2021
DOI: 10.1007/s10067-021-05918-x
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Association of quantitative computed tomography ındices with lung function and extent of pulmonary fibrosis in patients with systemic sclerosis

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Cited by 5 publications
(9 citation statements)
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“…It was also shown that, even in the absence of signs of pulmonary fibrosis on HRCT, lung density was higher in patients with dcSSc compared with both lcSSc patients and HCs (67). Furthermore, they reported that qCT parameters differentiated SSc patients with ILD showing a good correlation with visual fibrosis scores (68). Carnevale et al showed that repeated HRCT after 12-24 months seemed useful for the longitudinal characterization of ILD evolution in patients with stable pulmonary function.…”
Section: Pulmonary Involvementmentioning
confidence: 99%
“…It was also shown that, even in the absence of signs of pulmonary fibrosis on HRCT, lung density was higher in patients with dcSSc compared with both lcSSc patients and HCs (67). Furthermore, they reported that qCT parameters differentiated SSc patients with ILD showing a good correlation with visual fibrosis scores (68). Carnevale et al showed that repeated HRCT after 12-24 months seemed useful for the longitudinal characterization of ILD evolution in patients with stable pulmonary function.…”
Section: Pulmonary Involvementmentioning
confidence: 99%
“…Conversely, some patients may present with severe and/or rapidly progressive ILD and for this reason, many efforts have been made to identify patients at risk for ILD and its greater severity. Among these were the dcSSc subset, African-American race, older age and disease onset, shorter disease duration, positive abs anti-Mouse I, and absence of ACA [86][87][88][89][90][91][92][93][94].…”
Section: Biomarkers In Systemic Sclerosis Interstitial Lung Diseasementioning
confidence: 99%
“…Lung endothelial damage is central to the pathogenesis of ILD. Histologically, SSc-ILD presents as a picture of nonspecific interstitial pneumonia, unlike idiopathic pulmonary fibrosis, which is usually characterized by the usual picture of interstitial pneumonia [93][94][95][96][97][98]. SSc-ILD is characterized by inflammation early in the disease, extensive endothelial dysfunction, and increased deposition of ECM, particularly collagen produced by activated myofibroblasts in resident tissues [79][80][81][82][83][84][85][86][87].…”
Section: Biomarkers In Systemic Sclerosis Interstitial Lung Diseasementioning
confidence: 99%
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“…Postprocessing analysis was performed with dedicated software (CT Lung Density Analysis, Vitrea Advance Visualization, Canon) [51]. Notably, an automated segmentation of lung tissues with quantifiable controls and renderings is performed by the software.…”
Section: Postprocessing Analysismentioning
confidence: 99%