2023
DOI: 10.1097/cej.0000000000000837
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Association of radiotherapy for stage I–III breast cancer survivors and second primary malignant cancers: a population-based study

Jin Shi,
Jian Liu,
Guo Tian
et al.

Abstract: Purpose: With life span extending, breast cancer survivors may face the possibility of developing second primary cancers (SPCs). The objective of this research is to investigate the risk factors, risk attribute to radiotherapy and the survivalship for SPCs. Methods: A total of 445 523 breast cancer patients were enrolled from Surveillance, Epidemiology, and End Results database in 2000–2018. The risk factors for SPCs development were confirmed by compet… Show more

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“…Radiation-induced cancer is classically defined as a stochastic process, although recent studies developed more complex models; therefore, there is no threshold point and even low doses may increase second neoplasms risk. This phenomenon is relevant especially for long-term survivors and has been extensively investigated for lymphoma and breast cancer patients, mostly focusing on second lung, breast and thyroid malignancies [29][30][31]. Nonetheless, some studies defined the risk of secondary liver cancer after breast irradiation, with conflicting results: while in some models, the lifetime attributable risk (LAR) for liver cancer induction after breast radiotherapy was extremely low [32], in other experiences high LAR estimates were obtained for liver in case of right-sided targets [33].…”
Section: Discussionmentioning
confidence: 99%
“…Radiation-induced cancer is classically defined as a stochastic process, although recent studies developed more complex models; therefore, there is no threshold point and even low doses may increase second neoplasms risk. This phenomenon is relevant especially for long-term survivors and has been extensively investigated for lymphoma and breast cancer patients, mostly focusing on second lung, breast and thyroid malignancies [29][30][31]. Nonetheless, some studies defined the risk of secondary liver cancer after breast irradiation, with conflicting results: while in some models, the lifetime attributable risk (LAR) for liver cancer induction after breast radiotherapy was extremely low [32], in other experiences high LAR estimates were obtained for liver in case of right-sided targets [33].…”
Section: Discussionmentioning
confidence: 99%