Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The rotterdam study

Burger, Huibert; Daele, P. L. A. Van; Odding, Else; Valkenburg, H. A.; Hofman, Albert; Grobbee, Diederick E.; Schütte, H; Birkenhäger, J. C.; Pols, Huibert A. P.

doi:10.1002/art.1780390111

Cited by 233 publications

(196 citation statements)

References 24 publications

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“…The Rotterdam Study [23] showed that BMD was higher in patients with OA and the rate of bone loss was increased in men and women with OA of the knee and the hips; moreover, the age-related bone loss ratio was increased in older patients, suggesting a more pronounced difference in BMD earlier in the life. These findings suggest the presence of metabolic factors that may play an important role in BMD and bone loss ratio.…”

Section: Discussionmentioning

confidence: 99%

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Franco

Mauceri

Scavalli

et al. 2000

Clinical Rheumatology

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Diffuse idiopathic skeletal hyperostosis (DISH) is an ossifying systemic enthesopathy which involves not only the spine but which may also appear in other sites. Degenerative, inflammatory and metabolic factors have been reported for a possible pathogenic role in the new bone growth that characterises DISH. In the present study peripheral bone mineral density (BMD) has been measured in patients affected by DISH and the results compared to those of a control group. Forty-two patients (33 females and 9 males) affected by DISH and 84 controls (66 females and 18 males) were examined. All subjects underwent radiological study of the lumbar and dorsal spine and the pelvis. BMD was evaluated using dual-energy X-ray absorptiometry and the examination was performed in the distal radius. In DISH patients the mean value of BMD was significantly higher than in controls (P50.002), even when it was referred to sex subgroups. Statistical analysis showed significant differences between both the two male groups (P50.002) and the two female groups (P50.01). In the two female subgroups (DISH patients and controls) BMD was significantly inversely related to age and to the duration of the postmenopausal period. The present study showed higher BMD in DISH patients than in the control group.

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Section: Discussionmentioning

confidence: 99%

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Franco

Mauceri

Scavalli

et al. 2000

Clinical Rheumatology

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“…After removing 56 duplicate studies, a total of 386 studies were identified, of which 356 were deemed irrelevant, 16 were deemed relevant [1, 3, 9, 26-31, 36, 43, 44, 47-49, 55], and 14 were of uncertain relevance [4-6, 8, 12, 16, 17, 19, 24, 25, 32, 45, 52, 53]. On further evaluation of the full-text article for the latter group, only two of the 14 were deemed relevant [5,19]. We excluded studies on full-text screening for a number of reasons (see Appendix 1).…”

Section: Methodsmentioning

confidence: 99%

“…An additional five studies [7,22,23,38,54] were identified from reference lists of included studies. The 23 studies included 13 cross-sectional studies [1, 7, 9, 19, 23, 27-31, 43, 54, 55], six cohort studies [5,22,44,[47][48][49], one case-control study [3], and three previous review articles on this topic [26,36,38]. Older estimates of the prevalence of radiographic primary hip OA reported in the latter group were used to supplement those uncovered by our electronic search.…”

Section: Methodsmentioning

confidence: 99%

“…The most common method used to diagnose overall prevalence of radiographic primary hip OA was that of Kellgren and Lawrence (K&L) (n = 23) [5,19,23,26,27,29,33,37,38,43,44,[47][48][49]54] followed by minimum joint space width (JSW) (n = 10) [3,9,26,28,30,43,49] and other classification schemes such as the Croft index (n = 2) [55], the American College of Rheumatology criteria (n = 1) [1], the Atlas of Osteoarthritis criteria (n = 1) [38], and unspecified methods (n = 2) [26]. The CV for the K&L method of diagnosis was 97.4% for K&L Grade C 2 and 73.1% for K&L C 3; the Croft C 3 method of diagnosis had a CV of 113.6%.…”

Section: Prevalence By Methods Of Diagnosismentioning

confidence: 99%

“…The methodological quality score for the 19 estimates of the prevalence of radiographic hip OA reported in the 16 primary studies [1, 3, 5, 7, 9, 19, 23, 27-30, 43, 44, 47, 54, 55] (three of which [29,43,55] reported on two separate cohorts each) uncovered in this review had a mean of 4.9 with a standard deviation of 0.9, a median of 5.0, and a range from 3.0 to 7.0 (Table 9). Only five of these estimates from four studies [9,[27][28][29] were considered of lower methodological quality (ie, score of 4 or lower), whereas 14 estimates from 12 studies [1,3,5,7,19,23,30,43,44,47,54,55] were considered of higher methodological quality (ie, score of 5 or higher). The mean prevalence reported in studies of lower methodological quality was 5.9% with a standard deviation of 4.0% and a median of 5.3% compared with a mean of 7.4%, a standard deviation of 6.4%, and a median of 6.7% for studies of higher methodological quality.…”

