Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study

Wu, Chunlei; Ma, Denhua; Chen, Yu

doi:10.2147/ijgm.s327841

Cited by 6 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[30][31][32] In a retrospective study involving 211 814 Chinese participants, after controlling for BMI, smoking and drinking status, age, TC, gender, family history of diabetes, FPG, TG and BUN and ALT, Higher PP levels independently connect with increased T2DM risk (HR :1.003, 95%CI 1.001 to 1.005). 11 In a longitudinal study involving 12 272 Chinese, Zhang et al 30 found that high PP in Chinese women may be related to the development of T2DM after adjusting for confounding covariates. In a national cross-sectional study involving 6187 Korean older adults, Kwon et al 32 discovered a positive association between PP and metabolic syndrome after adjusting for alcohol consumption, smoking, age, regular exercise and mean arterial blood pressure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study

Cao,

Han,

et al. 2024

BMJ Open

View full text Add to dashboard Cite

ObjectivePrevious research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incident pre-DM in a substantial cohort of Chinese participants.DesignThe ‘DATADRYAD’ database (www.Datadryad.org) was used to retrieve the data for this secondary retrospective cohort analysis.ParticipantsData from 182 672 Chinese individuals who participated in the medical examination programme were recorded in this retrospective cohort study between 2010 and 2016 across 32 sites and 11 cities in China.SettingPP assessed at baseline and incident pre-DM during follow-up were the target-independent and dependent variables. The association between PP and pre-DM was investigated using Cox proportional hazards regression.Primary outcome measuresThe outcome was incident pre-DM. Impaired fasting glucose levels (fasting blood glucose between 5.6 and 6.9 mmol/L) were used to define pre-DM.ResultsAfter controlling for confounding variables, PP was positively correlated with incident pre-DM among Chinese adults (HR 1.009, 95% CI 1.007 to 1.010). Additionally, at a PP inflection point of 29 mm Hg, a non-linear connection between the PP and incident pre-DM was discovered. Increased PP was an independent risk factor for developing pre-DM when PP was greater than 29 mm Hg. However, their association was not significant when PP was less than 29 mm Hg. According to subgroup analyses, females, never-smokers and non-obesity correlated more significantly with PP and pre-DM.ConclusionWe discovered that higher PP independently correlated with pre-DM risk in this study of Chinese participants. The connection between PP and incident pre-DM was also non-linear. High PP levels were related to a higher risk of pre-DM when PP was above 29 mm Hg.Article focusOur study investigated the relationship between PP and incident pre-DM in a secondary retrospective cohort of Chinese participants.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 10 PP was found to be a significant risk factor for T2DM in a recent retrospective cohort investigation of a sizeable sample. 11 However, whether pre-DM in Chinese adults is associated with PP is unknown. This study sought to analyse the precise correlation between PP and the likelihood of developing pre-DM in Chinese participants.…”

Section: Introductionmentioning

confidence: 99%

Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study

Cao,

Han,

et al. 2024

BMJ Open

View full text Add to dashboard Cite

show abstract

“…We did not find a significant association of E-selectin with pulse pressure during daytime, nighttime and 24 h periods. High values of pulse pressure indicate elevated arterial stiffness, a feature frequently found in persons with diabetes [ 56 ] and hypertension [ 57 ]. However, the physiological mechanisms explaining the increase in pulse pressure in persons with diabetes are yet to be identified.…”

Section: Discussionmentioning

confidence: 99%

E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes

et al. 2022

View full text Add to dashboard Cite

E-selectin is an endothelial cell adhesion molecule involved in vascular inflammation. Elevated E-selectin has been reported in patients with high blood pressure and diabetes. Given the increasing clinical relevance of parameters derived from ambulatory blood pressure monitoring, further investigation of their relationships with E-selectin is of interest. In this study, we aimed to investigate the association between serum E-selectin, office blood pressure and 24 h ambulatory blood pressure parameters in patients with type 2 diabetes. Blood pressure variability was assessed by computing the standard deviation of mean systolic and diastolic blood pressure separately for daytime and nighttime during 24 h ambulatory blood pressure monitoring in a cohort of patients with type 2 diabetes (n = 132). Additionally, were assessed nighttime systolic dipping and pulse pressure separately for daytime, nighttime, and 24 h. Serum E-selectin was measured using the enzyme-linked immunosorbent assay technique. We found that E-selectin was consistently associated with 24 h diastolic blood pressure variability (r = 0.238; p = 0.019) and daytime diastolic blood pressure variability (r = 0.258; p = 0.012), after adjustment for confounding factors. No association of E-selectin with office blood pressure and other 24 h ambulatory blood pressure parameters was observed. In conclusion, endothelial activation indicated by elevated serum E-selectin is associated with increased ambulatory diastolic blood pressure variability in patients with type 2 diabetes.

show abstract

“…Participants were classified as patients with T2DM if they had FPG ≥ 7.00 mmol/L or self-reported T2DM diagnosis during the follow-up period. [ 23 , 25 , 26 ] Participants’ data were reviewed by the medical staff either on the day of T2DM diagnosis or during their last visit.…”

Section: Methodsmentioning

confidence: 99%

Association of blood urea nitrogen to creatinine ratio with incident type 2 diabetes mellitus: A retrospective cohort study in the Chinese population

Yin,

Wang,

Jiang

et al. 2024

Medicine

View full text Add to dashboard Cite

Renal dysfunction can lead to insulin resistance and increase the incidence of type 2 diabetes mellitus (T2DM). The blood urea nitrogen to creatinine ratio (NCR) is a frequently used indicator to assess renal dysfunction and differentiate between prerenal and intrinsic renal injury. However, the association between NCR and T2DM in the Chinese population remains unclear. Hence, this study aimed to investigate the association between NCR and the incidence of T2DM in the Chinese population. The relationship between NCR and T2DM was examined using the Cox proportional hazards model and curve fitting techniques. In addition, a comprehensive set of sensitivity and subgroup analyses were performed. All results were presented as hazard ratios (HRs) and 95% confidence intervals (CIs). Between 2010 and 2016, 189,416 Chinese people were recruited from the Rich Healthcare Group for this retrospective cohort study. Of the participants, 3755 (19.8%) were diagnosed with T2DM during the follow-up period. After full adjustment, the Cox proportional hazards model revealed a positive connection between NCR and the incidence of T2DM (HR = 1.03, 95% CI: 1.02–1.04, P < .001). Compared with individuals with lower NCR Q1 (≤13.536), the multivariate HR for NCR and T2DM in Q2 (13.536–16.256), Q3 (16.256–19.638), Q4 (>19.638) were 1.08 (0.98–1.19), 1.16 (1.05–1.28), 1.39 (1.26–1.53). The higher NCR groups (≥20) had a higher ratio of T2DM (HR = 1.28, 95% CI: 1.18–1.38, P < .001) than the lowest NCR group (<20). These findings were validated using sensitivity and subgroup analyses. In conclusion, this study found a positive and independent association between NCR and the incidence of T2DM after adjusting for confounding variables.

show abstract

Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study

Cited by 6 publications

References 39 publications

Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study

Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study

E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes

Association of blood urea nitrogen to creatinine ratio with incident type 2 diabetes mellitus: A retrospective cohort study in the Chinese population

Contact Info

Product

Resources

About