Association of puberty timing with type 2 diabetes: A systematic review and meta-analysis

Cheng, Tuck Seng; Day, Felix R.; Lakshman, Rajalakshmi; Ong, Ken K.

doi:10.1371/journal.pmed.1003017

Cited by 64 publications

(55 citation statements)

References 60 publications

(199 reference statements)

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“…Global secular trends towards earlier timing of puberty [1,2] represent an increasingly important public health issue. Substantial evidence has demonstrated that an earlier timing of puberty is associated with poorer mental and physical health in later life [3][4][5][6][7]. While the underlying mechanisms remain unclear, greater childhood growth and obesity have been associated with both earlier puberty [8] and adverse health outcomes [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses

et al. 2021

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Dietary intakes of polyunsaturated, monounsaturated and saturated fatty acids (FAs) have been inconsistently associated with puberty timing. We examined longitudinal associations of prepubertal dietary and plasma phospholipid FAs with several puberty timing traits in boys and girls. In the Avon Longitudinal Study of Parents and Children, prepubertal fat intakes at 3–7.5 years and plasma phospholipid FAs at 7.5 years were measured. Timings of Tanner stage 2 genital or breast development and voice breaking or menarche from repeated reports at 8–17 years, and age at peak height velocity (PHV) from repeated height measurements at 5–20 years were estimated. In linear regression models with adjustment for maternal and infant characteristics, dietary substitution of polyunsaturated FAs for saturated FAs, and higher concentrations of dihomo-γ-linolenic acid (20:3n6) and palmitoleic acid (16:1n7) were associated with earlier timing of puberty traits in girls (n = 3872) but not boys (n = 3654). In Mendelian Randomization models, higher genetically predicted circulating dihomo-γ-linolenic acid was associated with earlier menarche in girls. Based on repeated dietary intake data, objectively measured FAs and genetic causal inference, these findings suggest that dietary and endogenous metabolic pathways that increase plasma dihomo-γ-linolenic acid, an intermediate metabolite of n-6 polyunsaturated FAs, may promote earlier puberty timing in girls.

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Section: Introductionmentioning

confidence: 99%

Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses

et al. 2021

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“…These findings have become a matter of intense debate and concern due to the association of earlier ages at puberty with increased prevalence of childhood obesity and adverse consequences in adult life ( Ahmed et al., 2009 ; Biro et al., 2006 ; Burt Solorzano and McCartney, 2010 ; Ong et al., 2006 ; Shalitin and Kiess, 2017 ; Walvoord, 2010 ). Premature pubertal development in girls is associated with a series of adult morbidities including breast cancer, cardiovascular diseases, type 2 diabetes, and obesity ( Berkey et al., 1999 ; Cheng et al., 2020 ; Day et al., 2015 , 2017 ; Lakshman et al., 2008 ; Petridou et al., 1996 ; Petry et al., 2018 ). The molecular mechanisms and the cross talk between metabolism and pubertal development are not fully understood, but tissue- and/or cell-specific genome-wide association studies (GTEx, GWAS projects) have identified the brain as the main site of genetic enrichment of transcripts with roles in age at menarche and/or obesity susceptibility ( Day et al., 2017 ; Locke et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice

et al. 2020

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Summary Epidemiological and genome-wide association studies (GWAS) have shown high correlation between childhood obesity and advance in puberty. Early age at menarche is associated with a series of morbidities, including breast cancer, cardiovascular diseases, type 2 diabetes, and obesity. The adipocyte hormone leptin signals the amount of fat stores to the neuroendocrine reproductive axis via direct actions in the brain. Using mouse genetics, we and others have identified the hypothalamic ventral premammillary nucleus (PMv) and the agouti-related protein (AgRP) neurons in the arcuate nucleus (Arc) as primary targets of leptin action in pubertal maturation. However, the molecular mechanisms underlying leptin's effects remain unknown. Here we assessed changes in the PMv and Arc transcriptional program during leptin-stimulated and typical pubertal development using overlapping analysis of bulk RNA sequecing, TRAP sequencing, and the published database. Our findings demonstrate that dynamic somatodendritic remodeling and extracellular space organization underlie leptin-induced and typical pubertal maturation in female mice.

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“…The age when an adolescent girl first begins menses affects their sexual and reproductive health as well as non-reproductive health [ 4 ]. Earlier age at menarche has been associated with a higher risk of metabolic syndrome [ 5 , 6 ], type 2 diabetes [ 7 , 8 ], hormone-related cancers [ 9 , 10 ], cardiovascular disease, and mortality later in life during adulthood [ 11 ]. In Iranian women, the risk of pre-diabetes, diabetes, and metabolic syndrome was 2.3–3.6 higher in women with menarcheal age < 11 than those with menarcheal age 13–14 years [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…In Iranian women, the risk of pre-diabetes, diabetes, and metabolic syndrome was 2.3–3.6 higher in women with menarcheal age < 11 than those with menarcheal age 13–14 years [ 6 , 8 ]. It has also been estimated that the risk of type 2 diabetes is reduced by 9% per 1-year later occurrence of menarche [ 7 ], and the risk of metabolic syndrome is increased by 8% per 1-year decrease in AAM [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal association of dietary sources of animal and plant protein throughout childhood with menarche

et al. 2021

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Background Inconsistent findings have been reported for associations between protein intake and age at menarche. We aimed to investigate the association between intake of protein and protein-containing food groups during childhood with menarche among Iranian girls. Methods Girls aged 6–18 years who did not experience menarche in the third or fourth examination cycles of the Tehran Lipid and Glucose Study were selected and were followed to the fifth examination cycle. Daily intakes of protein from different animal/plant sources and ten protein-containing food groups were assessed using a food frequency questionnaire at baseline (the third or fourth examination cycles). Occurrence of menarche and its onset age were asked during each examination cycle. Cox proportional hazards regression was used to estimating hazard ratios (HRs) and 95% confidence interval (95%CI) for the occurrence of menarche per one standard deviation (SD) of dietary intakes. Logistic regression was also used to estimate the odds of reaching menarche ≤12 years. Results During the study, 147(61%) of girls reached menarche, the median age at menarche was 12 years. The adjusted HRs (95% CI) for the occurrence of menarche per one-SD of dietary intakes were 0.68 (0.48, 0.98; p = 0.040) for plant protein and 1.36 (1.01, 1.84; p = 0.042) for animal protein after adjusting for baseline age, BMI Z-score, energy intake, and mother’s early menarche and education. Substituting 10-g animal protein with plant protein was associated with a 16% (95%CI: 5–25%; p = 0.006) lower risk of menarche. Dietary intakes of poultry (adjusted HR: 1.35; 95% CIs: 1.00–1.82; p = 0.049) and low-fat dairy (adjusted HR: 1.20; 95%CIs: 0.99–1.46; p = 0.064) were marginally associated with the increased risk of menarche. However, the odds of early menarche was significant only for plant protein (adjusted odds ratio = 0.39; 95% CI: 0.16–0.96; p = 0.040). Conclusions Our findings indicate that the risk of menarche increases by higher intakes of animal protein and decreases by plant protein. Intakes of poultry and low-fat dairy associate with a higher risk of menarche. The odds of menarche occurrence ≤12 years reduces by higher intakes of plant protein.

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Association of puberty timing with type 2 diabetes: A systematic review and meta-analysis

Cited by 64 publications

References 60 publications

Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses

Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses

Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice

Longitudinal association of dietary sources of animal and plant protein throughout childhood with menarche

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