Association of Psoriasis With Mental Health Disorders in South Korea

Bang, Chul Hwan; Yoon, Jae Woong; Chun, Jae Heon; Han, Ju Hee; Park, Young Min; Lee, Suk Jun; Lee, Ji Hyun

doi:10.1001/jamadermatol.2019.0315

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…A study exploring the association of psoriasis with mental health disorders in South Korea found that the risk of depressive episodes, anxiety disorders, somatoform disorders, neurotic disorders and non-organic sleep disorders was 2. 7 However, another study exploring psoriasis and the risk of mental disorders in Denmark found a heightened risk of BP among individuals with psoriasis (HR: 2.33 (95% CI: 1.59 to 3.41). 8 A primary care cohort study from the UK exploring psychiatric morbidities in psoriasis also found higher prevalence for histories of alcohol misuse, BP, depression, anxiety disorder and self-harm in patients with psoriasis.…”

Section: Discussionmentioning

confidence: 98%

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Uvais¹,

Rakhesh²,

Afra³

et al. 2020

Gen Psych

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Psoriasis is a chronic, immune mediated, systemic inflammatory skin disease with a reported prevalence of 0.6%–4.8% in the general population. Bipolar disorder (BP) is a severe episodic psychiatric disorder that ranks as the fourth leading cause of disability. Recent evidence suggests that genetic and immunological factors play a significant role in the development of both disorders. Studies have also shown a higher association of psychiatric disorders among patients with psoriasis. Moreover, several autoimmune comorbidities have been reported in association with BP. Here, we describe a young woman with BP who developed psoriasis after 1 year of developing BP and showed exacerbations in psoriasis lesions with each manic episode. We also highlight the safe and efficacious use of apremilast for psoriatic lesions in the woman.

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Section: Discussionmentioning

confidence: 98%

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Uvais¹,

Rakhesh²,

Afra³

et al. 2020

Gen Psych

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“…Our findings are in agreement with those of previous research. 12 However, current study design would more clearly demonstrate the causal relationship between psoriasis and psychiatric diseases as we conducted a prospective cohort study.…”

Section: Discussionmentioning

confidence: 99%

“…22 Another observational study in Korea also showed higher risk of anxiety disorders in patients with psoriasis than in control patients. 12 Psoriasis can be exacerbated by underlying psychiatric diseases like a vicious cycle, when psychiatric diseases worsen the skin disease. There is a biological interconnection between depression, anxiety, and psoriasis.…”

Section: Discussionmentioning

confidence: 99%

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Risk of psychiatric diseases among patients with psoriasis in Korea: A 12‐year nationwide population‐based cohort study

Kim

et al. 2021

The Journal of Dermatology

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The association between psoriasis and risk of psychiatric diseases has not been thoroughly evaluated in a large longitudinal cohort of the Asian population. We conducted a nationwide cohort study encompassing more than 1.6 million Koreans with a 12-year follow-up period. Patients were considered to be in the psoriasis cohort if they had an incident diagnostic code for psoriasis and included patients were followed up until they developed any psychiatric disease. In adjusted models, psoriasis patients (n = 10 868) were at an 18% increased risk for depression (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.09-1.26), 16% for anxiety disorders (HR, 1.16; 95% CI, 1.08-1.26), and 21% for somatoform disorders (HR, 1.21; 95% CI, 1.08-1.34) compared with the referent cohort (n = 1 620 055). Patients with moderate-to-severe psoriasis had a higher risk of developing depression and somatoform disorders than patient with mild disease (depression, HR,

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“…The prevalence per 10,000 people in Korea increased from 47.4 to 61.5 from 2006 to 2015, with a higher prevalence in men >30 years old [3]. Individuals with psoriasis are at an increased risk of developing other chronic and serious health diseases, including psoriatic arthritis (PsA) (pooled proportion 19.7%; 95% confidence interval [CI] 18.5%-20.9%) [4], type 2 diabetes mellitus (odds ratio [OR] 1.69; 95% CI 1.51-1.89), hypertension (OR 1.43; 95% CI 1.25-1.64) [5], and even depression (OR 2.19; 95% CI 1.97-2.44) [6]. Psoriasis is mainly a dendritic cell-and T-cell-mediated disease, with the production of tumor necrosis factor (TNF)-α and interleukin (IL)-17, 22, 23 [1].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis is Associated with An Increased Risk of Osteoporosis: Follow-Up and Nested Case–Control Studies Using A National Sample Cohort

Lee

Min

Bang

et al. 2020

Preprint

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Objectives: The aim of the present study was to evaluate the association between psoriasis and osteoporosis using two different studies. Methods: Data from the Korean National Health Insurance Service-Health Screening Cohort of participants who were ≥ 40 years old were collected from 2002 to 2013. Psoriasis and osteoporosis were included using ICD-10 codes. In study I (a follow-up study), a total of 25,306 psoriasis participants were matched to 101,224 controls with respect to age group, sex, income group, and region of residence, and the occurrence of osteoporosis was analyzed. Crude (simple) and adjusted hazard ratios (HRs) were analyzed using a stratified Cox proportional hazard model. In study II (a nested case–control study), a total of 79,212 osteoporosis patients were matched to 79,212 controls, and a previous history of psoriasis was analyzed. Crude and adjusted odds ratios (ORs) were analyzed using a conditional logistic regression analysis. Subgroup analyses were conducted according to age group and sex. Results: The adjusted HR of osteoporosis was 1.11 (95% confidence interval [CI] = 1.07-1.15, P < 0.001) in study I. In the subgroup analysis according to age and sex, the results were consistent except for the ≥ 60-year-old women. The adjusted OR of psoriasis was 1.22 (95% CI = 1.16-1.28, P < 0.001) in study II. All subgroups demonstrated high adjusted ORs of osteoporosis for psoriasis. Conclusions: Psoriasis increased the risk of osteoporosis in the population of participants aged ≥ 40 years in Korea.

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Association of Psoriasis With Mental Health Disorders in South Korea

Abstract: Nijsten T, Meads DM, de Korte J, et al. Cross-cultural inequivalence of dermatology-specific health-related quality of life instruments in psoriasis patients.

Cited by 14 publications

References 9 publications

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Risk of psychiatric diseases among patients with psoriasis in Korea: A 12‐year nationwide population‐based cohort study

<strong>Psoriasis is Associated with </strong><strong>An</strong><strong> Increased Risk of Osteoporosis: Follow</strong><strong>-</strong><strong>Up and Nested Case–Control Studies Using A National Sample Cohort</strong>

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Association of Psoriasis With Mental Health Disorders in South Korea

Abstract: Nijsten T, Meads DM, de Korte J, et al. Cross-cultural inequivalence of dermatology-specific health-related quality of life instruments in psoriasis patients.

Cited by 14 publications

References 9 publications

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Comorbid psoriasis-bipolar disorder successfully treated with apremilast: much more than a mere coincidence?

Risk of psychiatric diseases among patients with psoriasis in Korea: A 12‐year nationwide population‐based cohort study

<strong>Psoriasis is Associated with </strong><strong>An</strong><strong> Increased Risk of Osteoporosis: Follow</strong><strong>-</strong><strong>Up and Nested Case&ndash;Control Studies Using A National Sample Cohort</strong>

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<strong>Psoriasis is Associated with </strong><strong>An</strong><strong> Increased Risk of Osteoporosis: Follow</strong><strong>-</strong><strong>Up and Nested Case–Control Studies Using A National Sample Cohort</strong>