this premise: lymph node metastasis was associated with number of pathways that include transcription factors of the NF-κB family which were previously associated with the lymph node metastasis of breast tumors [64]. On the other hand, distant metastasis was primarily connected to pathways regulating stronger mechanisms related to cell cycle and proliferation control, in agreement with Chowdhury et al [65]. Other key pathways related to distant metastasis involved fibrinolytic proteases including urokinase plasminogen activator (uPA), well known in term of distant metastasis in breast cancer [66].…”
Section: Lymph Node and Distant Metastasis Are Based On Different Molsupporting
confidence: 84%
“…Indeed, GSEA analysis confirmed this premise: lymph node metastasis was associated with number of pathways that include transcription factors of the NF-κB family which were previously associated with the lymph node metastasis of breast tumors [64]. On the other hand, distant metastasis was primarily connected to pathways regulating stronger mechanisms related to cell cycle and proliferation control, in agreement with Chowdhury et al [65]. Other key pathways related to distant metastasis involved fibrinolytic proteases including urokinase plasminogen activator (uPA), well known in term of distant metastasis in breast cancer [66].…”
Section: Lymph Node and Distant Metastasis Are Based On Different Molsupporting
confidence: 84%
“…Those four hub genes were enriched in extracellular matrix, especially in proteinaceous extracellular matrix. A recent study reported that extracellular matrix could play a vital role in breast cancer metastasis [ 11 ]. We could hypothesize that those four genes might contribute to the metastasis of gastric cancer,…”
Section: Discussionmentioning
confidence: 99%
“…We also found a subset of genes involved in signaling pathways upregulated in BM1 and BM2 cell sublines, such as mTOR signaling, Myc signaling, protein translation, peptide elongation, mRNA 3'UTR regulation, protein secretion, and cell surface protein targeting to cell membrane, which are consistent with literature that metastatic cancer cells not only showed activation of oncogenic signaling including c-myc/β-catenin signaling and PI3K/AKT/mTOR signaling 25 - 27 , but also showed high levels of secretary or cell surface proteins in expression 10 , involving in cell homing to bone, angiogenesis, invasion, and osteoclast recruitment 10 . Furthermore, based on analysis of multiple publicly available datasets, a positive association between the gene sets representing protein translation and metastasis in basal-like breast cancer has been reported 28 . As such, the posttranscriptional regulation and protein translation/secretion must be of help in synthesizing adequate metabolic enzymes and structural proteins in the cells undergoing EMT, invasion and metastasis.…”
Section: Discussionmentioning
confidence: 99%