Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross‐sectional pediatric chronic kidney disease cohort from the CKiD study

Raina, Rupesh; Polaconda, Shyam R.; Nair, Nikhil; Chakraborty, Ronith; Sethi, Sidharth Kumar; Krishnappa, Vinod; Kapur, Gaurav; Mhanna, Maroun J.; Kusumi, Kirsten

doi:10.1111/jch.13905

Cited by 9 publications

(6 citation statements)

References 33 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CKD is associated with increased risks of all‐cause mortality, cardiovascular disease, and progression to kidney failure 20,21 . In a cross‐sectional pediatric chronic kidney disease cohort from the CKiD study, they found that the pulse pressure was associated with lower eGFR in pediatric CKD patients 22 . A community‐based cohort study included 1426 participants, followed for a median of 4.8 years and found that central pulse pressure is an independent determinant of renal function 23 .…”

Section: Discussionmentioning

confidence: 99%

“… 20 , 21 In a cross‐sectional pediatric chronic kidney disease cohort from the CKiD study, they found that the pulse pressure was associated with lower eGFR in pediatric CKD patients. 22 A community‐based cohort study included 1426 participants, followed for a median of 4.8 years and found that central pulse pressure is an independent determinant of renal function. 23 And previous study have demonstrated that high resting heart rate is a potent predictor of renal outcomes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of pulsatile stress in childhood with subclinical renal damage in adults: A 30‐year prospective cohort study

Liao

Chu

Wang

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

The pulsatile stress in the microcirculation may contribute to development or progression of chronic kidney disease. However, there is no prospective data confirming whether pulsatile stress in early life affect renal function in middle age. The authors performed a longitudinal analysis of 1738 participants aged 6-15 years at baseline, an ongoing Adolescent Prospective Cohort with a follow-up of 30 years. The authors evaluated the association between pulsatile stress in childhood and adult subclinical renal damage (SRD), adjusting for related covariates. Pulsatile stress was calculated as resting heart rate × pulse pressure. Renal function was assessed with estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (uACR). The results showed that pulsatile stress in childhood was associated with adult SRD (Relative Risk, 1.43; p = .032), and the predictive value of combined pulse pressure and heart rate for SRD was higher than either of them alone. The high pulsatile stress in childhood increased the risk of adult SRD in males (RR, 1.92; p = .003), but this association was not found in females (RR, 0.91; p = .729). Further, the participants were categorized into four groups on the basis of pulsatile stress status in childhood and adulthood. Male patients with high pulsatile stress during childhood but normal pulsatile stress as adults still had an increased risk of SRD (RR, 2.04; 95% CI, 1.18-3.54), while female patients did not (RR, 0.96; 95% CI, 0.46-1.99). The study demonstrated that high pulsatile stress in childhood significantly increased the risk of adult SRD, especially in males. Adequate control of pulse pressure and heart rate from childhood, in the long-term, is very important for preventing kidney damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of pulsatile stress in childhood with subclinical renal damage in adults: A 30‐year prospective cohort study

Liao

Chu

Wang

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…Similarly, the National Institute of Diabetes and Digestive Kidney Diseases registry in the US demonstrated that PP significantly correlated to the decline of GFR levels. (22) Additionally, one related cohort study found that among patients with CKD in stages IV and V, PP more than 80 mmHg constituted a significant predictor for disease progression. (23) PP was identified as a strong independent predictor of rising ambulatory arterial stiffness index.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Associated Factors in the Decline of Renal Function Among Outpatients Attending a Community Hospital, Central Thailand

Chamnanmont¹,

Chaiyakham²,

Kaensingh³

et al. 2021

J Southeast Asian Med Res

View full text Add to dashboard Cite

Introduction: Chronic kidney disease (CKD) is recognized as global public health issue especially affecting developing countries including Thailand. The epidemiologic data in the decline of renal function and the risk factors among Thai patients especially in community hospital settings were limited. Methods: A cross-sectional study was conducted to identify the prevalence and associated risk factors in the decline of renal function among outpatients in Thaluang Community Hospital, Lop Buri Province, central Thailand, between November 1, 2018 and October 31, 2019. The decline in renal function was defined by glomerular filtration rate (GFR) <60 mL/min/1.73m2. Multivariate logistic regression analysis was performed to obtain the adjusted odds ratios (AOR) and 95% confidence interval (CI) of the factors related to the decline of renal function. Results: A total of 874 outpatients participated in the study. The overall prevalence in the decline of renal function (eGFR <60 mL/min/1.73m2) was 20.3% (95% CI; 17.5%-22.9%). Among male participants, the prevalence in the decline of renal function was 21.1% (95%CI; 16.7%-25.5%) while it totaled 19.7% (95%CI; 16.3%-23.1%) among females. The independent associated factors in the decline of renal function included greater age (AOR 1.07; 95% CI=1.05-1.09), history of NSAIDs used (AOR 2.97; 95% CI=1.85-4.79) and elevated pulse pressure (PP) >75th percentile (AOR 1.64; 95% CI=1.07-2.53) Conclusion: We reported the prevalence in the decline of renal function among outpatients in a Thai community hospital which was comparable with the national level. Advanced age, history of NSAIDs used and PP were related to reduced kidney function. Therefore, effective health interventions should be conducted especially, appropriate NSAIDs used among outpatients.

show abstract

“…The AASI was defined as 1 minus the regression slope. Prior research in pediatric CKD indicated that elevated AASI is linked to high BP [ 55 , 56 ].…”

Section: Cardiovascular Risks and Biomarkers In Pediatric Ckdmentioning

confidence: 99%

Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease

Tain

Hsu²

2022

Children

View full text Add to dashboard Cite

Hypertension is the most common complication of chronic kidney disease (CKD) in children, having a strong association with subsequential cardiovascular disease (CVD). In pediatric CKD, a considerable percentage of children with hypertension are undiagnosed or undertreated. Prior research has evaluated structural and functional markers of subclinical CVD and biomarkers in adults with CKD, while ideal biomarkers in pediatrics are still insufficiently studied. The ultimate goal of this review is to summarize what is currently known about state of hypertension, cardiovascular risk factors, and potential CVD markers/biomarkers in children with pre-dialysis CKD. We discuss omics-related biomarkers and the pathophysiologic processes of endothelial dysfunction, kidney injury, oxidative stress and inflammation that are classified by specific biomarkers. Moreover, we illustrate the existing challenges and highlight the paucity of pediatric CKD research to evaluate these CVD biomarkers for future clinical pediatric practice. Thus, achieving clinical utility of CVD biomarkers for use in pediatric CKD remains a significant challenge requiring additional efforts.

show abstract

Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross‐sectional pediatric chronic kidney disease cohort from the CKiD study

Cited by 9 publications

References 33 publications

Association of pulsatile stress in childhood with subclinical renal damage in adults: A 30‐year prospective cohort study

Association of pulsatile stress in childhood with subclinical renal damage in adults: A 30‐year prospective cohort study

Prevalence and Associated Factors in the Decline of Renal Function Among Outpatients Attending a Community Hospital, Central Thailand

Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease

Contact Info

Product

Resources

About