“…In the short term, children in substitute care tend to perform less well academically, 11,12 are more prone to permanent school exclusion, 13 are more likely to engage in illicit drug taking, 14 and have a higher prevalence of a range of psychiatric disorders, than their unexposed peers. 15 As looked-after children transition to independent living in early adulthood, there is a suggestion that mental health problems continue, 13,16,17 in addition to there being an increased likelihood of socioeconomic disadvantage, 17,18 homelessness, 19 and engagement in harmful health behaviours. 17,20 The burden of risk ascribed to these unfavourable characteristics raises the possibility that exposure to state care in childhood might be associated with an elevated occurrence of physical health problems later in the life course, most obviously in terms of total mortality, cardiovascular disease, and selected cancers.…”