Section: Prevalence By Study Methodological Qualitymentioning

confidence: 99%

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Systematic Review of the Prevalence of Radiographic Primary Hip Osteoarthritis

Dagenais

Garbedian

Wai

2009

Clinical Orthopaedics &Amp; Related Research

180

124

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Hip osteoarthritis is a common cause of musculoskeletal pain in older adults and may result in decreased mobility and quality of life. Although the presentation of hip osteoarthritis varies, surgical management is required when the disease is severe, longstanding, and unresponsive to nonoperative treatments. For stakeholders to plan for the expected increased demand for surgical procedures related to hip osteoarthritis, including arthroplasty, it is important to first understand its prevalence. We conducted a systematic review by searching MEDLINE1 and EMBASE to identify recent English language articles reporting on the prevalence of radiographic primary hip osteoarthritis in the general adult population; references including studies and primary studies from previous systematic reviews were also searched. This strategy yielded 23 studies reporting 39 estimates of overall prevalence ranging from 0.9% to 27% with a mean of 8.0% and a standard deviation of 7.0%. Heterogeneity was noted in study populations, eligibility criteria, age and gender distribution, type of radiographs, and method of diagnosis. Although the association between radiographic hip osteoarthritis and the need for eventual surgical management is still unclear, this study supports assertions that hip osteoarthritis is a prevalent condition whose treatment will continue to place important demands on health services.

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The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women

Sowers

Lachance

Jamadar

et al. 1999

Arthritis & Rheumatism

148

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Objective. To determine whether Caucasian women ages 28-48 years with newly defined osteoarthri-tis (OA) would have greater bone mineral density (BMD) and less bone turnover over time than would women without OA. Methods. Data were derived from the longitudinal Michigan Bone Health Study. Period prevalence and 3-year incidence of OA were based on radiographs of the dominant hand and both knees, scored with the Kellgren/Lawrence (K/L) scale. OA scores were related to BMD, which was measured by dual-energy x-ray absorptiometry, and to serum osteocalcin levels, which were measured by radioimmunoassay. Results. The period prevalence of OA (K/L grade >2 in the knees or the dominant hand) was 15.3% (92 of 601), with 8.7% for the knees and 6.7% for the hand. The 3-year incidence of knee OA was 1.9% (9 of 482) and of hand OA was 3.3% (16 of 482). Women with incident knee OA had greater average BMD (z-scores 0.3-0.8 higher for the 3 BMD sites) than women without knee OA (P < 0.04 at the femoral neck). Women with incident knee OA had less change in their average BMD z-scores over the 3-year study period. Average BMD z-scores for women with prevalent knee OA were greater (0.4-0.7 higher) than for women without knee OA (P < 0.002 at all sites). There was no difference in average BMD z-scores or their change in women with and without hand OA. Average serum osteocalcin levels were lower in incident cases of hand OA (>60%; P 0.02) or knee OA (20%; P not significant). The average change in absolute serum osteocalcin levels was not as great in women with incident hand OA or knee OA as in women without OA (P < 0.02 and P < 0.05, respectively). Conclusion. Women with radiographically defined knee OA have greater BMD than do women without knee OA and are less likely to lose that higher level of BMD. There was less bone turnover among women with hand OA and/or knee OA. These findings suggest that bone-forming cells might show a differential response in OA of the hand and knee, and may suggest a different pathogenesis of hand OA and knee OA. Osteoarthritis (OA) is a major chronic disease. It has been estimated to affect 1 in 10 people at age 50 and 1 in 2 people at age 75 (1). Likewise, osteoporosis (OP) is a highly prevalent condition that has been estimated to affect 1 woman in 5 by age 80 (2). Thus, OP and OA are both common conditions that are more likely to affect women than men. It is relatively unusual, however, to find both conditions in the same individual. Early clinical comparisons showed that elderly persons undergoing resection of the femoral head to treat hip OA were much less likely to have evidence of bone loss than were elderly persons who had femoral neck fractures (3). Subsequent studies indicated that persons with OA of the knee or hip were more likely to have higher bone mass than normal subjects or subjects with OP (4-6), whereas patients with OA of the hand might not have greater bone mass (7-9). This suggests either a difference in the pathogenesis of hand and knee OA or a possible measurement artifact. (Great...

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Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The rotterdam study

Cited by 233 publications

References 24 publications

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Systematic Review of the Prevalence of Radiographic Primary Hip Osteoarthritis

The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women

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