Association of recreational physical activity with homocysteine, folate and lipid markers in young women

Abstract

We assessed the influence of recreational physical activity in young healthy women on homocysteine, a potential risk factor for cardiovascular disease (CVD). Participants were 124 23-year-old normal-weight Italian recreational athletes (performing 8.7 +/- 2.46 h week(-1) exercise) and 116 controls. Median blood homocysteine, folate and lipid markers did not differ between athletes and controls. Elevated homocysteine levels at CVD risk > or =12.0 and > or =15.0 micromol l(-1) were not different between groups. Continuous homocysteine was inversely related to folate (P < 0.001), positively associated with age (P = 0.009) and creatinine (P = 0.033), but not associated with hours of exercise, body mass index, and lipid markers. Women with folate depletion (<3.0 microg l(-1)) were 4.5-fold more likely to have homocysteine > or =15.0 micromol l(-1). Recreational physical exercise does not adversely impact homocysteine levels among young women. Only low folate significantly increases the risk for hyperhomocysteinemia in young women.

Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks

“…This might be indicating a change of dietary status. However; the folic acid level is declared as the main factor that can affect Hcy metabolism in great number of the researches [11,[15][16][17]19,21,23]. Our results supported these findings.…”

“…It was thought that the alterations of the creatine synthesis might change the Hcy levels due to formation of S-adenosylhomocysteine (the precursor of Hcy) from S-adenosylmethionine enhanced by high creatine synthesis [11]. Further; physical activity influences plasma protein metabolism and turnover and the concentration of amino acids such as methionine [1,16]. An increase in methyl group turnover increases Hcy production.…”

“…Homocysteine is a metabolic product of methionine [5,[7][8][9][10] and its metabolism has two pathways which requires folate+vitamin B 12 and vitamin B 6 [11]. For the last 20 years hyperhomocysteinemia (blood Hcy concentration equal or higher than 16 μmol/L) is a commonly accepted independent risk factor for cardiovascular diseases [5,8,[12][13][14][15][16][17][18]. It's thought that the increase in Hcy levels causes atherosclerosis and thrombosis through several ways [1,10,11,[18][19][20].…”

The Study of Biomarker Homocysteine as Risk Factor in Acute Cerebral Stroke Patients of Western Rajasthan

“…[14] Diets abundant in vegetables, fruits and bread can result in reduction in the PHcy. [15] Elevated levels of Homocysteine (eHcy or hyperhomocysteinaemia) occur with aging and decreased renal function. [14][15][16][17] Our study has observed a strong link between hyperhomocysteinaemia and ischaemic stroke.…”

“…[15] Elevated levels of Homocysteine (eHcy or hyperhomocysteinaemia) occur with aging and decreased renal function. [14][15][16][17] Our study has observed a strong link between hyperhomocysteinaemia and ischaemic stroke. The findings are supported by recent study, which showed that hyperhomocysteinaemia was found in 48% of ischaemic stroke patients.…”